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1. Full Text B cell-specific loss of lyn kinase leads to autoimmunity
by Lamagna, Chrystelle and Hu, Yongmei and DeFranco, Anthony L and Lowell, Clifford A
The Journal of immunology (1950), ISSN 0022-1767, 02/2014, Volume 192, Issue 3, pp. 919 - 928
Life Sciences & Biomedicine | Immunology | Science & Technology | T-Lymphocyte Subsets - immunology | Antibody Specificity | Antibodies, Antinuclear - biosynthesis | Myeloproliferative Disorders - enzymology | Immune Complex Diseases - immunology | Spleen - immunology | Kidney - pathology | Antibodies, Antinuclear - immunology | Cell Count | Germinal Center - immunology | Kidney - immunology | Homeostasis | Myeloproliferative Disorders - immunology | Immunoglobulin M - immunology | Myeloproliferative Disorders - genetics | src-Family Kinases - deficiency | Lupus Nephritis - etiology | Immunoglobulin G - biosynthesis | Autoimmunity - immunology | Immunoglobulin G - immunology | Myeloid Differentiation Factor 88 - immunology | Calcium Signaling - immunology | Spleen - pathology | Immunoglobulin Class Switching | Disease Models, Animal | B-Lymphocytes - enzymology | Lymphocyte Activation | Mice, Inbred C57BL | Mice, Transgenic | Lupus Nephritis - immunology | Germinal Center - pathology | Organ Specificity | src-Family Kinases - immunology | Immune Complex Diseases - pathology | Antibodies, Antinuclear - genetics | Lupus Nephritis - enzymology | Animals | B-Lymphocytes - immunology | Myeloid Differentiation Factor 88 - deficiency | Lymphopoiesis - immunology | Mice | src-Family Kinases - genetics | Immunoglobulin M - biosynthesis | Plasma Cells - immunology | Index Medicus | Abridged Index Medicus
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2. Full Text Immobilized immune complexes induce neutrophil extracellular trap release by human neutrophil granulocytes via FcγRIIIB and Mac-1
by Behnen, Martina and Leschczyk, Christoph and Möller, Sonja and Batel, Tobit and Klinger, Matthias and Solbach, Werner and Laskay, Tamás
The Journal of immunology (1950), ISSN 0022-1767, 08/2014, Volume 193, Issue 4, pp. 1954 - 1965
Life Sciences & Biomedicine | Immunology | Science & Technology | Reactive Oxygen Species - metabolism | Nitriles - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - immunology | Macrophage-1 Antigen - immunology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, IgG - antagonists & inhibitors | Protein-Tyrosine Kinases - immunology | Lymphocyte Function-Associated Antigen-1 - immunology | Macrophage-1 Antigen - metabolism | Syk Kinase | CD11a Antigen - metabolism | Butadienes - pharmacology | Neutrophil Activation - immunology | GPI-Linked Proteins - immunology | Cell Degranulation | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Autoimmune Diseases - immunology | Cells, Cultured | Neutrophils - immunology | Imidazoles - pharmacology | Inflammation - immunology | Antioxidants - pharmacology | Onium Compounds - pharmacology | Pyrimidines - pharmacology | Receptors, IgG - immunology | src-Family Kinases - immunology | CD18 Antigens - metabolism | Mesalamine - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Aminopyrine - pharmacology | Ascorbic Acid - pharmacology | Pyridines - pharmacology | Antigen-Antibody Complex - immunology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus
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3. Tyrosine kinases and inflammatory signalling
by Page, Theresa H and Smolinska, Maria and Gillespie, Justin and Urbaniak, Anna M and Foxwell, Brian M.J
Current molecular medicine, ISSN 1566-5240, 2009, Volume 9, Issue 1, pp. 69 - 85
Tyrosine kinases | Inflammation | Cytokines | Rheumatoid Arthritis | Macrophages | Life Sciences & Biomedicine | Medicine, Research & Experimental | Science & Technology | Research & Experimental Medicine | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Janus Kinases - metabolism | Proto-Oncogene Proteins c-hck - immunology | Protein-Tyrosine Kinases - immunology | Cell Movement - immunology | Signal Transduction - immunology | Focal Adhesion Kinase 2 - metabolism | Adjuvants, Immunologic - metabolism | Gene Expression - immunology | Protein-Tyrosine Kinases - chemistry | src-Family Kinases - metabolism | Janus Kinases - immunology | Antigen-Antibody Complex - metabolism | Toll-Like Receptors - metabolism | Syk Kinase | Cytokines - immunology | Janus Kinases - chemistry | Cytokines - metabolism | Toll-Like Receptors - immunology | Proto-Oncogene Proteins c-hck - metabolism | Inflammation - immunology | src-Family Kinases - immunology | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Focal Adhesion Kinase 2 - chemistry | Mice | Antigen-Antibody Complex - immunology | src-Family Kinases - chemistry | Chronic Disease | Cytokines - biosynthesis | Focal Adhesion Kinase 2 - immunology
