X
Search Filters
Format Format
Format Format
X
Sort by Item Count (A-Z)
Filter by Count
Journal Article (7053) 7053
Newsletter (1995) 1995
Publication (1030) 1030
Book Review (90) 90
Book Chapter (76) 76
Conference Proceeding (26) 26
Newspaper Article (18) 18
Dissertation (16) 16
Government Document (11) 11
Book / eBook (3) 3
Transcript (2) 2
Data Set (1) 1
Magazine Article (1) 1
Reference (1) 1
Web Resource (1) 1
more...
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
sphingosine (4404) 4404
animals (3323) 3323
humans (3093) 3093
sphingosine - analogs & derivatives (2904) 2904
index medicus (2744) 2744
sphingosine 1-phosphate (1984) 1984
biochemistry & molecular biology (1940) 1940
sphingosine - pharmacology (1898) 1898
research (1865) 1865
sphingosine-1-phosphate (1674) 1674
mice (1546) 1546
phosphates (1485) 1485
sphingosine - metabolism (1373) 1373
cell biology (1357) 1357
apoptosis (1259) 1259
signal transduction (1179) 1179
sphingosine kinase (1118) 1118
lipids (1020) 1020
cancer (978) 978
activation (975) 975
sphingolipids (936) 936
lysophospholipids - metabolism (931) 931
cells, cultured (930) 930
ceramide (904) 904
phosphorylation (874) 874
male (867) 867
phosphotransferases - metabolism (851) 851
rats (814) 814
reports (810) 810
physiological aspects (727) 727
universities and colleges (671) 671
cells (669) 669
female (638) 638
kinases (621) 621
article (595) 595
analysis (592) 592
protein-kinase-c (590) 590
cell line (587) 587
expression (587) 587
phosphotransferases (564) 564
inflammation (553) 553
enzyme inhibitors - pharmacology (544) 544
pharmacology & pharmacy (523) 523
signal transduction - drug effects (523) 523
oncology (521) 521
proteins (507) 507
receptors, lysosphingolipid - metabolism (504) 504
enzymes (494) 494
inhibition (481) 481
lysophospholipids - pharmacology (481) 481
apoptosis - drug effects (472) 472
biophysics (472) 472
cell line, tumor (445) 445
1-phosphate (437) 437
fty720 (418) 418
lysophosphatidic acid (407) 407
lysophospholipids (407) 407
phosphotransferases - genetics (406) 406
kinase (398) 398
health aspects (397) 397
gene expression (396) 396
sphingosine kinase 1 (391) 391
immunology (390) 390
biochemistry (389) 389
mice, inbred c57bl (366) 366
research article (363) 363
calcium - metabolism (362) 362
phosphotransferases - antagonists & inhibitors (360) 360
protein kinase c - metabolism (360) 360
physiology (359) 359
neurosciences (357) 357
sphingolipids - metabolism (355) 355
metabolism (352) 352
dose-response relationship, drug (349) 349
proliferation (348) 348
protein kinase c - antagonists & inhibitors (347) 347
signal transduction - physiology (345) 345
enzyme activation (334) 334
receptor (333) 333
protein-coupled receptor (328) 328
ceramides - metabolism (325) 325
multidisciplinary sciences (325) 325
endothelial-cells (319) 319
kinetics (314) 314
molecular-cloning (314) 314
receptors (314) 314
signal-transduction (308) 308
development and progression (306) 306
biology (303) 303
care and treatment (302) 302
growth (302) 302
tetradecanoylphorbol acetate - pharmacology (299) 299
fingolimod hydrochloride (298) 298
enzyme activation - drug effects (297) 297
angiogenesis (288) 288
sphingosine - physiology (286) 286
time factors (285) 285
protein kinases (278) 278
in-vivo (277) 277
endothelium (273) 273
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (9074) 9074
Japanese (26) 26
Chinese (16) 16
Russian (10) 10
Korean (8) 8
French (3) 3
German (3) 3
Spanish (2) 2
Turkish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Biochemical Journal, ISSN 0264-6021, 07/2009, Volume 421, Issue 1, pp. 29 - 42
mTOR (mammalian target of rapamycin) stimulates cell growth by phosphorylating and promoting activation of AGC (protein kinase A/protein kinase G/protein... 
