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PLoS ONE, ISSN 1932-6203, 03/2012, Volume 7, Issue 3, p. e33814
Bisphenol-A (BPA) is one of the most widespread endocrine disrupting chemicals (EDC) used as the base compound in the manufacture of polycarbonate plastics.... 
LEPTIN | SKELETAL-MUSCLE | CELLS | ENDOCRINE DISRUPTORS | MULTIDISCIPLINARY SCIENCES | INSULIN-SECRETION | SENSITIVITY | MECHANISMS | EXPRESSION | ESTROGEN-RECEPTOR | EXPOSURE | Phosphorylation | Benzhydryl Compounds | Phenols - toxicity | Liver - metabolism | Male | Muscle, Skeletal - metabolism | Insulin Receptor Substrate Proteins - metabolism | Insulin - metabolism | Animals | Liver - drug effects | Signal Transduction - drug effects | Estrogens, Non-Steroidal - toxicity | Injections, Subcutaneous | Muscle, Skeletal - drug effects | Glucose - metabolism | Receptor, Insulin - metabolism | Mice | Proto-Oncogene Proteins c-akt - metabolism | Energy Metabolism - drug effects | Mitogen-Activated Protein Kinases - metabolism | Tyrosine | Type 2 diabetes | Bisphenol-A | Liver | Muscles | Glucose | Insulin | Risk factors | Dextrose | Epoxy resins | Analysis | Polycarbonates | Physiological aspects | Insulin resistance | Mitogens | Protein kinases | Endocrine disruptors | Energy metabolism | Homeostasis | AKT protein | Signal transduction | Rodents | Animal tissues | Polymers | Polycarbonate | Locomotor activity | Body temperature | Abnormalities | Diabetes mellitus | MAP kinase | Metabolism | Resistance factors | Skeletal muscle | Energy balance | Bisphenol A | Signaling | Insulin receptor substrate 1 | Protein kinase | Food intake | Phenols | Calorimetry
Journal Article
FASEB JOURNAL, ISSN 0892-6638, 06/2009, Volume 23, Issue 6, pp. 1946 - 1957
Omega-3-polyunsaturated fatty acids (omega 3-PUFAs) have well-documented protective effects that are attributed not only to eicosanoid inhibition but also to... 
adiponectin | BIOCHEMISTRY & MOLECULAR BIOLOGY | adipose tissue | MICE LACKING ADIPONECTIN | TANDEM MASS-SPECTROMETRY | LIVER-DISEASE | fatty liver disease | CELL BIOLOGY | lipid mediators | GAMMA AGONISTS | DOCOSAHEXAENOIC ACID | BIOLOGY | POLYUNSATURATED FATTY-ACIDS | PPAR-GAMMA | TNF-ALPHA | ADIPOSE-TISSUE | Dietary Fats - metabolism | AMP-Activated Protein Kinases - metabolism | Resistin - genetics | Glucose Transporter Type 4 - metabolism | Fatty Liver - pathology | Hypoglycemic Agents - metabolism | Eicosapentaenoic Acid - analogs & derivatives | Fatty Acids, Omega-3 - chemistry | Adipose Tissue - cytology | Male | Muscle, Skeletal - metabolism | Insulin Receptor Substrate Proteins - metabolism | PPAR gamma - metabolism | Adipose Tissue - metabolism | Adiponectin - genetics | Adiponectin - metabolism | Chemokine CCL2 - metabolism | Insulin Receptor Substrate Proteins - genetics | PPAR gamma - genetics | Fatty Liver - diet therapy | Resistin - metabolism | Fatty Acids, Omega-3 - metabolism | Fatty Liver - metabolism | Glucose Transporter Type 4 - genetics | Eicosapentaenoic Acid - metabolism | Insulin Resistance | Chemokine CCL2 - genetics | Thiazolidinediones - metabolism | Obesity - metabolism | Obesity - pathology | Animals | Diet | Fatty Acids, Omega-3 - therapeutic use | Mice, Obese | Mice | Docosahexaenoic Acids - metabolism
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2018, Volume 13, Issue 7, p. e0200847
To investigate the role of miR-122 in the development and regression of non-alcoholic fatty liver disease (NAFLD) in vitro, we used multicellular 3D human... 
