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1. Full Text Pasireotide is more effective than octreotide in reducing hepatorenal cystogenesis in rodents with polycystic kidney and liver diseases
by Masyuk, Tatyana V and Radtke, Brynn N and Stroope, Angela J and Banales, Jesús M and Gradilone, Sergio A and Huang, Bing and Masyuk, Anatoliy I and Hogan, Marie C and Torres, Vicente E and LaRusso, Nicholas F
Hepatology, ISSN 0270-9139, 07/2013, Volume 58, Issue 1, pp. 409 - 421
In polycystic liver (PLD) and kidney (PKD) diseases, increased cyclic adenosine monophosphate (cAMP) levels trigger hepatorenal cystogenesis. A reduction of... 
SOM230 | INTERNALIZATION | INHIBITION | SOMATOSTATIN RECEPTOR SUBTYPES | ANALOGS | GROWTH | LONG-ACTING SOMATOSTATIN | PROLIFERATION | GASTROENTEROLOGY & HEPATOLOGY | EXPRESSION | Cysts - drug therapy | Somatostatin - analogs & derivatives | Humans | Rats | Polycystic Kidney Diseases - drug therapy | Octreotide - therapeutic use | Octreotide - metabolism | Receptors, Somatostatin - biosynthesis | Animals | Receptors, Somatostatin - drug effects | Liver Diseases - drug therapy | Mice | Receptors, Somatostatin - metabolism | Somatostatin - therapeutic use | Cell Cycle - drug effects | Cyclic AMP - metabolism | Somatostatin - metabolism | Polycystic Kidney, Autosomal Dominant - drug therapy | Cysts | Vascular endothelial growth factor | Liver | Hepatology
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2. Somatostatin
by Srikant, Coimbatore B
2004, Endocrine updates, ISBN 9781402077999, Volume 24, xvi, 311
Gene Targeting | genetics | analogs & derivatives | Receptors, Somatostatin | Somatostatin | therapeutic use | Evolution, Molecular
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3. Full Text Somatostatin receptors: From signaling to clinical practice
by Theodoropoulou, Marily and Stalla, Günter K
Frontiers in Neuroendocrinology, ISSN 0091-3022, 2013, Volume 34, Issue 3, pp. 228 - 252
Highlights • Somatostatin is a wide-range antisecretory peptide that binds to five receptors (SSTR1–5). • SSTR1, 2, 3 and 5 exert their antiproliferative... 
Endocrinology & Metabolism | Signal transduction | Pituitary | mTOR | Octreotide | Dopastatin | Somatostatin | Proliferation | Pasireotide | Neuroendocrine tumor | Somatostatin receptors | MTOR | ENDOCRINE GASTROENTEROPANCREATIC TUMORS | THYROID-STIMULATING HORMONE | CELL-CYCLE ARREST | SECRETING PITUITARY-ADENOMAS | NEUROSCIENCES | ADVANCED NEUROENDOCRINE TUMORS | LANREOTIDE LANREOTIDE AUTOGEL | GROWTH-HORMONE-RELEASE | ANALOG SMS 201-995 | ENDOCRINOLOGY & METABOLISM | LONG-TERM TREATMENT | PROTEIN-TYROSINE-PHOSPHATASE | Dopamine - therapeutic use | Carcinoma, Neuroendocrine - diagnosis | Somatostatin - analogs & derivatives | Somatostatin - adverse effects | Carcinoma, Neuroendocrine - drug therapy | Humans | Octreotide - therapeutic use | TOR Serine-Threonine Kinases - antagonists & inhibitors | Animals | Dopamine - analogs & derivatives | Signal Transduction - drug effects | Receptors, Somatostatin - drug effects | Peptides, Cyclic - therapeutic use | Receptors, Somatostatin - physiology | Cell Proliferation - drug effects | Somatostatin - therapeutic use | Radiopharmaceuticals
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4. Full Text Pasireotide and octreotide antiproliferative effects and sst2 trafficking in human pancreatic neuroendocrine tumor cultures
by Mohamed, Amira and Blanchard, Marie-Pierre and Albertelli, Manuela and Barbieri, Federica and Brue, Thierry and Niccoli, Patricia and Delpero, Jean-Robert and Monges, Genevieve and Garcia, Stephane and Ferone, Diego and Florio, Tullio and Enjalbert, Alain and Moutardier, Vincent and Schonbrunn, Agnes and Gerard, Corinne and Barlier, Anne and Saveanu, Alexandru
Endocrine-Related Cancer, ISSN 1351-0088, 10/2014, Volume 21, Issue 5, pp. 691 - 704
Gastroenteropancreatic neuroendocrine tumors (GEP-NETs) raise difficult therapeutic problems despite the emergence of targeted therapies. Somatostatin analogs... 
