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Journal of Immunology, ISSN 0022-1767, 02/2014, Volume 192, Issue 3, pp. 919 - 928
The Lyn tyrosine kinase regulates inhibitory signaling in B and myeloid cells: loss of Lyn results in a lupus-like autoimmune disease with hyperactive B cells... 
SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | PROTEIN | DENDRITIC CELLS | DISEASE | GERMINAL CENTER | DEFICIENT MICE | IMMUNOLOGY | MATURATION | AUTOANTIBODY PRODUCTION | T-CELLS | T-Lymphocyte Subsets - immunology | Antibody Specificity | Antibodies, Antinuclear - biosynthesis | Myeloproliferative Disorders - enzymology | Immune Complex Diseases - immunology | Spleen - immunology | Kidney - pathology | Antibodies, Antinuclear - immunology | Cell Count | Germinal Center - immunology | Kidney - immunology | Homeostasis | Myeloproliferative Disorders - immunology | Immunoglobulin M - immunology | Myeloproliferative Disorders - genetics | src-Family Kinases - deficiency | Lupus Nephritis - etiology | Immunoglobulin G - biosynthesis | Autoimmunity - immunology | Immunoglobulin G - immunology | Myeloid Differentiation Factor 88 - immunology | Calcium Signaling - immunology | Spleen - pathology | Immunoglobulin Class Switching | Disease Models, Animal | B-Lymphocytes - enzymology | Lymphocyte Activation | Mice, Inbred C57BL | Mice, Transgenic | Lupus Nephritis - immunology | Germinal Center - pathology | Organ Specificity | src-Family Kinases - immunology | Immune Complex Diseases - pathology | Antibodies, Antinuclear - genetics | Lupus Nephritis - enzymology | Animals | B-Lymphocytes - immunology | Myeloid Differentiation Factor 88 - deficiency | Lymphopoiesis - immunology | Mice | src-Family Kinases - genetics | Immunoglobulin M - biosynthesis | Plasma Cells - immunology
Journal Article
Nature Immunology, ISSN 1529-2908, 08/2010, Volume 11, Issue 8, pp. 734 - 742
Journal Article
Journal of Immunology, ISSN 0022-1767, 08/2014, Volume 193, Issue 4, pp. 1954 - 1965
Canonical neutrophil antimicrobial effector mechanisms, such as degranulation, production of reactive oxygen species, and release of neutrophil extracellular... 
MAMMALIAN TARGET | NADPH OXIDASE | NETTING NEUTROPHILS | SIGNALING PATHWAYS | RESPIRATORY BURST | SYNOVIAL-FLUID | SUPEROXIDE-PRODUCTION | IN-VIVO | IMMUNOLOGY | RECEPTOR-III | CELL-DEATH | Reactive Oxygen Species - metabolism | Nitriles - pharmacology | Humans | Extracellular Signal-Regulated MAP Kinases - antagonists & inhibitors | Intracellular Signaling Peptides and Proteins - immunology | Macrophage-1 Antigen - immunology | Phosphatidylinositol 3-Kinases - antagonists & inhibitors | Receptors, IgG - antagonists & inhibitors | Protein-Tyrosine Kinases - immunology | Lymphocyte Function-Associated Antigen-1 - immunology | Macrophage-1 Antigen - metabolism | Syk Kinase | CD11a Antigen - metabolism | Butadienes - pharmacology | Neutrophil Activation - immunology | GPI-Linked Proteins - immunology | Cell Degranulation | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | src-Family Kinases - antagonists & inhibitors | Autoimmune Diseases - immunology | Cells, Cultured | Neutrophils - immunology | Imidazoles - pharmacology | Inflammation - immunology | Antioxidants - pharmacology | Onium Compounds - pharmacology | Pyrimidines - pharmacology | Receptors, IgG - immunology | src-Family Kinases - immunology | CD18 Antigens - metabolism | Mesalamine - pharmacology | p38 Mitogen-Activated Protein Kinases - antagonists & inhibitors | Aminopyrine - pharmacology | Ascorbic Acid - pharmacology | Pyridines - pharmacology | Antigen-Antibody Complex - immunology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Protein-Tyrosine Kinases - antagonists & inhibitors
Journal Article
Nature Immunology, ISSN 1529-2908, 06/2012, Volume 13, Issue 6, pp. 612 - 620
Journal Article
Immunity, ISSN 1074-7613, 10/2009, Volume 31, Issue 4, pp. 621 - 631
Killing by cytotoxic T lymphocytes (CTLs) is mediated by the secretion of lytic granules. The centrosome plays a key role in granule delivery, polarizing to... 
