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Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these... 
CELLCYCLE | SIGNALING | Oncology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer | Index Medicus
Journal Article
American Journal of Physiology: Cell Physiology, ISSN 1522-1563, 11/2007, Volume 293, Issue 5, pp. C1489 - C1497
.... In a dose- and time-dependent manner, ouabain activated Akt and phosphorylation of its substrates mammalian target of rapamycin and glycogen synthase kinase in neonatal rat cardiac myocytes... 
Heart failure | Growth factor receptor | Sodium pump | ATPase | Cardiac glycosides | Physiology | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Protein Kinases - metabolism | Phosphorylation | Phosphatidylinositol Phosphates - metabolism | Mitogen-Activated Protein Kinase 3 - antagonists & inhibitors | Ouabain - toxicity | Phosphatidylinositol 3-Kinases - metabolism | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Dose-Response Relationship, Drug | Myocytes, Cardiac - enzymology | Receptor, Epidermal Growth Factor - metabolism | Time Factors | Enzyme Inhibitors - toxicity | src-Family Kinases - metabolism | MAP Kinase Kinase Kinases - antagonists & inhibitors | Proto-Oncogene Proteins c-akt - metabolism | Animals, Newborn | Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors | Cell Size - drug effects | Mitogen-Activated Protein Kinase 1 - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Cells, Cultured | Rats | MAP Kinase Kinase Kinases - metabolism | Rats, Sprague-Dawley | Myocytes, Cardiac - pathology | Sodium-Potassium-Exchanging ATPase - metabolism | Animals | Myocytes, Cardiac - drug effects | Mitogen-Activated Protein Kinase 3 - metabolism | Signal Transduction - drug effects | Myocytes, Cardiac - metabolism | Receptor, Epidermal Growth Factor - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | TOR Serine-Threonine Kinases | Glycogen Synthase Kinases - metabolism | Hypertrophy | Mitogen-Activated Protein Kinase 1 - metabolism | Inhibitor drugs | Sodium | Kinases | Potassium | Adenosine triphosphatase | Cells | Index Medicus
Journal Article
Nature (London), ISSN 1476-4687, 06/2012, Volume 486, Issue 7401, pp. 80 - 84
The complexity of cancer has led to recent interest in polypharmacological approaches for developing kinase-inhibitor drugs... 
Science & Technology - Other Topics | Multidisciplinary Sciences | Science & Technology | Niacinamide - analogs & derivatives | Proto-Oncogene Proteins c-ret - metabolism | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Male | Phenylurea Compounds | Extracellular Signal-Regulated MAP Kinases - metabolism | Protein Kinase Inhibitors - adverse effects | Drosophila Proteins - metabolism | Molecular Targeted Therapy | Drosophila melanogaster - genetics | Heterocyclic Compounds, 4 or More Rings - pharmacology | Multiple Endocrine Neoplasia Type 2b - genetics | Multiple Endocrine Neoplasia Type 2b - enzymology | Benzenesulfonates - pharmacology | Multiple Endocrine Neoplasia Type 2b - drug therapy | Protein Kinase Inhibitors - chemistry | Polypharmacy | Heterocyclic Compounds, 4 or More Rings - therapeutic use | Drug-Related Side Effects and Adverse Reactions | src-Family Kinases - metabolism | Receptor Protein-Tyrosine Kinases - antagonists & inhibitors | Drug Evaluation, Preclinical | Drosophila Proteins - antagonists & inhibitors | Disease Models, Animal | src-Family Kinases - antagonists & inhibitors | Heterocyclic Compounds, 4 or More Rings - chemistry | Heterocyclic Compounds, 4 or More Rings - adverse effects | Survival Rate | Drosophila melanogaster - drug effects | Xenograft Model Antitumor Assays | Animals | Signal Transduction - drug effects | Protein Kinase Inhibitors - therapeutic use | Sorafenib | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Cell Transformation, Neoplastic - drug effects | Drosophila Proteins - genetics | Cell Transformation, Neoplastic - pathology | Proto-Oncogene Proteins c-ret - genetics | Chemotherapy | Physiological aspects | Genetic aspects | Cellular signal transduction | Research | Carcinogenesis | Risk factors | Cancer | Proteins | Nuclear magnetic resonance--NMR | Insects | Toxicity | Mutation | Kinases | Drug dosages | Cell adhesion & migration | Index Medicus
Journal Article
Current medicinal chemistry, ISSN 0929-8673, 11/2012, Volume 19, Issue 31, pp. 5294 - 5318
Protein kinases (PKs) and lipid kinases (LKs) are good choices for targets of signal transduction therapy as these enzymes are involved in signaling pathways, and are often related to the pathogenesis of lymphoid malignancies... 