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4. Full Text Distinct Roles for Neutrophils and Dendritic Cells in Inflammation and Autoimmunity in motheaten Mice
by Abram, Clare L and Roberge, Gray L and Pao, Lily I and Neel, Benjamin G and Lowell, Clifford A
Immunity (Cambridge, Mass.), ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 489 - 501
Life Sciences & Biomedicine | Immunology | Science & Technology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Calgranulin A - metabolism | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | Autoimmunity - genetics | Immunoblotting | Intracellular Signaling Peptides and Proteins - immunology | Male | Intracellular Signaling Peptides and Proteins - metabolism | Calgranulin A - genetics | Mice, 129 Strain | CD11c Antigen - immunology | Protein-Tyrosine Kinases - immunology | CD11c Antigen - metabolism | Inflammation - metabolism | CD11c Antigen - genetics | Flow Cytometry | Autoimmunity - immunology | Myeloid Differentiation Factor 88 - immunology | src-Family Kinases - metabolism | Female | Calgranulin A - immunology | Neutrophils - metabolism | Syk Kinase | Dendritic Cells - metabolism | Dermis - metabolism | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Neutrophils - immunology | Mice, Transgenic | Inflammation - immunology | src-Family Kinases - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Dermis - immunology | Mice, Knockout | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Cell Line, Tumor | Inflammation - genetics | Dermis - pathology | Mice | Mutation | Myeloid Differentiation Factor 88 - metabolism | Autoimmunity | Dendritic cells | Analysis | Skin diseases | Inflammation | Phosphotransferases | Integrins | Index Medicus
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5. Full Text Integrin CD11b negatively regulates TLR-triggered inflammatory responses by activating Syk and promoting degradation of MyD88 and TRIF via Cbl-b
by Liu, Haibo and Jin, Jing and Cao, Xuetao and Xu, Sheng and Han, Chaofeng and Li, Nan
Nature immunology, ISSN 1529-2908, 08/2010, Volume 11, Issue 8, pp. 734 - 742
Life Sciences & Biomedicine | Immunology | Science & Technology | Proto-Oncogene Proteins c-cbl - metabolism | Protein-Tyrosine Kinases - metabolism | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Adaptor Proteins, Vesicular Transport - metabolism | Protein-Tyrosine Kinases - immunology | Myeloid Differentiation Factor 88 - immunology | Adaptor Proteins, Signal Transducing - immunology | Syk Kinase | Macrophages - immunology | CD11b Antigen - immunology | Signal Transduction | Toll-Like Receptors - immunology | Escherichia coli - immunology | Inflammation - immunology | Adaptor Proteins, Vesicular Transport - immunology | src-Family Kinases - immunology | Mice, Knockout | Gene Expression Regulation, Enzymologic | Immunity, Innate - immunology | Animals | Escherichia coli Infections - immunology | Mice | Enzyme Activation | Adaptor Proteins, Signal Transducing - metabolism | Inflammation - enzymology | Myeloid Differentiation Factor 88 - metabolism | Proto-Oncogene Proteins c-cbl - immunology | Cell receptors | Immune response | Cell adhesion | Physiological aspects | Research | Health aspects | Integrins | Index Medicus
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6. Full Text Role of TLR4 Tyrosine Phosphorylation in Signal Transduction and Endotoxin Tolerance
by Andrei E. Medvedev and Wenji Piao and Joanna Shoenfelt and Sang Hoon Rhee and Haiyan Chen and Subhendu Basu and Larry M. Wahl and Matthew J. Fenton and Stefanie N. Vogel
The Journal of biological chemistry, ISSN 0021-9258, 06/2007, Volume 282, Issue 22, pp. 16042 - 16053
Life Sciences & Biomedicine | Biochemistry & Molecular Biology | Science & Technology | Phosphorylation | I-kappa B Proteins - immunology | Humans | Amino Acid Substitution - immunology | NF-kappa B - immunology | MAP Kinase Kinase 4 - immunology | NF-kappa B - metabolism | I-kappa B Proteins - metabolism | Lipopolysaccharides - immunology | MAP Kinase Kinase 4 - metabolism | Myeloid Differentiation Factor 88 - immunology | src-Family Kinases - metabolism | p38 Mitogen-Activated Protein Kinases - metabolism | Immune Tolerance - drug effects | Lipopolysaccharide Receptors - biosynthesis | Cell Line | NF-KappaB Inhibitor alpha | Toll-Like Receptor 4 - genetics | Lipopolysaccharide Receptors - immunology | Signal Transduction - genetics | Toll-Like Receptor 4 - immunology | p38 Mitogen-Activated Protein Kinases - immunology | Lymphocyte Antigen 96 - biosynthesis | src-Family Kinases - immunology | Toll-Like Receptor 2 - biosynthesis | Toll-Like Receptor 4 - metabolism | Sequence Homology, Amino Acid | Animals | Signal Transduction - drug effects | Lipopolysaccharides - pharmacology | Immune Tolerance - genetics | Toll-Like Receptor 2 - immunology | Mutation, Missense - immunology | Signal Transduction - physiology | Mice | Myeloid Differentiation Factor 88 - metabolism | Lymphocyte Antigen 96 - immunology | Index Medicus