Primary culture | Octreotide | Human pancreatic neuroendocrine tumors | Pasireotide | Receptor trafficking | Somatostatin receptors | Caspase 7 - metabolism | Cell Survival - drug effects | Somatostatin - analogs & derivatives | Pancreatic Neoplasms - metabolism | Antineoplastic Agents, Hormonal - pharmacology | Apoptosis - drug effects | Neuroendocrine Tumors - metabolism | Humans | Intestinal Neoplasms - metabolism | Middle Aged | Caspase 3 - metabolism | Stomach Neoplasms - metabolism | Male | Octreotide - pharmacology | Somatostatin - pharmacology | Chromogranin A - secretion | DNA Fragmentation | Adult | Female | Aged | Cell Proliferation - drug effects | Receptors, Somatostatin - metabolism | Tumor Cells, Cultured | Cyclic AMP - metabolism | Neuroendocrine Tumors | Cell Proliferation | Life Sciences | Caspase 3 | Receptors, Somatostatin | Biomolecules | Somatostatin | Caspase 7 | Pancreatic Neoplasms | Stomach Neoplasms | Antineoplastic Agents, Hormonal | Chromogranin A | Cell Survival | Biochemistry, Molecular Biology | Cyclic AMP | Intestinal Neoplasms | Apoptosis
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5. Full Text Radiolabeled Somatostatin Receptor Antagonists Are Preferable to Agonists for in Vivo Peptide Receptor Targeting of Tumors
by Mihaela Ginj and Hanwen Zhang and Beatrice Waser and Renzo Cescato and Damian Wild and Xuejuan Wang and Judit Erchegyi and Jean Rivier and Helmut R. Mäcke and Jean Claude Reubi
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 10/2006, Volume 103, Issue 44, pp. 16436 - 16441
Targeting neuroendocrine tumors expressing somatostatin receptor subtypes (sst) with radiolabeled somatostatin agonists is an established diagnostic and... 
Receptors | HEK293 cells | Peptide receptors | Internalization | Fluorescent antibody techniques | Agonists | Antagonists | Radioactive decay | Somatostatin receptors | Tumors | Receptor internalization | Neuropeptides | Antagonist radioligands | Peptide hormones | Tumor targeting | SUBTYPE | OCTREOTIDE | tumor targeting | ANALOGS | MULTIDISCIPLINARY SCIENCES | SCINTIGRAPHY | HIGH-AFFINITY | neuropeptides | ENDOCYTOSIS | antagonist radioligands | INTERNALIZATION | peptide hormones | THERAPY | receptor internalization | RADIOTHERAPY | AUTORADIOGRAPHY | Neoplasms - metabolism | Somatostatin - analogs & derivatives | Humans | Receptors, Somatostatin - agonists | Animals | Mice, Nude | Receptors, Somatostatin - antagonists & inhibitors | Receptors, Somatostatin - chemistry | Mice | Molecular Structure | Receptors, Somatostatin - metabolism | Radioligand Assay | Neoplasms - pathology | Somatostatin - metabolism | Receptors, Peptide - metabolism | Biological Sciences
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6. Full Text Antitumor effects of somatostatin
by Pyronnet, Stéphane and Bousquet, Corinne and Najib, Souad and Azar, Rania and Laklai, Hanane and Susini, Christiane
Molecular and Cellular Endocrinology, ISSN 0303-7207, 2008, Volume 286, Issue 1, pp. 230 - 237
Since its discovery three decades ago as an inhibitor of GH release from the pituitary gland, somatostatin has attracted much attention because of its... 
