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Science, ISSN 0036-8075, 5/2009, Volume 324, Issue 5928, pp. 801 - 804
New drugs are required to counter the tuberculosis (TB) pandemic. Here, we describe the synthesis and characterization of 1,3-benzothiazin-4-ones (BTZs), a new... 
Enzymes | Antibacterials | Tuberculosis | Mycobacterium tuberculosis | Cell walls | Antituberculars | Bacteria | Reports | Biochemistry | Enantiomers | Codons | IDENTIFICATION | MULTIDISCIPLINARY SCIENCES | CELL-WALL | Antitubercular Agents - chemical synthesis | Antitubercular Agents - chemistry | Thiazines - therapeutic use | Ethambutol - pharmacology | Drug Resistance, Bacterial | Molecular Sequence Data | Spiro Compounds - therapeutic use | Tuberculosis - microbiology | Mycobacterium tuberculosis - drug effects | Polysaccharides - biosynthesis | Microbial Sensitivity Tests | Racemases and Epimerases - metabolism | Enzyme Inhibitors - chemistry | Spiro Compounds - chemical synthesis | Tuberculosis - drug therapy | Arabinose - metabolism | Thiazines - pharmacology | Molecular Structure | Mycobacterium tuberculosis - metabolism | Spiro Compounds - chemistry | Antitubercular Agents - therapeutic use | Amino Acid Sequence | Genes, Bacterial | Antitubercular Agents - pharmacology | Enzyme Inhibitors - pharmacology | Racemases and Epimerases - antagonists & inhibitors | Enzyme Inhibitors - therapeutic use | Thiazines - chemical synthesis | Thiazines - chemistry | Mycobacterium - genetics | Mycobacterium - drug effects | Gene Expression Regulation, Bacterial - drug effects | Animals | Cell Wall - metabolism | Enzyme Inhibitors - cerebrospinal fluid | Mice | Mice, Inbred BALB C | Spiro Compounds - pharmacology | Mycobacterium tuberculosis - genetics | Antitubercular agents | Dosage and administration | Drug therapy | Genetics | Pharmacology | Chemical synthesis
Journal Article
Clinical Infectious Diseases, ISSN 1058-4838, 11/2017, Volume 65, Issue 10, pp. 1711 - 1720
Background. Administration of artemisinin-based combination therapy (ACT) to infant and young children can be challenging. A formulation with accurate dose and... 
dispersible tablet | arterolane maleate | P. falciparum | pediatric | INFECTIOUS DISEASES | ADULTS | MICROBIOLOGY | IMMUNOLOGY | COMBINATION | ANTIMALARIAL | CHILDREN | PHARMACOKINETICS | DIHYDROARTEMISININ-PIPERAQUINE | ARTESUNATE PLUS AMODIAQUINE | Quinolines - blood | Ethanolamines - adverse effects | Artemisinins - pharmacokinetics | Tablets | Humans | Fluorenes - therapeutic use | Antimalarials - blood | Child, Preschool | Infant | Male | Spiro Compounds - therapeutic use | Peroxides - therapeutic use | Spiro Compounds - adverse effects | Peroxides - pharmacokinetics | Peroxides - adverse effects | Quinolines - pharmacokinetics | Ethanolamines - pharmacokinetics | Malaria, Falciparum - mortality | Artemisinins - blood | Female | Fluorenes - adverse effects | Fluorenes - blood | Child | Antimalarials - adverse effects | Fluorenes - pharmacokinetics | Malaria, Falciparum - drug therapy | Antimalarials - pharmacokinetics | Heterocyclic Compounds, 1-Ring - pharmacokinetics | Africa | Antimalarials - therapeutic use | Spiro Compounds - pharmacokinetics | India | Ethanolamines - blood | Peroxides - blood | Artemisinins - therapeutic use | Spiro Compounds - blood | Heterocyclic Compounds, 1-Ring - adverse effects | Survival Analysis | Heterocyclic Compounds, 1-Ring - therapeutic use | Ethanolamines - therapeutic use | Quinolines - therapeutic use | Heterocyclic Compounds, 1-Ring - blood | Artemisinins - adverse effects | Drug Combinations | Quinolines - adverse effects
Journal Article
Journal of Medicinal Chemistry, ISSN 0022-2623, 12/2009, Volume 52, Issue 24, pp. 7970 - 7973
Journal Article
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 09/2012, Volume 77, Issue 17, pp. 7187 - 7211
Journal Article
Journal Article