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spirocycles (169) 169
chemistry, organic (121) 121
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Chemistry – A European Journal, ISSN 0947-6539, 04/2018, Volume 24, Issue 21, pp. 5398 - 5398
A new spirocyclic amino acid for drug discovery, a surrogate for l‐proline/pipecolic acids, is described. The synthesis of multifunctional spirocycles starts... 
bioisosterism | piperidine | drug discovery | azetidine | spirocycles
Journal Article
Angewandte Chemie - International Edition, ISSN 1433-7851, 02/2019, Volume 58, Issue 8, pp. 2474 - 2478
The enantioselective synthesis of a series of C -symmetric 3,3'-diarylated 1,1'-spirobiindane-7,7'-diols (3,3'-diaryl-SPINOLs) was developed by sequential... 
ligand design | asymmetric synthesis | conjugate addition | spirocycles | rhodium
Journal Article
Angewandte Chemie International Edition, ISSN 1433-7851, 11/2016, Volume 55, Issue 46, pp. 14389 - 14393
A palladium‐catalyzed cascade reaction based on the trapping of transient alkyl–PdII intermediates with arynes encompassing a C−H activation step has been... 
cascade reactions | aryne | C−H activation | carbopalladation | spirocycles
Journal Article
Tetrahedron Letters, ISSN 0040-4039, 11/2018, Volume 59, Issue 46, pp. 4080 - 4085
Here, we report a simple and useful strategy for a series of C -symmetric π-conjugated and highly soluble spiro-annulated truxene derivatives. The role of... 
Suzuki coupling | Truxenes | Spirocycles | Cyclotrimerization | Ring-closing metathesis
Journal Article
ChemCatChem, ISSN 1867-3880, 04/2017, Volume 9, Issue 7, pp. 1149 - 1156
The transition‐metal‐directed C−H activation processes have traditionally required the installation of suitable coordinating groups to place the metal in close... 
catalysis | palladium | C−H activation | remote | cascade | spirocycles
Journal Article
Advanced Synthesis & Catalysis, ISSN 1615-4150, 02/2019, Volume 361, Issue 3, pp. 562 - 568
A copper‐catalysed double O‐aylation for enantioselective formation of chiral oxa‐spirocycles is described. The method is based on a stepwise process and... 
oxa-Spirocycles | Asymmetric Synthesis | Copper-Catalysed | Chiral Spirocycles | O-Arylation | ASYMMETRIC-SYNTHESIS | NATURAL-PRODUCTS | ORGANOCATALYTIC STRATEGY | CHEMISTRY, ORGANIC | BOND FORMATION | DISCOVERY | DESYMMETRIZATION | SPIROOXINDOLES | CONSTRUCTION | INHIBITORS | CHEMISTRY, APPLIED | DEAROMATIZATION | Copper | Enantiomers | Chemical synthesis
Journal Article
Synlett, ISSN 0936-5214, 01/2017, Volume 28, Issue 2, pp. 231 - 234
Abstract A series of novel N -Bn-protected spirocyclic β-proline esters were prepared using [3+2] cycloaddition and subsequently converted into their... 
letter | oxetanes | intramolecular cyclization | spirocycles | β-proline esters | 1,3-dipolar cycloaddition
Journal Article
Synlett, ISSN 0936-5214, 12/2017, Volume 28, Issue 20, pp. 2933 - 2935
Abstract Exocyclic, conjugated enals react with benzynes generated by heating various triyne-containing substrates to produce spirocyclic benzopyran... 
letter | arynes | cascades | electrocyclizations | spirocycles | benzoxetenes | CHEMISTRY | CHEMISTRY, ORGANIC | ALDEHYDES
Journal Article
Synlett, ISSN 0936-5214, 05/2017, Volume 28, Issue 8, pp. 934 - 938
Abstract Spiropseudoindoxyls were synthesized by using a gold(III)-catalyzed intramolecular nitroalkyne redox–dipolar cycloaddition cascade. These compounds... 