OVEREXPRESSION | HOMEOSTASIS | LIPID-METABOLISM | MULTIDISCIPLINARY SCIENCES | DISEASE | SENSITIVITY | SYSTEMS | LIPOPROTEIN-LIPASE | Glucose Transporter Type 4 - metabolism | Signal Transduction | Humans | Liver - metabolism | Organoids - cytology | MicroRNAs - metabolism | Necrosis - metabolism | Non-alcoholic Fatty Liver Disease - metabolism | Hepatocytes - metabolism | Insulin Receptor Substrate Proteins - metabolism | Inflammation - metabolism | Insulin - metabolism | Matrix Metalloproteinase 9 - metabolism | Matrix Metalloproteinase 8 - metabolism | Organoids - metabolism | Chemokine CCL3 - metabolism | Chemokine CCL2 - metabolism | Kupffer Cells - metabolism | Liver - cytology | Interleukin-6 - metabolism | Care and treatment | MicroRNA | Liver diseases | Development and progression | Insulin resistance | Inflammation | Research | Laboratories | Liver | Kupffer cells | Fluorescence | Reversing | Lipids | Necrosis | Interleukin 6 | Liver cancer | Fatty liver | Organoids | Rodents | Gastroenterology | Drug metabolism | Lipoprotein (low density) receptors | Inhibition | Lipid metabolism | Stellate cells | Cytokines | Incubation | Internal medicine | CCL3 protein | Regression analysis | Gene expression | Metabolism | Ribonucleic acid--RNA | Insulin | Patients | Fatty acids | Endothelial cells | Gelatinase B | Steatosis | Medicine | Urea | Signaling | Hepatocytes | Tumor necrosis factor | Pharmacy | Fibrosis | Neutrophil collagenase | Diabetes | Chemokines | Monocyte chemoattractant protein 1 | Metabolic disorders | RNA | Ribonucleic acid
Journal Article
Science, ISSN 0036-8075, 10/2004, Volume 306, Issue 5695, pp. 457 - 461
Obesity contributes to the development of type 2 diabetes, but the underlying mechanisms are poorly understood. Using cell culture and mouse models, we show... 
Obesity | Phosphorylation | Receptors | Quantification | Liver | Lead | Insulin resistance | Type 2 diabetes mellitus | Insulin | Research Article | Type 1 diabetes mellitus | UNFOLDED PROTEIN RESPONSE | MESSENGER-RNA | ER STRESS | JNK | MULTIDISCIPLINARY SCIENCES | KINASE | IRE1 | RESISTANCE | TRANSCRIPTION FACTOR | XBP-1 | TRANSLATIONAL CONTROL | eIF-2 Kinase - metabolism | Endoplasmic Reticulum - metabolism | Homeostasis | Muscle, Skeletal - metabolism | Diabetes Mellitus, Type 2 - metabolism | Phosphoproteins - metabolism | X-Box Binding Protein 1 | DNA-Binding Proteins - metabolism | Adipose Tissue - metabolism | Insulin Receptor Substrate Proteins | Membrane Proteins - metabolism | Nuclear Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Signal Transduction | Liver - metabolism | Cells, Cultured | Insulin Resistance | Rats | Nuclear Proteins - metabolism | DNA-Binding Proteins - genetics | Regulatory Factor X Transcription Factors | Obesity - metabolism | Insulin - metabolism | Animals | Mitogen-Activated Protein Kinase 8 | Tunicamycin - pharmacology | Glucose - metabolism | Mice, Obese | Receptor, Insulin - metabolism | Mice | Mice, Inbred BALB C | Transcription Factors | Mutation | Mitogen-Activated Protein Kinases - metabolism | Type 2 diabetes | Causes of | Stress (Physiology) | Research | Endoplasmic reticulum | Cell culture | Enzymes | Medical research | Diabetes
Journal Article
Nature, ISSN 0028-0836, 2014, Volume 505, Issue 7484, pp. 564 - 568
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2015, Volume 10, Issue 8, p. e0136822
Methionine metabolism plays a central role in methylation reactions, production of glutathione and methylarginines, and modulating homocysteine levels. The... 
