X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
humans (4244) 4244
animals (4206) 4206
src-family kinases - metabolism (3654) 3654
phosphorylation (2682) 2682
mice (2592) 2592
signal transduction (2020) 2020
cell biology (1818) 1818
biochemistry & molecular biology (1799) 1799
src-family kinases - genetics (1529) 1529
activation (1391) 1391
oncology (1156) 1156
cell line, tumor (1141) 1141
src-family kinases (1122) 1122
protein-tyrosine kinases - metabolism (1058) 1058
cell line (969) 969
cells, cultured (969) 969
female (961) 961
src (960) 960
src-family kinases - antagonists & inhibitors (948) 948
expression (935) 935
male (878) 878
kinases (843) 843
proteins (833) 833
c-src (777) 777
enzyme activation (703) 703
tyrosine (703) 703
rats (688) 688
cancer (683) 683
research (680) 680
transfection (662) 662
mice, knockout (650) 650
protein-tyrosine kinases - genetics (649) 649
signal transduction - drug effects (643) 643
src family kinases (630) 630
tyrosine kinase (628) 628
immunology (622) 622
mutation (617) 617
molecular sequence data (607) 607
amino acid sequence (600) 600
protein binding (591) 591
tyrosine - metabolism (575) 575
tyrosine phosphorylation (575) 575
signal transduction - physiology (572) 572
apoptosis (542) 542
mice, inbred c57bl (538) 538
signal-transduction (516) 516
research article (506) 506
gene expression (499) 499
protein (493) 493
multidisciplinary sciences (489) 489
src-family kinases - physiology (470) 470
cells (465) 465
proto-oncogene proteins - metabolism (458) 458
protein kinase inhibitors - pharmacology (453) 453
physiological aspects (444) 444
cell proliferation (439) 439
pyrimidines - pharmacology (438) 438
focal adhesion kinase (418) 418
phosphorylation - drug effects (416) 416
genetic aspects (402) 402
enzyme inhibitors - pharmacology (395) 395
protein-tyrosine kinase (386) 386
blotting, western (385) 385
receptor (383) 383
genetics & heredity (370) 370
hematology (363) 363
phosphatidylinositol 3-kinases - metabolism (361) 361
analysis (351) 351
metastasis (344) 344
models, biological (339) 339
phosphotransferases (335) 335
family kinases (328) 328
medicine (327) 327
proto-oncogene proteins - genetics (327) 327
biology (318) 318
cell movement (316) 316
rna interference (312) 312
binding sites (307) 307
in-vivo (304) 304
tumor cells, cultured (304) 304
src homology domains (301) 301
cell adhesion (300) 300
binding (295) 295
inhibition (293) 293
proto-oncogene proteins c-akt - metabolism (293) 293
growth (292) 292
gene expression regulation, neoplastic (288) 288
growth-factor receptor (286) 286
science (286) 286
tyrosine kinases (286) 286
health aspects (284) 284
receptor, epidermal growth factor - metabolism (283) 283
signaling (282) 282
time factors (280) 280
down-regulation (279) 279
kinase (279) 279
neurosciences (279) 279
src protein (279) 279
breast cancer (278) 278
cell proliferation - drug effects (277) 277
more...
Library Location Library Location
Language Language
Language Language
X
Sort by Item Count (A-Z)
Filter by Count
English (6485) 6485
Japanese (35) 35
Chinese (12) 12
Russian (8) 8
French (5) 5
German (4) 4
Italian (1) 1
Norwegian (1) 1
Portuguese (1) 1
Swedish (1) 1
more...
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


Nature (London), ISSN 1476-4687, 2016, Volume 534, Issue 7605, pp. 55 - 62
Somatic mutations have been extensively characterized in breast cancer, but the effects of these genetic alterations on the proteomic landscape remain poorly understood... 