Phosphoinositide 3-kinase (PI3K) | Akt/protein kinase B (PKB) | Serum and glucocorticoid protein kinase (SGK) | P70 ribosomal S6 kinase (S6K) | Kinase inhibitor | Cancer | IN-VIVO ROLE | PROTEIN-KINASE B/AKT | BINDING PARTNER | RAG GTPASES | BIOCHEMISTRY & MOLECULAR BIOLOGY | IDENTIFICATION | P70 S6 KINASE | kinase inhibitor | phosphoinositide 3-kinase (PI3K) | p70 ribosomal S6 kinase (S6K) | SUBSTRATE-SPECIFICITY | HYDROPHOBIC MOTIF PHOSPHORYLATION | cancer | serum and glucocorticoid protein kinase (SGK) | COMPLEX 2 | PDK1 | Cell Line | Humans | Multiprotein Complexes | Morpholines - pharmacology | Transcription Factors - antagonists & inhibitors | Gene Expression Profiling | G1 Phase - drug effects | Pyrimidines - pharmacology | Morpholines - chemistry | Pyrimidines - chemistry | Mechanistic Target of Rapamycin Complex 1 | Gene Expression Regulation - drug effects | Proteins | Transcription Factors - metabolism | Animals | Fibroblasts - drug effects | Cell Proliferation - drug effects | Mice | TOR Serine-Threonine Kinases | Fibroblasts - metabolism | PI3K, phosphoinositide 3-kinase | PDK, 3-phosphoinositide-dependent protein kinase | AMPK, AMP-activated protein kinase | mTORC, mTOR complex | DTT, dithiothreitol | SPHK, sphingosine kinase | ERK, extracellular-signal-regulated kinase | RSK, ribosomal S6 kinase | PH domain, pleckstrin homology domain | protein kinase B (PKB) | protein kinase G | NDRG1, N-Myc downstream-regulated gene-1 | IGF, insulin-like growth factor | mTOR, mammalian target of rapamycin | GST, glutathione transferase | SGK, serum and glucocorticoid protein kinase | PKC, protein kinase C | S6K, p70 ribosomal S6 kinase | eIF4E, eukaryotic initiation factor 4E | 4E-BP1, eIF4E-binding protein 1 | protein kinase C family | Akt | PRAS40, proline-rich Akt substrate of 40 kDa | HEK-293 cell, human embryonic kidney 293 cell | MEF, mouse embryonic fibroblast | AGC family, protein kinase A | MAPK, mitogen-activated protein kinase
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2014, Volume 9, Issue 9, p. e106725
Successful placentation depends on the proper invasion of extravillous trophoblast (EVT) cells into maternal tissues. Previous reports demonstrated that S1P... 
MIGRATION | APOPTOSIS | CANCER CELLS | PROTEIN-COUPLED RECEPTOR | EARLY HUMAN-PREGNANCY | MULTIDISCIPLINARY SCIENCES | PROLIFERATION | HUMAN DECIDUA | EXPRESSION | SPHINGOSINE 1-PHOSPHATE | RHO/RHO-KINASE | RNA, Small Interfering - genetics | Humans | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Collagen - chemistry | Proteoglycans - chemistry | MAP Kinase Kinase 1 - genetics | Trophoblasts - drug effects | Mitogen-Activated Protein Kinase 1 - genetics | Lysophospholipids - pharmacology | Receptors, Lysosphingolipid - genetics | Biological Assay | Trophoblasts - cytology | Receptors, Lysosphingolipid - metabolism | MAP Kinase Kinase 2 - genetics | Cell Line | MAP Kinase Kinase 1 - antagonists & inhibitors | Trophoblasts - metabolism | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Matrix Metalloproteinase 2 - metabolism | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | Gene Expression Regulation | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Sphingosine - pharmacology | Cell Movement - drug effects | Matrix Metalloproteinase 2 - genetics | Sphingosine - analogs & derivatives | Diffusion Chambers, Culture | Mitogen-Activated Protein Kinase 3 - metabolism | MAP Kinase Kinase 2 - antagonists & inhibitors | Receptors, Lysosphingolipid - agonists | Laminin - chemistry | Protein Kinase Inhibitors - pharmacology | Drug Combinations | Mitogen-Activated Protein Kinase 1 - metabolism | RNA, Small Interfering - metabolism | Phosphates | Enzymes | RNA | Sphingosine | Enzyme activity | Extracellular signal-regulated kinase | Activation | mRNA | siRNA | Kinases | Gene expression | Tissues | Sphingosine 1-phosphate | Cell adhesion & migration | Gelatinase A | Pregnancy | Proteins | Signaling | Receptors | Molecular modelling | Pathways | Enzymatic activity | Gelatin | Pharmacy | Receptor mechanisms | Cell migration | Cancer
Journal Article
Journal Article
STEM CELLS, ISSN 1066-5099, 11/2006, Volume 24, Issue 11, pp. 2557 - 2565
The ease of isolation and ex vivo culture of marrow‐derived stromal cells (MSCs) from adult bone marrow renders them a very promising source of adult stem... 
