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2017, Methods in molecular biology, ISBN 9781493967629, Volume 1555.
Web Resource
2017, Methods in molecular biology, ISBN 9781493967629, Volume 1555.
Web Resource
Biochemical Journal, ISSN 0264-6021, 01/2005, Volume 385, Issue 2, pp. 399 - 408
We developed a high-throughput HTRF (homogeneous time-resolved fluorescence) assay for Akt kinase activity and screened approx. 270000 compounds for their... 
Allosteric inhibitor | Protein kinase B (PKB) | Inhibitor | Pleckstrin homology domain | Akt | Kinase | PROTEIN-KINASE-B | INDUCED APOPTOSIS | TYROSINE KINASE | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | pleckstrin homology domain | allosteric inhibitor | COWDEN-DISEASE | kinase | inhibitor | STRUCTURAL BASIS | protein kinase B (PKB) | TUMOR-SUPPRESSOR | MOLECULAR-CLONING | CELL-LINE LNCAP | HUMAN CANCER | Phosphoproteins - immunology | Prostatic Neoplasms - chemistry | Humans | Peptides - genetics | Blood Proteins - immunology | Male | Isoenzymes - chemistry | Phosphoproteins - chemistry | Carcinoma - chemistry | Peptides - metabolism | TNF-Related Apoptosis-Inducing Ligand | Blood Proteins - genetics | Adenosine Triphosphate - metabolism | Phosphorylation - drug effects | 3-Phosphoinositide-Dependent Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | Peptides - immunology | Enzyme Inhibitors - pharmacology | Heterocyclic Compounds, 2-Ring - pharmacology | Tumor Necrosis Factor-alpha - pharmacology | Cell Line, Tumor | Prostatic Neoplasms - metabolism | Uterine Cervical Neoplasms - pathology | Quinoxalines - pharmacology | Caspases - metabolism | Uterine Cervical Neoplasms - metabolism | Cloning, Molecular | Protein-Serine-Threonine Kinases - antagonists & inhibitors | Female | Molecular Structure | Carcinoma - pathology | Binding, Competitive | Protein Structure, Tertiary | Proto-Oncogene Proteins - metabolism | Prostatic Neoplasms - pathology | Proto-Oncogene Proteins - antagonists & inhibitors | Peptides - chemistry | Membrane Glycoproteins - pharmacology | Blood Proteins - chemistry | Phosphoproteins - genetics | Enzyme Activation - drug effects | Proto-Oncogene Proteins c-akt | Sequence Homology, Amino Acid | Apoptosis Regulatory Proteins | Signal Transduction - physiology | Uterine Cervical Neoplasms - chemistry | Carcinoma - metabolism | Benzylamines - pharmacology | Isoenzymes - antagonists & inhibitors | Index Medicus | cdk2, cyclin-dependent kinase 2 | FGFR, fibroblast growth factor receptor | MEK, MAPK | SH, Src homology | PI3K, phosphoinositide 3-kinase | DOPS, 1,2-dioleoyl-sn-glycero-3-phospho-L-serine | ERK kinase | DOPC, 1,2-dioleoyl-sn-glycero-3-phosphocholine | DTT, dithiothreitol | PTEN, phosphatase and tensin homologue deleted on chromosome 10 | ERK, extracellular-signal-regulated kinase | PEG, poly(ethylene glycol) | PKC, protein kinase C | FLT, Fms-related tyrosine kinase | lymphoma 1 | GSK3, glycogen synthase kinase 3 | TRAIL, tumour-necrosis-factor-related apoptosis-inducing ligand | HTRF, homogeneous time-resolved fluorescence | PH, pleckstrin homology | MAPKK1, MAPK kinase 1 | FBS, foetal bovine serum | PDK, phosphoinositide-dependent kinase | TCL1, T-cell leukaemia | MAPK, mitogen-activated protein kinase | PKA, protein kinase A | SGK, serum- and glucocorticoid-inducible kinase
Journal Article
Methods in Molecular Biology, ISSN 1064-3745, 2017, Volume 1555, pp. 47 - 58
Journal Article
Biochemistry, ISSN 0006-2960, 06/2017, Volume 56, Issue 23, pp. 2938 - 2949
Journal Article
Journal of Physiology and Pharmacology, ISSN 0867-5910, 10/2015, Volume 66, Issue 5, pp. 701 - 709
Journal Article
Journal Article
Journal Article
FEBS Letters, ISSN 0014-5793, 06/2012, Volume 586, Issue 13, pp. 1759 - 1764
► Alix achieves a specific SH3 domains RT-loop selection. ► This selection is made through an extended linear ‘peptide-like’ binding mode. ► The proline rich... 
NMR | Src family kinase (SFK) | Src homology 3 domain (SH3 domain) | Apoptosis-linked gene 2-interacting protein X (Alix) | Protein–protein interaction | SAXS | PPII | haemopoietic | small-angle X-ray scattering | PDB | PRR | isothermal titration calorimetry | protein data bank | ALG-2 | heteronuclear single quantum coherence | ensemble optimization method | EOM | Alix | GST | polyproline type II | proline-rich region | Hck | Src family of non-receptor protein tyrosine kinases | apoptosis-linked-gene-2 | ALG-2 interacting protein X | glutathione S-transferase | ITC | HSQC | SFKs | Protein-protein interaction | ALIX/AIP1 | ANTAGONIZES | COMPLEX | SPECIFICITY | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | KINASE | CELL BIOLOGY | BIOPHYSICS | HIV-1 NEF PROTEIN | BINDING | Calcium-Binding Proteins - chemistry | Calcium-Binding Proteins - metabolism | Proline - metabolism | Humans | Cell Cycle Proteins - metabolism | Endosomal Sorting Complexes Required for Transport - metabolism | Models, Molecular | Proto-Oncogene Proteins c-hck - metabolism | Scattering, Small Angle | nef Gene Products, Human Immunodeficiency Virus - chemistry | src Homology Domains | Cell Cycle Proteins - chemistry | Proline - genetics | Proto-Oncogene Proteins c-hck - chemistry | Nuclear Magnetic Resonance, Biomolecular | nef Gene Products, Human Immunodeficiency Virus - metabolism | Protein Conformation | Endosomal Sorting Complexes Required for Transport - chemistry | Binding Sites | Tyrosine | Parrots | Glutathione transferase | Genes | Index Medicus | Organic chemistry | Chemical Sciences | protein-protein interaction | apoptosis-linked gene 2-interacting protein X (Alix)
Journal Article