Analogs | Signaling | Tumor | Somatostatin | Proliferation | Receptor | signaling | ACTIVATED PROTEIN-KINASE | NEUROENDOCRINE TUMORS | proliferation | NITRIC-OXIDE SYNTHASE | SST2 SOMATOSTATIN | PHOSPHOTYROSINE-PHOSPHATASE-ETA | RECEPTOR GENE-EXPRESSION | CELL BIOLOGY | receptor | TUMOR SHRINKAGE | tumor | somatostatin | ENDOCRINOLOGY & METABOLISM | analogs | NONFUNCTIONING PITUITARY-ADENOMAS | ENDOTHELIAL GROWTH-FACTOR | PANCREATIC-CANCER CELLS | Neoplasms - metabolism | Somatostatin - analogs & derivatives | Antineoplastic Agents, Hormonal - pharmacology | Apoptosis - drug effects | Humans | Somatostatin - pharmacology | Neoplasms - drug therapy | Receptors, Somatostatin - agonists | Animals | Human Growth Hormone - metabolism | Signal Transduction - drug effects | Antineoplastic Agents, Hormonal - therapeutic use | Cell Proliferation - drug effects | Receptors, Somatostatin - metabolism | Somatostatin - therapeutic use | Cell Cycle - drug effects | Physiological aspects | Analysis | Tumors
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7. Full Text Diabetes recovery by age-dependent conversion of pancreatic δ-cells into insulin producers
by Chera, Simona and Baronnier, Delphine and Ghila, Luiza and Cigliola, Valentina and Jensen, Jan N and Gu, Guoqiang and Furuyama, Kenichiro and Thorel, Fabrizio and Gribble, Fiona M and Reimann, Frank and Herrera, Pedro L
Nature, ISSN 0028-0836, 10/2014, Volume 514, Issue 7253, pp. 503 - 507
Total or near-total loss of insulin-producing beta-cells occurs in type 1 diabetes(1,2). Restoration of insulin production in type 1 diabetes is thus a major... 
ALPHA | ABLATION | PROLIFERATION | DB/DB MICE | MULTIDISCIPLINARY SCIENCES | BETA-CELLS | Cell Proliferation | Humans | Somatostatin-Secreting Cells - cytology | Cell Dedifferentiation | Diabetes Mellitus, Type 1 - therapy | Insulin - biosynthesis | Diabetes Mellitus, Experimental - therapy | Insulin-Secreting Cells - metabolism | Forkhead Transcription Factors - metabolism | Glucagon-Secreting Cells - metabolism | Cell Transdifferentiation | Insulin-Secreting Cells - cytology | Insulin Secretion | Somatostatin - metabolism | Sexual Maturation | Glucagon-Secreting Cells - cytology | Diabetes Mellitus, Type 1 - pathology | Somatostatin - biosynthesis | Regeneration | Insulin - metabolism | Animals | Aging - physiology | Diabetes Mellitus, Experimental - pathology | Forkhead Box Protein O1 | Mice | Somatostatin-Secreting Cells - metabolism | Index Medicus
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8. Full Text Somatostatin and Its Receptor Family
by Patel, Yogesh C
Frontiers in Neuroendocrinology, ISSN 0091-3022, 07/1999, Volume 20, Issue 3, pp. 157 - 198
Somatostatin (SST), a regulatory peptide, is produced by neuroendocrine, inflammatory, and immune cells in response to ions, nutrients, neuropeptides,... 
expression | secretion | receptors | cell proliferation | signal transduction | somatostatin | Cell proliferation | Signal transduction | Receptors | Somatostatin | Expression | Secretion | SUBTYPE-2 KNOCKOUT MICE | GONADOTROPIN-RELEASING-HORMONE | CENTRAL NERVOUS-SYSTEM | PHOSPHOTYROSINE PHOSPHATASE-ACTIVITY | NEUROSCIENCES | GH4C1 PITUITARY-CELLS | BREAST-CANCER CELLS | MESSENGER-RIBONUCLEIC-ACID | ENDOCRINOLOGY & METABOLISM | ACTIVATED CALCIUM CHANNELS | 5'-FLANKING PROMOTER REGION | PROTEIN-TYROSINE-PHOSPHATASE | Amino Acid Sequence | Somatostatin - agonists | Somatostatin - genetics | Signal Transduction | Receptors, Somatostatin - immunology | Humans | Gene Expression Regulation | Molecular Sequence Data | Somatostatin - antagonists & inhibitors | Receptors, Somatostatin - genetics | Animals | Cell Division | Receptors, Somatostatin - chemistry | Receptors, Somatostatin - metabolism | Somatostatin - metabolism | GTP-Binding Proteins - metabolism | Neuropeptides | Cellular signal transduction | Glutamate | Tumor proteins
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