PATHWAYS | HETEROGENEITY | PIK3CA MUTATIONS | PHOSPHORYLATION | MULTIDISCIPLINARY SCIENCES | GENES | BIOLOGY | RECEPTOR | EXPRESSION | SIGNATURE | REVEALS | Protein Kinases - metabolism | Focal Adhesion Kinase 1 - genetics | Receptor, Epidermal Growth Factor - genetics | Protein Kinases - genetics | Cyclin-Dependent Kinases - metabolism | Receptor, ErbB-2 - genetics | Receptors, G-Protein-Coupled - metabolism | Genomics | Humans | Gene Expression Regulation, Neoplastic | Receptor, ErbB-2 - metabolism | Phosphoproteins - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - genetics | Tumor Suppressor Protein p53 - genetics | Breast Neoplasms - metabolism | Receptor-Interacting Protein Serine-Threonine Kinase 2 - metabolism | Breast Neoplasms - enzymology | Receptor, Epidermal Growth Factor - metabolism | Phosphoproteins - analysis | Mass Spectrometry | src-Family Kinases - metabolism | Female | Cyclin-Dependent Kinases - genetics | Focal Adhesion Kinase 1 - metabolism | Chromosomes, Human, Pair 5 - genetics | Breast Neoplasms - classification | Chromosome Deletion | p21-Activated Kinases - genetics | Signal Transduction | Molecular Sequence Annotation | Calcium-Binding Proteins - deficiency | Phosphoproteins - genetics | Mutation - genetics | S-Phase Kinase-Associated Proteins - metabolism | p21-Activated Kinases - metabolism | Phosphatidylinositol 3-Kinases - genetics | Breast Neoplasms - genetics | Class I Phosphatidylinositol 3-Kinases | Proteomics | S-Phase Kinase-Associated Proteins - genetics | Receptors, G-Protein-Coupled - genetics | src-Family Kinases - genetics | Calcium-Binding Proteins - genetics | Breast cancer | Genetic aspects | Research | Oncology, Experimental | Cancer | Physiological aspects | Methods | Mutation (Biology) | Proteins | Gene amplification | Peptides | Protein expression | Genomes | Mutation | Kinases | Deoxyribonucleic acid--DNA | Tumors
Journal Article
Cancer cell, ISSN 1535-6108, 2010, Volume 17, Issue 6, pp. 547 - 559
In mice, Lkb1 deletion and activation of Kras G12D results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these... 
CELLCYCLE | SIGNALING | INACTIVATION | SUPPRESSOR | SIGNATURES | ONCOLOGY | SRC | ADENOCARCINOMA | SENSITIVITY | MUTATIONS | LKB1/STK11 | EXPRESSION | TUMORIGENESIS | CELL BIOLOGY | Lung Neoplasms - drug therapy | Protein-Serine-Threonine Kinases - deficiency | Protein-Tyrosine Kinases - metabolism | Proto-Oncogene Proteins p21(ras) - genetics | Genomics | Humans | Lung Neoplasms - metabolism | Gene Expression Profiling | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Cell Movement - genetics | Phosphorylation - genetics | RNA Interference | Gene Expression Regulation, Neoplastic - genetics | MAP Kinase Kinase 1 - antagonists & inhibitors | Carcinoma, Non-Small-Cell Lung - metabolism | Signal Transduction - genetics | Enzyme Inhibitors - therapeutic use | Focal Adhesion Protein-Tyrosine Kinases - antagonists & inhibitors | Focal Adhesion Protein-Tyrosine Kinases - genetics | Focal Adhesions - genetics | Signal Transduction - drug effects | Mice, Nude | Cell Line, Tumor | Mice | TOR Serine-Threonine Kinases | src-Family Kinases - genetics | Protein-Tyrosine Kinases - antagonists & inhibitors | ras Proteins - genetics | Lung Neoplasms - pathology | Cell Transdifferentiation - genetics | Protein-Tyrosine Kinases - genetics | Neoplasm Metastasis - drug therapy | Mice, Mutant Strains | Protein-Serine-Threonine Kinases - antagonists & inhibitors | src-Family Kinases - metabolism | Female | Drug Therapy, Combination | Lung Neoplasms - genetics | Cell Adhesion - genetics | Carcinoma, Non-Small-Cell Lung - genetics | Focal Adhesion Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Protein-Serine-Threonine Kinases - genetics | Proto-Oncogene Proteins - genetics | Up-Regulation - genetics | Xenograft Model Antitumor Assays | Neoplasm Metastasis - genetics | Animals | MAP Kinase Kinase 2 - antagonists & inhibitors | Protein Kinase Inhibitors - therapeutic use | Focal Adhesions - metabolism | Proteomics | Protein Kinase Inhibitors - pharmacology | Oncology, Experimental | Analysis | Lung cancer | Development and progression | Metastasis | Research | Cancer
Journal Article
Blood, ISSN 1528-0020, 2017, Volume 129, Issue 6, pp. 759 - 770
Contrasting patterns of basal phosphorylation levels and α-BCR–induced signaling between CLL and MCL tumors. Direct association between BCR-induced signaling... 
