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Circulation Research, ISSN 0009-7330, 06/2008, Volume 102, Issue 12, pp. 1566 - 1574
A human-specific splicing variant of vascular endothelial growth factor (VEGF) receptor 1 (Flt1) was discovered, producing a soluble receptor (designated... 
Vascular smooth muscle cell | Splicing | Soluble VEGF receptor | Preeclampsia | VEGF | CARDIAC & CARDIOVASCULAR SYSTEMS | PLACENTA | soluble VEGF receptor | preeclampsia | REACTIVE OXYGEN | GENE-EXPRESSION | MALARIA | PERIPHERAL VASCULAR DISEASE | splicing | vascular smooth muscle cell | HYPERTENSION | HEMATOLOGY | Muscle, Smooth, Vascular - metabolism | Humans | Recombinant Fusion Proteins - physiology | Vascular Endothelial Growth Factor Receptor-1 - physiology | Homeostasis | Molecular Sequence Data | Vascular Endothelial Growth Factor A - antagonists & inhibitors | Protein Isoforms - blood | RNA Splicing - physiology | Protein Processing, Post-Translational - drug effects | Protein Isoforms - chemistry | Female | Phosphorylation - drug effects | Myocytes, Smooth Muscle - metabolism | Vascular Endothelial Growth Factor A - pharmacology | Vascular Endothelial Growth Factor Receptor-1 - genetics | Amino Acid Sequence | Trophoblasts - metabolism | Endothelial Cells - metabolism | Cornea - chemistry | Muscle, Smooth, Vascular - cytology | Organ Specificity | Vascular Endothelial Growth Factor Receptor-1 - chemistry | Protein Isoforms - physiology | Placenta - metabolism | Pregnancy | Neovascularization, Physiologic - physiology | Placenta - blood supply | Animals | Pre-Eclampsia - blood | Signal Transduction - physiology | Cells, Cultured - metabolism | Vascular Endothelial Growth Factor Receptor-1 - blood | Sus scrofa | Protein Isoforms - genetics | Index Medicus
Journal Article
Journal Article
Nature Immunology, ISSN 1529-2908, 05/2010, Volume 11, Issue 5, pp. 411 - 418
Sensors of pathogens, such as Toll-like receptors (TLRs), detect microbes to activate transcriptional programs that orchestrate adaptive responses to specific... 
UNFOLDED PROTEIN RESPONSE | PATHWAY | ER STRESS | HOST-DEFENSE | ENDOPLASMIC-RETICULUM STRESS | FRANCISELLA-TULARENSIS INFECTION | IMMUNOLOGY | LIVE VACCINE STRAIN | INFLAMMATORY RESPONSE | NEGATIVE REGULATOR | SYSTEMS BIOLOGY | RNA, Small Interfering - genetics | Endoribonucleases - genetics | Tularemia - metabolism | Toll-Like Receptor 2 - genetics | Membrane Glycoproteins - metabolism | Lipopeptides - pharmacology | Transcriptional Activation - drug effects | NADPH Oxidases - metabolism | Tularemia - genetics | Protein Splicing - genetics | Transcriptional Activation - immunology | X-Box Binding Protein 1 | Protein Splicing - drug effects | NADPH Oxidases - genetics | Stress, Physiological - drug effects | TNF Receptor-Associated Factor 6 - genetics | Transcription Factor CHOP - biosynthesis | Transcription Factors - immunology | Cytokines - genetics | Protein-Serine-Threonine Kinases - metabolism | DNA-Binding Proteins - immunology | Endoribonucleases - metabolism | Macrophages - pathology | Stress, Physiological - genetics | Myeloid Differentiation Factor 88 - genetics | Toll-Like Receptor 4 - genetics | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | Toll-Like Receptor 2 - metabolism | Toll-Like Receptor 4 - metabolism | Mice, Knockout | Macrophages - metabolism | Signal Transduction - drug effects | Tunicamycin - pharmacology | Lipopolysaccharides - pharmacology | Toll-Like Receptor 2 - immunology | Mice | Stress, Physiological - immunology | Endoribonucleases - immunology | Transcription Factor CHOP - genetics | NADPH Oxidases - immunology | DNA-Binding Proteins - metabolism | Signal Transduction - immunology | Macrophages - virology | Mice, Mutant Strains | Tularemia - immunology | Membrane Glycoproteins - immunology | Macrophages - immunology | Cytokines - immunology | Cell Line | Francisella tularensis - immunology | Protein Splicing - immunology | Protein-Serine-Threonine Kinases - genetics | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Immunity, Innate | NADPH Oxidase 2 | Regulatory Factor X Transcription Factors | Mice, Inbred C3H | Membrane Glycoproteins - genetics | Transcription Factors - metabolism | Animals | TNF Receptor-Associated Factor 6 - metabolism | Macrophages - drug effects | Protein-Serine-Threonine Kinases - immunology | Francisella tularensis - pathogenicity | Myeloid Differentiation Factor 88 - metabolism | Cytokines - biosynthesis | Cell receptors | Transcription factors | Immune response | Physiological aspects | Genetic aspects | Research | Health aspects | Francisella tularensis | Index Medicus
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2013, Volume 8, Issue 10, pp. e76133 - e76133
Human insulin-like growth factor 1 Ec (IGF-1Ec), also called mechano growth factor (MGF), is a splice variant of insulin-like growth factor 1 (IGF-1), which... 