MOLIMMUNO | CELLIMMUNO | ACTIVATION | TCR | POSITIVE SELECTION | CYTOSKELETON | PHOSPHORYLATION | MICROTUBULE-ORGANIZING CENTER | CTL | IMMUNOLOGY | ANTIGEN RECEPTOR | ALTERED PEPTIDE LIGANDS | SECRETORY LYSOSOMES | Ovalbumin - immunology | Extracellular Signal-Regulated MAP Kinases - metabolism | Immunological Synapses - metabolism | Extracellular Signal-Regulated MAP Kinases - immunology | Centrosome - ultrastructure | Signal Transduction - immunology | Cytoplasmic Granules - metabolism | Peptide Fragments - immunology | src-Family Kinases - metabolism | Female | Receptors, Antigen, T-Cell - immunology | Phosphorylation - immunology | T-Lymphocytes, Cytotoxic - immunology | Cell Polarity - immunology | Microscopy, Electron, Transmission | Immunological Synapses - ultrastructure | Centrosome - immunology | Receptors, Antigen, T-Cell - metabolism | Mice, Inbred C57BL | Cell Degranulation - immunology | src-Family Kinases - immunology | Centrosome - metabolism | Animals | Cytoplasmic Granules - ultrastructure | T-Lymphocytes, Cytotoxic - metabolism | Immunological Synapses - immunology | Mice | Cytotoxicity, Immunologic - immunology | Cytoplasmic Granules - immunology | T-Lymphocytes, Cytotoxic - ultrastructure | T cells | Machinery | Magneto-electric machines | Scholarships & fellowships | Statistical analysis | Peptides | Cytokines | Microscopy | Cytotoxicity | Ligands | T cell receptors | Kinases | Variance analysis | Apoptosis
Journal Article
Current Molecular Medicine, ISSN 1566-5240, 2009, Volume 9, Issue 1, pp. 69 - 85
The activity of tyrosine kinases is central to many cellular processes, and accumulating evidence suggests that their role in inflammation is no less profound.... 
Tyrosine kinases | Inflammation | Cytokines | Rheumatoid Arthritis | Macrophages | MEDICINE, RESEARCH & EXPERIMENTAL | COLLAGEN-INDUCED ARTHRITIS | X-LINKED AGAMMAGLOBULINEMIA | INNATE IMMUNE-RESPONSE | SRC-FAMILY KINASES | TNF-ALPHA PRODUCTION | RECEPTOR-MEDIATED PHAGOCYTOSIS | macrophages | TUMOR-NECROSIS-FACTOR | AFFINITY IGE RECEPTOR | cytokines | NF-KAPPA-B | PATTERN-RECOGNITION RECEPTORS | Protein-Tyrosine Kinases - metabolism | Humans | Intracellular Signaling Peptides and Proteins - immunology | Intracellular Signaling Peptides and Proteins - metabolism | Janus Kinases - metabolism | Proto-Oncogene Proteins c-hck - immunology | Protein-Tyrosine Kinases - immunology | Cell Movement - immunology | Signal Transduction - immunology | Focal Adhesion Kinase 2 - metabolism | Adjuvants, Immunologic - metabolism | Gene Expression - immunology | Protein-Tyrosine Kinases - chemistry | src-Family Kinases - metabolism | Janus Kinases - immunology | Antigen-Antibody Complex - metabolism | Toll-Like Receptors - metabolism | Syk Kinase | Cytokines - immunology | Janus Kinases - chemistry | Cytokines - metabolism | Toll-Like Receptors - immunology | Proto-Oncogene Proteins c-hck - metabolism | Inflammation - immunology | src-Family Kinases - immunology | Animals | Intracellular Signaling Peptides and Proteins - chemistry | Focal Adhesion Kinase 2 - chemistry | Mice | Antigen-Antibody Complex - immunology | src-Family Kinases - chemistry | Chronic Disease | Cytokines - biosynthesis | Focal Adhesion Kinase 2 - immunology
Journal Article
Immunity, ISSN 1074-7613, 03/2013, Volume 38, Issue 3, pp. 489 - 501
The mouse has long served as a paradigm for complex autoimmune and inflammatory disease. Null mutations in which encodes the nonreceptor protein-tyrosine... 
SIGNAL-TRANSDUCTION | VIABLE MOTHEATEN | MACROPHAGES | KINASE | DISEASE | IMMUNOLOGY | SHP-1 | PROTEIN-TYROSINE-PHOSPHATASE | SYSTEMIC AUTOIMMUNITY | T-CELLS | DEFICIENCY | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - immunology | Calgranulin A - metabolism | Protein-Tyrosine Kinases - metabolism | Dendritic Cells - immunology | Humans | Autoimmunity - genetics | Immunoblotting | Intracellular Signaling Peptides and Proteins - immunology | Male | Intracellular Signaling Peptides and Proteins - metabolism | Calgranulin A - genetics | Mice, 129 Strain | CD11c Antigen - immunology | Protein-Tyrosine Kinases - immunology | CD11c Antigen - metabolism | Inflammation - metabolism | CD11c Antigen - genetics | Flow Cytometry | Autoimmunity - immunology | Myeloid Differentiation Factor 88 - immunology | src-Family Kinases - metabolism | Female | Calgranulin A - immunology | Neutrophils - metabolism | Syk Kinase | Dendritic Cells - metabolism | Dermis - metabolism | Mice, Inbred C57BL | Cells, Cultured | Myeloid Differentiation Factor 88 - genetics | Neutrophils - immunology | Mice, Transgenic | Inflammation - immunology | src-Family Kinases - immunology | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - genetics | Dermis - immunology | Mice, Knockout | Animals | Protein Tyrosine Phosphatase, Non-Receptor Type 6 - metabolism | Cell Line, Tumor | Inflammation - genetics | Dermis - pathology | Mice | Mutation | Myeloid Differentiation Factor 88 - metabolism | Autoimmunity | Dendritic cells | Analysis | Skin diseases | Inflammation | Phosphotransferases | Integrins
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2017, Volume 127, Issue 10, pp. 3810 - 3826
Journal Article