letter | dihydro-γ-carbolinone | indoles | Wagner-Meerwein | 1,2-acyl shift | spirocycles
Journal Article
Synthesis, ISSN 0039-7881, 11/2016, Volume 48, Issue 21, pp. 3803 - 3811
Abstract In this study, a one-pot, three-component reaction of two molecules of indane-1,3-dione with aromatic aldehydes for the synthesis of... 
paper | Michael addition | cyclopropane | indane-1,3-dione | N-halosulfonamides | spirocycles | ring closure
Journal Article
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, ISSN 1433-7851, 11/2016, Volume 55, Issue 46, pp. 14387 - 14391
A palladium-catalyzed cascade reaction based on the trapping of transient alkyl-Pd-II intermediates with arynes encompassing a C-H activation step has been... 
spirocycles | EFFICIENT SYNTHESIS | carbopalladation | ANION CAPTURE PROCESSES | CHEMISTRY, MULTIDISCIPLINARY | HYDRIDE ION CAPTURE | cascade reactions | QUEUING CASCADES | C(SP)-H BOND ACTIVATION | aryne | C-H activation | PRODUCT TOTAL-SYNTHESIS | CARBON-CARBON | HECK REACTION | ALKYL-PALLADIUM | CYCLIZATION
Journal Article
Molecules, ISSN 1420-3049, 11/2019, Volume 24, Issue 22, p. 4165
Spirocyclic motifs are emerging privileged structures for drug discovery. They are also omnipresent in the natural products domain. However, until today, no... 
natural products | privileged structures | biological activity | spirocycles | chemical diversity
Journal Article
Tetrahedron, ISSN 0040-4020, 11/2019, Volume 75, Issue 47, p. 130637
A collection of novel azaspirocyclic β-arylethylamines was prepared in good yield and excellent diastereoselectivity by an expedient strategy that features... 
Sigma receptors | TMEM97 | Spirocycles | Diversity-oriented synthesis | Aza-Sakurai | ROUTE | PRIVILEGED STRUCTURES | STRATEGY | AMINOMETHANO DESILYLATION | CHEMISTRY, ORGANIC | MODELS | CATALYSTS | ALKALOIDS
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 01/2018, Volume 83, Issue 1, pp. 491 - 498
4,5-Diazaspiro­[2.3]­hexanes are made by dihalocarbene addition across the exocyclic double bond of readily accessible 3-alkylidene-1,2-diazetidines. Using... 
CHEMISTRY, ORGANIC | CYCLOADDITION | SPIROCYCLES | OXETANE | STEREOSELECTIVE-SYNTHESIS | Chemical reactions | Usage | Chemical properties | Ring formation (Chemistry) | Carbenes
Journal Article
Chemistry – A European Journal, ISSN 0947-6539, 11/2017, Volume 23, Issue 66, pp. 16691 - 16691
The cover picture shows novel building blocks for drug discovery—spirocyclic pyrrolidine. The synthesis starts from common four‐, five‐, six‐ and... 
azomethine ylides | building blocks | drug discovery | pyrrolidines | spirocycles | Transformation | Synthesis | Alkenes | Ketones | Pyrrolidine | Antibacterial agents
Journal Article
Organic Letters, ISSN 1523-7060, 03/2018, Volume 20, Issue 5, pp. 1439 - 1443
An efficient Ag­(I)-catalyzed π-acid activation method for the cyclization of cyclic ketimine-tethered ynones is reported. Various nitrogen-containing... 
ROUTE | SPIROCYCLES | ENANTIOSELECTIVE SYNTHESIS | ENAMINONES | QUINOLIZIDINE ALKALOIDS | CHEMISTRY, ORGANIC | TERMINAL ALKYNES | ALKYNE ACTIVATION | DIRECT IMINE ACYLATION | PYRROLIZIDINES | DEAROMATIZATION
Journal Article
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