CELLS | MECHANICAL OVERLOAD | HORMONE | BONE-GROWTH | GENE | MULTIDISCIPLINARY SCIENCES | MUSCLE FUNCTION | MGF EXPRESSION | E-PEPTIDE ACTIONS | ARTICULAR CHONDROCYTES | MONOCLONAL-ANTIBODIES | Chondrocytes - cytology | Alternative Splicing | Humans | Peptides - genetics | Molecular Sequence Data | Muscle, Skeletal - metabolism | Insulin-Like Growth Factor I - genetics | Muscle, Skeletal - cytology | RNA, Messenger - metabolism | Chondrocytes - drug effects | Cell Nucleus - metabolism | Peptides - metabolism | Growth Plate - cytology | Swine | Growth Plate - drug effects | Chondrocytes - metabolism | Amino Acid Sequence | Gene Expression | RNA, Messenger - genetics | Growth Plate - metabolism | Peptides - pharmacology | Sequence Homology, Amino Acid | Mechanotransduction, Cellular | Sequence Alignment | Animals | Cytosol - metabolism | Cell Proliferation - drug effects | Primary Cell Culture | Insulin-Like Growth Factor I - metabolism | Peptides | Analysis | Cell culture | Alternative splicing | Transplants & implants | Insulin-like growth factor I | Insulin-like growth factors | Tissues | Nuclei | Proteins | Cartilage | Growth plate | Embryology | Cell growth | Aging | Physiology | Muscles | Histology | Anatomy & physiology | Insulin | Medicine | Chondrocytes | Nuclei (cytology) | Mechanical stimuli | Cytoplasm | Cancer | Hypertrophy | Index Medicus
Journal Article
Journal of Orthopaedic Research, ISSN 0736-0266, 2004, Volume 22, Issue 4, pp. 847 - 853
Journal Article
Journal Article
Circulation Research, ISSN 0009-7330, 07/2011, Volume 109, Issue 3, pp. e14 - e26
RATIONALE:Systemic sclerosis (SSc) is characterized by widespread microangiopathy, fibrosis, and autoimmunity. Despite the lack of angiogenesis, the expression... 
antiangiogenic agents | systemic sclerosis | peripheral vascular diseases | vascular endothelial growth factor A | angiogenesis | scleroderma | Phosphorylation - physiology | Gene Expression - drug effects | Humans | Transforming Growth Factor beta1 - metabolism | Culture Media, Conditioned - pharmacology | Ischemia - genetics | Vascular Endothelial Growth Factor A - metabolism | RNA-Binding Proteins | Phosphoproteins - metabolism | Vascular Endothelial Growth Factor A - genetics | Gene Expression - physiology | Scleroderma, Systemic - physiopathology | Dermis - blood supply | Neovascularization, Pathologic - physiopathology | Phosphorylation - drug effects | Nuclear Proteins - genetics | Vascular Endothelial Growth Factor A - pharmacology | Endothelial Cells - physiology | Transforming Growth Factor beta1 - pharmacology | Scleroderma, Systemic - metabolism | Cells, Cultured | Scleroderma, Systemic - genetics | Ischemia - metabolism | Vascular Endothelial Growth Factor Receptor-2 - metabolism | Alternative Splicing - physiology | Nuclear Proteins - metabolism | Transforming Growth Factor beta1 - genetics | Ischemia - physiopathology | Phosphoproteins - genetics | Vascular Endothelial Growth Factor B - pharmacology | Signal Transduction - drug effects | Vascular Endothelial Growth Factor B - metabolism | Endothelial Cells - cytology | Serine-Arginine Splicing Factors | Neovascularization, Pathologic - genetics | Signal Transduction - physiology | Vascular Endothelial Growth Factor B - genetics | Neovascularization, Pathologic - metabolism | Index Medicus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 1768, Volume 289, Issue 19, pp. 13651 - 13660
Background: Many pre-mRNAs are alternatively spliced upon T cell activation, but functional implications remain largely unexplored. Results: Alternative... 
Alternative Splicing | TRAF | VARIANTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | HELPER-CELLS | KINASE | RECEPTOR | MESENCHYMAL TRANSITION | PRE-MESSENGER-RNA | RNA Splicing | PROTEIN-INTERACTION NETWORKS | T Cell | DYNAMICS | REGULATORS | Nuclear Factor B (NFB) | PROGRAM
Journal Article
Nature, ISSN 0028-0836, 08/2012, Volume 488, Issue 7412, pp. 508 - 511
Journal Article