SURFACE IGM | BCR | CHRONIC-LYMPHOCYTIC-LEUKEMIA | BRUTONS TYROSINE KINASE | HUMAN FOLLICULAR LYMPHOMA | GENE-EXPRESSION | KINASE INHIBITOR IBRUTINIB | MUTATIONS | TARGETING BTK | HEMATOLOGY | NF-KAPPA-B | Lymphoma, Follicular - metabolism | Protein-Tyrosine Kinases - metabolism | Humans | Lymphoma, Mantle-Cell - pathology | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Receptors, Antigen, B-Cell - metabolism | STAT1 Transcription Factor - metabolism | Lymphoma, Follicular - genetics | Mitogen-Activated Protein Kinase 1 - genetics | p38 Mitogen-Activated Protein Kinases - metabolism | Proto-Oncogene Proteins c-akt - metabolism | Single-Cell Analysis | Immunoglobulin M - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | STAT1 Transcription Factor - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Lymphoma, Large B-Cell, Diffuse - diagnosis | Mitogen-Activated Protein Kinase 3 - metabolism | Leukemia, Lymphocytic, Chronic, B-Cell - metabolism | Receptors, Antigen, B-Cell - genetics | CD79 Antigens - genetics | src-Family Kinases - genetics | Mitogen-Activated Protein Kinase 1 - metabolism | Phosphorylation | Gene Expression Regulation, Neoplastic | Lymphoma, Follicular - diagnosis | Lymphoma, Large B-Cell, Diffuse - metabolism | Phosphoproteins - metabolism | Proto-Oncogene Proteins c-akt - genetics | Lymphoma, Mantle-Cell - diagnosis | STAT5 Transcription Factor - genetics | STAT5 Transcription Factor - metabolism | Protein-Tyrosine Kinases - genetics | Flow Cytometry | Syk Kinase - genetics | Phospholipase C gamma - genetics | src-Family Kinases - metabolism | Lymphoma, Mantle-Cell - genetics | Lymphoma, Mantle-Cell - metabolism | Diagnosis, Differential | Phospholipase C gamma - metabolism | Lymphoma, Large B-Cell, Diffuse - pathology | Lymphoma, Follicular - pathology | p38 Mitogen-Activated Protein Kinases - genetics | Phosphoproteins - genetics | CD79 Antigens - metabolism | Syk Kinase - metabolism | Lymphoma, Large B-Cell, Diffuse - genetics | Leukemia, Lymphocytic, Chronic, B-Cell - diagnosis | Life Sciences | Human health and pathology | Hematology | Cancer | Lymphoid Neoplasia
Journal Article
Biochemical journal, ISSN 0264-6021, 02/2017, Volume 474, Issue 4, pp. 597 - 609
.... PDE4 long isoforms can be phosphorylated by mitogen-activated protein kinase-activated protein kinase 2 (MK2... 