Pharmacology & Pharmacy | Biochemistry & Molecular Biology | Life Sciences & Biomedicine | Chemistry, Medicinal | Science & Technology | Protein Kinases - metabolism | Cyclin-Dependent Kinases - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein Kinases - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Protein Kinase C - antagonists & inhibitors | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - therapy | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Protein Kinase Inhibitors - chemistry | Protein Kinase C - metabolism | Protein Kinase Inhibitors - therapeutic use | Agammaglobulinaemia Tyrosine Kinase | src-Family Kinases - metabolism | Cyclin-Dependent Kinases - antagonists & inhibitors | Syk Kinase | Protein-Tyrosine Kinases - antagonists & inhibitors | CLL | Vandetanib | PCI-32765 | Multikinase inhibitors | Bafetinib | Ibrutinib | R406 | AVL-292 | GDC-0834 | Sunitinib | BAY-61-3606 | NHL | PI3K | AG013736 | Fostamatinib | Axitinib | C-61 | SKI-606 | Pazopanib | Lyn | Dasatinib | CAL-101 | Syk | Cyclin-dependent kinases | SU6656 | Bosutinib | Tyrosine kinase inhibitors | Flavopiridol | PP2 | Sorafenib | Btk | TKI258 | Drugs | Spleen | Attraction | Enzymes | Chronic lymphatic leukemia | Imatinib | Toxicity | Clinical trials | Malignancy | Chronic myeloid leukemia | B-cell receptor | Bruton's tyrosine kinase | Cell surface | 1-Phosphatidylinositol 3-kinase | Cyclin-dependent kinase | Signal transduction | Active sites | Lipid kinase | Protein-tyrosine kinase | flavopiridol
Journal Article
Cell stress & chaperones, ISSN 1466-1268, 11/2016, Volume 22, Issue 1, pp. 123 - 134
Reactive oxygen species damage various cell components including DNA, proteins, and lipids, and these impairments could be a reason for severe human diseases... 
Hep G2 cells | Oxidative stress | Transcription factors | Hepatocytes | Hydrogen | Genes | Cell lines | Small interfering RNA | Peroxides | Gene expression | Biomedicine, general | Biochemistry, general | Neurosciences | Biomedicine | Immunology | Hydrogen peroxide | Apolipoprotein A-I | LXRα | Cancer Research | FOXO1 | Cell Biology | Life Sciences & Biomedicine | Science & Technology | AMP-Activated Protein Kinases - metabolism | Liver X Receptors - antagonists & inhibitors | Humans | JNK Mitogen-Activated Protein Kinases - metabolism | Apolipoprotein A-I - genetics | RNA Interference | src-Family Kinases - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Hydrogen Peroxide - toxicity | Forkhead Box Protein O1 - metabolism | JNK Mitogen-Activated Protein Kinases - antagonists & inhibitors | AMP-Activated Protein Kinases - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Liver X Receptors - metabolism | Apolipoprotein A-I - metabolism | Down-Regulation - drug effects | Hep G2 Cells | Up-Regulation - drug effects | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Protein Kinase Inhibitors - pharmacology | Oxidative Stress - drug effects | Forkhead Box Protein O1 - antagonists & inhibitors | Forkhead Box Protein O1 - genetics | AMP-Activated Protein Kinases - genetics | Liver X Receptors - genetics | RNA, Small Interfering - metabolism | Index Medicus | Original Paper
Journal Article
Cancer discovery, ISSN 2159-8290, 02/2013, Volume 3, Issue 2, pp. 158 - 167
Journal Article
Oncogene, ISSN 0950-9232, 04/2003, Volume 22, Issue 15, pp. 2272 - 2284
.... In addition to PKC, active Src kinase was also shown to be involved in the maintenance of Raf-independent ERK activation... 
PKC | Cell survival | MAPK | Src | Hairy-cell leukemia | Biochemistry & Molecular Biology | Oncology | Genetics & Heredity | Life Sciences & Biomedicine | Science & Technology | Cell Biology | Neoplastic Stem Cells - cytology | Apoptosis - drug effects | Protein-Tyrosine Kinases - metabolism | Clone Cells - enzymology | Humans | Mitogen-Activated Protein Kinase Kinases - physiology | Drug Resistance, Neoplasm | Neoplasm Proteins - antagonists & inhibitors | Vitronectin | MAP Kinase Kinase 2 | MAP Kinase Kinase 1 | Mitogen-Activated Protein Kinase Kinases - metabolism | MAP Kinase Kinase 4 | Culture Media | Antimetabolites, Antineoplastic - pharmacology | src-Family Kinases - physiology | p38 Mitogen-Activated Protein Kinases | Protein-Serine-Threonine Kinases - metabolism | B-Lymphocytes - cytology | Protein Kinase C - physiology | Mitogen-Activated Protein Kinase 1 - physiology | Enzyme Inhibitors - pharmacology | Cell Adhesion | Tumor Necrosis Factor-alpha - pharmacology | Neoplastic Cells, Circulating | Protein Processing, Post-Translational | Protein-Tyrosine Kinases - antagonists & inhibitors | Clone Cells - cytology | Phosphorylation | Neoplasm Proteins - physiology | MAP Kinase Signaling System | Tumor Cells, Cultured - enzymology | Protein-Serine-Threonine Kinases - antagonists & inhibitors | JNK Mitogen-Activated Protein Kinases | Leukemia, Hairy Cell - pathology | Leukemia, Hairy Cell - enzymology | Isoenzymes - physiology | B-Lymphocytes - enzymology | Cell Survival | Mitogen-Activated Protein Kinase Kinases - antagonists & inhibitors | Protein Kinase C - antagonists & inhibitors | Enzyme Activation - drug effects | Cladribine - pharmacology | Mitogen-Activated Protein Kinase 8 | Mitogen-Activated Protein Kinase 9 | Mitogen-Activated Protein Kinases - physiology | Neoplastic Stem Cells - enzymology | Isoenzymes - antagonists & inhibitors | Mitogen-Activated Protein Kinase 3 | Index Medicus
Journal Article
Journal Article