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Molecular Cell, ISSN 1097-2765, 06/2018, Volume 70, Issue 6, pp. 995 - 1007.e11
Journal Article
Science's STKE : signal transduction knowledge environment, ISSN 1945-0877, 2003, Volume 2003, Issue 191, pp. RE12 - re12
Intracellular signaling pathways that involve protein tyrosine kinases (PTKs) are critical for the control of most cellular processes. Dysfunctions in PTKs, or... 
Protein-Tyrosine Kinases - physiology | Animals | Humans | Phosphotyrosine - physiology | Signal Transduction - physiology | src Homology Domains - physiology | Phosphotyrosine - metabolism | Protein Binding - physiology
Journal Article
Science's STKE : signal transduction knowledge environment, ISSN 1945-0877, 2003, Volume 2003, Issue 179, pp. RE8 - re8
One particularly abundant group of modular recognition domains consists of those that bind proline-rich motifs. Such modules, including the SH3, WW, and EVH1... 
Proline - physiology | Animals | Humans | Structure-Activity Relationship | src Homology Domains - physiology | Proline - chemistry | Protein Structure, Tertiary - physiology
Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 09/2005, Volume 390, Issue 3, pp. 641 - 653
Protein-protein interactions occurring via the recognition of short peptide sequences by modular interaction domains play a central role in the assembly of... 
Signal transduction | Proline-recognition domain | Src homology 3 domain (SH3 domain) | Proline-rich motif | Interaction domain | WW domain | BINDING MOTIF | PX DOMAIN | signal transduction | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | HIGH-AFFINITY | NADPH OXIDASE ACTIVATION | proline-rich motif | interaction domain | PROTEIN-PROTEIN INTERACTIONS | INTERACTION NETWORKS | proline-recognition domain | WW-DOMAINS | PEPTIDE RECOGNITION | SRC HOMOLOGY-3 DOMAIN | Animals | Signal Transduction | Proline - metabolism | Protein Binding | Substrate Specificity | src Homology Domains - physiology | Evolution, Molecular | SH, Src homology | EVH1, Enabled | PEP, proline-enriched phosphatase | SH3-C, C-terminal SH3 domain | VASP (vasodilator-stimulated protein) homology | Review | Csk, C-terminal Src kinase | CD2BP2, CD2-binding protein 2 | PTB, phosphotyrosine-binding | CDR, complementarity-determining region | Fyb, Fyn-binding protein | HOG, high-osmolarity glycerol | PPII, polyproline type II | PRD, proline-recognition domain | phox, phagocyte oxidase | SLAP130, SH2-domain-containing-leucocyte-protein-of-76-kDa-associated protein | CAP, cytoskeleton-associated protein | SLP-76, SH2-domain-containing leucocyte protein of 76 kDa | PB1, phox (phagocyte oxidase) and Bem1 | SAP, signalling-lymphocytic-activation-molecule-associated protein | PX, phox homology | UEV, ubiquitin E2 variant | SLAM, signalling lymphocytic activation molecule | PH, pleckstrin homology | STAM, signal transducing adaptor molecule | MAPK, mitogen-activated protein kinase
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 8/2012, Volume 109, Issue 35, pp. 14024 - 14029
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2011, Volume 286, Issue 50, pp. 43352 - 43360
Journal Article
Biochemical Pharmacology, ISSN 0006-2952, 2010, Volume 79, Issue 10, pp. 1398 - 1409
S3I-201.1066 binds to the Stat3 SH2 domain, disrupts aberrant Stat3 activation and Stat3 function, and induces antitumor effects in tumors harboring aberrant... 
Stat3 | S3I-201 | Antitumor cell effects | S3I-201.1066 | Small-molecule inhibitor | Antitumor effects | Surface Plasmon Resonance | DNA, Neoplasm - metabolism | Humans | Transcriptional Activation - drug effects | Receptor, Epidermal Growth Factor - drug effects | Breast Neoplasms - physiopathology | src Homology Domains - drug effects | Fluorescence Polarization Immunoassay | Benzenesulfonates - pharmacology | STAT3 Transcription Factor - physiology | Female | Gene Expression Regulation, Neoplastic - drug effects | Receptor, Epidermal Growth Factor - physiology | Gene Expression Regulation, Neoplastic - physiology | STAT3 Transcription Factor - genetics | STAT3 Transcription Factor - metabolism | Cell Line | Aminosalicylic Acids - pharmacology | src Homology Domains - physiology | Cell Transformation, Neoplastic - metabolism | DNA, Neoplasm - drug effects | Animals | Mice, Nude | STAT3 Transcription Factor - drug effects | Cell Line, Tumor | Mice | Transcriptional Activation - physiology | Cell Transformation, Neoplastic - drug effects | Pancreatic Neoplasms - physiopathology | STAT3 Transcription Factor - antagonists & inhibitors | TRANSCRIPTIONAL ACTIVITY | CONSTITUTIVE ACTIVATION | S3I-201 1066 | HUMAN PANCREATIC-CANCER | CONFERS RESISTANCE | DNA-BINDING ACTIVITY | POTENT ANTITUMOR-ACTIVITY | CELL-TRANSFORMATION | PHARMACOLOGY & PHARMACY | GROWTH-FACTOR | SRC ONCOPROTEIN | SIGNAL TRANSDUCER | Index Medicus | small-molecule inhibitor | antitumor effects | antitumor cell effects
Journal Article