CELLS | SIGNALING PATHWAYS | ACTIVATION | CAMP-SPECIFIC PHOSPHODIESTERASE | PROTEIN-KINASE | MAP KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | A-MEDIATED PHOSPHORYLATION | BETA-ARRESTIN | BINDING-SITES | ROLIPRAM INHIBITION | Humans | Cyclic AMP-Dependent Protein Kinases - chemistry | Intracellular Signaling Peptides and Proteins - metabolism | Cyclic AMP-Dependent Protein Kinases - genetics | Mitogen-Activated Protein Kinase 1 - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - metabolism | Cyclic Nucleotide Phosphodiesterases, Type 4 - chemistry | Intracellular Signaling Peptides and Proteins - genetics | 1-Alkyl-2-acetylglycerophosphocholine Esterase - chemistry | Protein-Serine-Threonine Kinases - metabolism | Gene Expression | Mitogen-Activated Protein Kinase 3 - genetics | Signal Transduction | Recombinant Proteins - chemistry | Ubiquitin-Conjugating Enzymes - genetics | Cyclic Nucleotide Phosphodiesterases, Type 4 - genetics | Mitogen-Activated Protein Kinase 3 - metabolism | Ubiquitin-Conjugating Enzymes - metabolism | Molecular Docking Simulation | Protein-Serine-Threonine Kinases - chemistry | src-Family Kinases - genetics | COS Cells | Mitogen-Activated Protein Kinase 1 - metabolism | Microtubule-Associated Proteins - chemistry | Microtubule-Associated Proteins - genetics | Microtubule-Associated Proteins - metabolism | beta-Arrestins - metabolism | Cercopithecus aethiops | Ubiquitin-Conjugating Enzymes - chemistry | Mitogen-Activated Protein Kinase 1 - chemistry | 1-Alkyl-2-acetylglycerophosphocholine Esterase - genetics | HEK293 Cells | src-Family Kinases - metabolism | Protein Interaction Domains and Motifs | Mitogen-Activated Protein Kinase 3 - chemistry | beta-Arrestins - chemistry | Cyclic AMP-Dependent Protein Kinases - metabolism | Recombinant Proteins - metabolism | Catalytic Domain | Protein Structure, Secondary | Protein-Serine-Threonine Kinases - genetics | Recombinant Proteins - genetics | Amino Acid Motifs | 1-Alkyl-2-acetylglycerophosphocholine Esterase - metabolism | beta-Arrestins - genetics | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Protein Binding | src-Family Kinases - chemistry | protein–protein interactions | cAMP | cyclic nucleotide phosphodiesterases
Journal Article
Blood, ISSN 1528-0020, 2010, Volume 115, Issue 23, pp. 4951 - 4962
.... Sequential activation of Src, mitogen-activated protein kinases (MAPKs), and phosphatidylinositol-3... 
PROTEIN-KINASE-C | SIGNALING PATHWAYS | ENDOTHELIAL-CELLS | COCAINE | CHEMOATTRACTANT PROTEIN-1 | HUMAN-IMMUNODEFICIENCY-VIRUS | CHEMOKINE RECEPTORS | HEMATOLOGY | BLOOD-BRAIN-BARRIER | NF-KAPPA-B | HIV-1 INVASION | HIV-1 | Microglia - metabolism | Mitogen-Activated Protein Kinase Kinases - genetics | Dopamine Uptake Inhibitors - adverse effects | Membrane Microdomains - metabolism | Male | Monocytes - metabolism | NF-kappa B - metabolism | Phosphatidylinositol 3-Kinases - metabolism | Cocaine-Related Disorders - genetics | Cell Movement - genetics | Brain - metabolism | Mitogen-Activated Protein Kinase Kinases - metabolism | Cocaine-Related Disorders - metabolism | MAP Kinase Signaling System - genetics | HIV Infections - pathology | Monocytes - pathology | src-Family Kinases - metabolism | Microglia - pathology | Chemokine CCL2 - metabolism | Cocaine - adverse effects | Receptors, sigma - metabolism | Neurodegenerative Diseases - pathology | Dopamine Uptake Inhibitors - pharmacology | Gene Expression Regulation - genetics | HIV Infections - genetics | Cocaine-Related Disorders - pathology | Rats | Chemokine CCL2 - genetics | Neurodegenerative Diseases - genetics | Receptors, sigma - genetics | Neurodegenerative Diseases - metabolism | Mice, Knockout | Gene Expression Regulation - drug effects | Phosphatidylinositol 3-Kinases - genetics | Cell Movement - drug effects | Cocaine - pharmacology | Animals | MAP Kinase Signaling System - drug effects | Neurodegenerative Diseases - chemically induced | NF-kappa B - genetics | Brain - pathology | Mice | src-Family Kinases - genetics | Membrane Microdomains - pathology | Membrane Microdomains - genetics | HIV Infections - metabolism | Vascular Biology | HIV Infections | Membrane Microdomains | Brain | pathology | src-Family Kinases | Cocaine-Related Disorders | Phosphatidylinositol 3-Kinases | MAP Kinase Signaling System | Receptors | genetics | Mitogen-Activated Protein Kinase Kinases | NF-kappa B | pharmacology | Dopamine Uptake Inhibitors | sigma | Neurodegenerative Diseases | chemically induced | Gene Expression Regulation | Cell and Molecular Biology | drug effects | Knockout | Microglia | Monocytes | adverse effects | metabolism | Cocaine | Chemokine CCL2 | Cell- och molekylärbiologi | Cell Movement
Journal Article
Cell death and differentiation, ISSN 1350-9047, 09/2012, Volume 19, Issue 9, pp. 1459 - 1469
Src, the canonical member of the non-receptor family of tyrosine kinases, is deregulated in numerous cancers, including colon and breast cancers... 