Matrix metalloproteinases | Rho GTPases | Marrow‐derived stromal cells | ROCK MEK1/ERK | Actin cytoskeleton | Cell migration | Sphingosine‐1‐phosphate | MEK1/ERK | ROCK | Marrow-derived stromal cells | Sphingosine-1-phosphate | GLIOMA-CELLS | PAXILLIN | marrow-derived stromal cells | BONE-MARROW | CANCER | MESENCHYMAL STEM-CELLS | SPHINGOSINE 1-PHOSPHATE | CELL & TISSUE ENGINEERING | CELL BIOLOGY | actin cytoskeleton | ONCOLOGY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | cell migration | sphingosine-1-phosphate | FOCAL ADHESION KINASE | GROWTH-FACTOR | RHO-GTPASES | HEMATOLOGY | matrix metalloproteinases | MOTILITY | Paxillin - metabolism | Phosphorylation | Bone Marrow Cells - enzymology | rhoA GTP-Binding Protein - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Dose-Response Relationship, Drug | Stromal Cells - enzymology | Actin Cytoskeleton - drug effects | rho-Associated Kinases | Lysophospholipids - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Bone Marrow Cells - drug effects | Female | Indoles - pharmacology | Flavonoids - pharmacology | Protein-Serine-Threonine Kinases - metabolism | Amides - pharmacology | MAP Kinase Kinase 1 - antagonists & inhibitors | Actin Cytoskeleton - metabolism | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Stromal Cells - metabolism | Cells, Cultured | Enzyme Inhibitors - pharmacology | MAP Kinase Kinase 1 - metabolism | Chemotaxis - drug effects | Hydroxamic Acids | Cell Shape - drug effects | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | MAP Kinase Signaling System - drug effects | Matrix Metalloproteinase Inhibitors | Mice | Pyridines - pharmacology | Matrix Metalloproteinases - metabolism | Bone Marrow Cells - metabolism
Journal Article
Journal Article
Journal Article
Circulation Research: Journal of The American Heart Association, ISSN 0009-7330, 07/2002, Volume 91, Issue 2, pp. 112 - 119
Although recent investigations have suggested that a Rho-kinase–mediated Ca sensitization of vascular smooth muscle contraction plays a critical role in the... 