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7. Full Text The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse
by Jenkins, Misty R and Tsun, Andy and Stinchcombe, Jane C and Griffiths, Gillian M
Immunity (Cambridge, Mass.), ISSN 1074-7613, 10/2009, Volume 31, Issue 4, pp. 621 - 631
MOLIMMUNO | CELLIMMUNO | Life Sciences & Biomedicine | Immunology | Science & Technology | Ovalbumin - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Immunological Synapses - metabolism | Extracellular Signal-Regulated MAP Kinases - immunology | Centrosome - ultrastructure | Signal Transduction - immunology | Cytoplasmic Granules - metabolism | Peptide Fragments - immunology | src-Family Kinases - metabolism | Female | Receptors, Antigen, T-Cell - immunology | Phosphorylation - immunology | T-Lymphocytes, Cytotoxic - immunology | Cell Polarity - immunology | Microscopy, Electron, Transmission | Immunological Synapses - ultrastructure | Centrosome - immunology | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | Cell Degranulation - immunology | src-Family Kinases - immunology | Centrosome - metabolism | Animals | Cytoplasmic Granules - ultrastructure | T-Lymphocytes, Cytotoxic - metabolism | Immunological Synapses - immunology | Mice | Cytotoxicity, Immunologic - immunology | Cytoplasmic Granules - immunology | T-Lymphocytes, Cytotoxic - ultrastructure | T cells | Machinery | Magneto-electric machines | Scholarships & fellowships | Statistical analysis | Peptides | Cytokines | Microscopy | Cytotoxicity | Ligands | T cell receptors | Kinases | Variance analysis | Apoptosis | Index Medicus
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8. Full Text A novel druglike spleen tyrosine kinase binder prevents anaphylactic shock when administered orally
by Mazuc, Elsa, MSc and Villoutreix, Bruno O., PhD and Malbec, Odile, MSc and Roumier, Thomas, PhD and Fleury, Sébastien and Leonetti, Jean-Paul, PhD and Dombrowicz, David, PhD and Daëron, Marc, MD, PhD and Martineau, Pierre, PhD and Dariavach, Piona, PhD
Journal of allergy and clinical immunology, ISSN 0091-6749, 2008, Volume 122, Issue 1, pp. 188 - 194.e3
Allergy and Immunology | mast cells/basophils | Syk | Allergy and inflammation | tyrosine kinase | anaphylactic shock | degranulation | druglike compound | Allergy | Immunology | Life Sciences & Biomedicine | Science & Technology | Fundamental and applied biological sciences. Psychology | Fundamental immunology | Immunopathology | Biological and medical sciences | Medical sciences | Sarcoidosis. Granulomatous diseases of unproved etiology. Connective tissue diseases. Elastic tissue diseases. Vasculitis | Thiazoles - metabolism | Calcium - metabolism | Protein-Tyrosine Kinases - metabolism | Anaphylaxis - prevention & control | Intracellular Signaling Peptides and Proteins - immunology | Thiazoles - administration & dosage | Intracellular Signaling Peptides and Proteins - metabolism | Thiazoles - therapeutic use | Protein-Tyrosine Kinases - immunology | Mast Cells - metabolism | Protein-Tyrosine Kinases - chemistry | src-Family Kinases - metabolism | Anaphylaxis - immunology | Female | Receptors, IgE - immunology | Syk Kinase | Antibodies, Monoclonal - immunology | Mast Cells - immunology | Cell Degranulation | Signal Transduction | Administration, Oral | Passive Cutaneous Anaphylaxis - immunology | Animals | Proto-Oncogene Proteins c-fyn - metabolism | Intracellular Signaling Peptides and Proteins - chemistry | Thiazoles - chemistry | Mice | Mice, Inbred BALB C | Enzyme Activation | Mitogen-Activated Protein Kinases - metabolism | Prevention | Tyrosine | Phenols | Anaphylaxis | Spleen | Mutagenesis | Cell cycle | Bone marrow | Kinases | Adapter proteins | Binding sites | Index Medicus | Abridged Index Medicus | Mitogen-Activated Protein Kinases | src-Family Kinases | Calcium | Proto-Oncogene Proteins c-fyn | Intracellular Signaling Peptides and Proteins | Antibodies, Monoclonal | Life Sciences | Passive Cutaneous Anaphylaxis | Receptors, IgE | Thiazoles | Protein-Tyrosine Kinases | Pharmaceutical sciences | Mast Cells
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