Erk1/2 | proteasome | apoptosis | Bik | Src | Bim | SURVIVAL | ACTIVATION | PHOSPHORYLATION | RAS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BCL-2 FAMILY PROTEINS | CELL BIOLOGY | GENE | SIGNALING PATHWAY | BAX | V-SRC | CANCER CELL-LINES | Neoplasms - metabolism | NIH 3T3 Cells | Humans | Mitochondrial Proteins - genetics | raf Kinases - metabolism | Oncogene Protein p21(ras) - metabolism | MAP Kinase Signaling System | MAP Kinase Kinase 1 - genetics | Neoplasms - genetics | Mitochondrial Proteins - metabolism | Proteolysis | Mitogen-Activated Protein Kinase 1 - genetics | src-Family Kinases - metabolism | Apoptosis Regulatory Proteins - genetics | Membrane Proteins - metabolism | raf Kinases - genetics | MAP Kinase Kinase 2 - genetics | Mitogen-Activated Protein Kinase 3 - genetics | Membrane Proteins - genetics | Enzyme Inhibitors - pharmacology | MAP Kinase Kinase 1 - metabolism | MAP Kinase Kinase 2 - metabolism | Enzyme Activation - drug effects | Apoptosis Regulatory Proteins - metabolism | Drug Resistance, Neoplasm - genetics | Animals | Mitogen-Activated Protein Kinase 3 - metabolism | Adaptor Proteins, Signal Transducing - genetics | Cell Line, Tumor | Thapsigargin - pharmacology | Mice | Adaptor Proteins, Signal Transducing - metabolism | Enzyme Activation - genetics | Neoplasms - pathology | src-Family Kinases - genetics | Staurosporine - pharmacology | Drug Resistance, Neoplasm - drug effects | Mitogen-Activated Protein Kinase 1 - metabolism | Oncogene Protein p21(ras) - genetics | Erk1 | Original Paper
Journal Article
EMBO reports, ISSN 1469-221X, 01/2013, Volume 14, Issue 1, pp. 65 - 72
.... Using Drosophila genetics, we show that the oncoprotein Src controls tumour microenvironment by Jun N‐terminal kinase (JNK... 
Src | JNK | Hippo pathway | Src; JNK | F-ACTIN | APOPTOSIS | TUMOR PROGRESSION | PROTEIN-KINASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | FAMILY KINASES | CELL-PROLIFERATION | CELL BIOLOGY | ORGAN SIZE | ONCOGENIC RAS | SIGNALING PATHWAY | GROWTH | Humans | Actins - metabolism | Tumor Microenvironment | Intracellular Signaling Peptides and Proteins - metabolism | Drosophila Proteins - metabolism | Drosophila melanogaster - genetics | Actins - genetics | Drosophila melanogaster - metabolism | MAP Kinase Kinase 4 - metabolism | Cell Transformation, Neoplastic - genetics | Trans-Activators - genetics | src-Family Kinases - metabolism | Larva - genetics | Nuclear Proteins - genetics | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Larva - metabolism | Cells, Cultured | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Cell Communication | Nuclear Proteins - metabolism | Cell Transformation, Neoplastic - metabolism | Animals | Models, Biological | MAP Kinase Kinase 4 - genetics | Protein Binding | Mitogen-Activated Protein Kinases - genetics | Trans-Activators - metabolism | Drosophila Proteins - genetics | src-Family Kinases - genetics | Mitogen-Activated Protein Kinases - metabolism | Proteins | Cellular biology | Insects | Genetics | Mutation | Kinases | Tumors | Scientific Reports
Journal Article
PLoS genetics, ISSN 1553-7404, 2010, Volume 6, Issue 2, p. e1000841
Journal Article
Nature cell biology, ISSN 1476-4679, 2004, Volume 6, Issue 2, pp. 154 - 161
Journal Article