Rho-kinase | Sphingolipid | Membrane permeabilization | Vasospasm | Protein kinase C | SIGNALING PATHWAYS | CARDIAC & CARDIOVASCULAR SYSTEMS | SKINNED MUSCLE | sphingolipid | PERMEABILIZED SMOOTH-MUSCLE | PHOSPHORYLATION | vasospasm | membrane permeabilization | ARACHIDONIC-ACID | ENDOTHELIAL-CELLS | SUBARACHNOID HEMORRHAGE | PERIPHERAL VASCULAR DISEASE | CHRONIC VASOSPASM | HEMATOLOGY | MYOSIN LIGHT-CHAIN | protein kinase C | CALCIUM SENSITIZATION | Protein-Serine-Threonine Kinases - analysis | Culture Techniques | Phorbol 12,13-Dibutyrate - pharmacology | Phosphorylcholine - analogs & derivatives | Cerebral Arteries - drug effects | Cattle | Phosphorylcholine - pharmacology | rho-Associated Kinases | Escin - pharmacology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Calcium Signaling | Muscle, Smooth, Vascular - physiology | Muscle, Smooth, Vascular - drug effects | GTP-Binding Proteins - physiology | Protein Kinase C - physiology | Protein-Serine-Threonine Kinases - physiology | Cells, Cultured | Enzyme Inhibitors - pharmacology | Intracellular Signaling Peptides and Proteins | Protein Kinase C - antagonists & inhibitors | Cerebral Arteries - physiology | Sphingosine - pharmacology | Cell Membrane - enzymology | Sphingosine - analogs & derivatives | Animals | Cerebral Arteries - enzymology | Cerebral Arteries - metabolism | Muscle Contraction - drug effects | Cell Membrane Permeability - drug effects | Kinetics
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 12/2004, Volume 91, Issue 5, pp. 1231 - 1243
The sphingomyelin‐derived messenger ceramides provoke neuronal apoptosis through caspase‐3 activation, while the neuropeptide pituitary adenylate... 
Bax | Bcl‐2 | pituitary adenylate cyclase‐activating polypeptide | mitochondrial apoptotic pathway | JNK | ERK | Bcl-2 | Pituitary adenylate cyclase-activating polypeptide | Mitochondrial apoptotic pathway | NEURONAL APOPTOSIS | CYCLASE-ACTIVATING POLYPEPTIDE | SIGNALING PATHWAYS | pituitary adenylate cyclase-activating polypeptide | BIOCHEMISTRY & MOLECULAR BIOLOGY | DEATH | CERAMIDE LEVELS | NEUROSCIENCES | CYTOCHROME-C | CASPASE-3 ACTIVATION | PITUITARY | ADENYLATE-CYCLASE | CEREBRAL-ISCHEMIA | Intracellular Signaling Peptides and Proteins - pharmacology | Benzimidazoles | Caspase 9 | Rats, Wistar | Cytosol - drug effects | JNK Mitogen-Activated Protein Kinases - metabolism | Intracellular Signaling Peptides and Proteins - metabolism | Carbocyanines | Dose-Response Relationship, Drug | Nerve Growth Factors - pharmacology | Mitogen-Activated Protein Kinase Kinases - metabolism | Proto-Oncogene Proteins c-bcl-2 - metabolism | RNA, Messenger - biosynthesis | Caspases - metabolism | Drug Interactions | MAP Kinase Kinase 4 | Time Factors | Neuropeptides - pharmacology | Neurotransmitter Agents - pharmacology | Reverse Transcriptase Polymerase Chain Reaction - methods | Caspase 3 | Neurons - drug effects | Pituitary Adenylate Cyclase-Activating Polypeptide | Animals, Newborn | Membrane Potentials - drug effects | Blotting, Western - methods | Cytochromes c - metabolism | Fluorescent Antibody Technique - methods | Cells, Cultured | Enzyme Inhibitors - pharmacology | Rats | Mitochondria - drug effects | bcl-2-Associated X Protein | Gene Expression Regulation - drug effects | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Signal Transduction - drug effects | Cerebellum - cytology | Mice | Models, Neurological | Mitochondria - physiology | Proto-Oncogene Proteins c-bcl-2 - genetics | Mitogen-Activated Protein Kinases - metabolism | Cerebellum | Enzyme Inhibitors | Cytochromes c | Neuropeptides | Cytosol | Life Sciences | Mitochondria | Toxicology | Mitogen-Activated Protein Kinase Kinases | Sphingosine | JNK Mitogen-Activated Protein Kinases | Mitogen-Activated Protein Kinases | Signal Transduction | Neurons | Gene Expression Regulation | Intracellular Signaling Peptides and Proteins | Reverse Transcriptase Polymerase Chain Reaction | Blotting, Western | Neurotransmitter Agents | Membrane Potentials | Nerve Growth Factors | Fluorescent Antibody Technique | Proto-Oncogene Proteins c-bcl-2 | Caspases | RNA, Messenger
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 05/2011, Volume 286, Issue 21, pp. 18633 - 18640
Journal Article