AMINO-ACID-METABOLISM | OXIDATIVE STRESS | DNA METHYLATION | LIQUID-CHROMATOGRAPHY | NITRIC-OXIDE SYNTHASE | INSULIN-RESISTANCE | MULTIDISCIPLINARY SCIENCES | FOLLOW-UP | STEATOHEPATITIS | ONE-CARBON METABOLISM | MASS-SPECTROMETRY | Glycine N-Methyltransferase - metabolism | Blood Chemical Analysis | Homocysteine - metabolism | Glutathione - biosynthesis | Diet, High-Fat | Female | Metabolic Networks and Pathways - physiology | Cysteine - metabolism | Dipeptides - metabolism | Betaine-Homocysteine S-Methyltransferase - metabolism | Acyl Coenzyme A - metabolism | B-Lymphocytes - metabolism | Methionine - metabolism | Liver - metabolism | Mice, Inbred C57BL | Metabolome | Adenosylhomocysteinase - metabolism | Methionine Adenosyltransferase - metabolism | DNA Methylation - genetics | Non-alcoholic Fatty Liver Disease - metabolism | Cystathionine beta-Synthase - metabolism | Random Allocation | Animals | 5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase - metabolism | Mice | Fatty liver | Physiological aspects | Development and progression | Genetic aspects | Research | Homocysteine | Amino acid metabolism | Transcription factors | Adenosylmethionine | High cholesterol diet | Bcl-2 protein | Laboratories | Liver | Glycine | Caspase-3 | Proteins | Elevation | Arginine | Betaine | Rodents | DNA methylation | Deoxyribonucleic acid--DNA | Glutathione | Phosphatidylethanolamine | Liver diseases | Nutrition | 5-Methyltetrahydrofolate-homocysteine S-methyltransferase | Methionine | Glycine N-methyltransferase | c-Jun protein | Caspase | Betaine-homocysteine S-methyltransferase | Gene expression | Metabolism | Fatty acids | Lymphoma | Fatty-acid synthase | Cholesterol | Molecular chains | Substrates | Depletion | Lymphocytes B | Diet | Nitric oxide | Fibrosis | DNA methyltransferase | Methylation | Nuclear reactions | Polymethyl methacrylate | B-cell lymphoma | Deoxyribonucleic acid | DNA
Journal Article
Plant Cell, ISSN 1040-4651, 12/2017, Volume 29, Issue 12, pp. 3234 - 3254
Methylglyoxal (MGO) and glyoxal (GO) are toxic reactive carbonyl species generated as by-products of glycolysis. The pre-emption pathway for detoxification of... 
ARABIDOPSIS-THALIANA | PROTEIN | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | GLYCATION | D-LACTATE DEHYDROGENASE | PLANT SCIENCES | CELL BIOLOGY | SUBSTRATE-SPECIFICITY | ENCODING GENES | GENOME-WIDE ANALYSIS | METHYLGLYOXAL | GLYOXALASE-I | Inactivation, Metabolic | Arabidopsis - enzymology | Glutathione - metabolism | Eukaryotic Cells - metabolism | RNA, Messenger - metabolism | Arabidopsis Proteins - metabolism | Saccharomyces cerevisiae - metabolism | Protoplasts - metabolism | Pyruvaldehyde - metabolism | Isoenzymes - metabolism | Gene Expression Regulation, Plant | Free Radicals - metabolism | Plant Cells - metabolism | Lactoylglutathione Lyase - metabolism | Stress, Physiological - genetics | Alternative Splicing - genetics | Arabidopsis - cytology | RNA, Messenger - genetics | Mutation - genetics | Subcellular Fractions - metabolism | Chloroplasts - metabolism | Arabidopsis - metabolism | Arabidopsis - genetics | Metals - metabolism | Plant Leaves - metabolism | Models, Biological | Cytosol - metabolism | Sugars - metabolism | Arabidopsis thaliana | Glucose metabolism | Defense industry | Germination | Glutamine | Alternative splicing | Yeast | Transcription | Splicing | Detoxification | Byproducts | Chemical reactions | Homology | Cytosol | Seedlings | Mitochondria | Developmental stages | Chloroplasts | Coding | Compartments | Isoforms | Glycolysis | Biocompatibility | Lactoylglutathione lyase | Pyruvaldehyde | Species | Sugar | Carbonyls | Index Medicus
Journal Article
Nature, ISSN 0028-0836, 10/2017, Volume 550, Issue 7674, pp. 119 - 123
Catecholamine-induced lipolysis, the first step in the generation of energy substrates by the hydrolysis of triglycerides(1), declines with age(2,3). The... 
MONOAMINE-OXIDASE | CELLS | OBESITY | ACTIVATION | MULTIDISCIPLINARY SCIENCES | ACCUMULATION | IDENTIFICATION | GENE ONTOLOGY | DEFICIENCY | ADIPOSE-TISSUE | AGE | Inflammasomes - metabolism | Lipolysis - drug effects | Catecholamines - metabolism | Growth Differentiation Factor 3 - metabolism | Sterol Esterase - metabolism | Aging - drug effects | Adipose Tissue - cytology | Caspase 1 - metabolism | Gene Expression Profiling | Growth Differentiation Factor 3 - deficiency | Lipolysis - genetics | Adipose Tissue - metabolism | Aging - genetics | Monoamine Oxidase Inhibitors - pharmacology | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Lipase - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - deficiency | Gene Expression Regulation - drug effects | Macrophages - metabolism | Animals | Norepinephrine - metabolism | Growth Differentiation Factor 3 - genetics | Adipocytes - metabolism | Mice | Adipose Tissue - drug effects | Catecholamines - pharmacology | Aging - metabolism | Monoamine Oxidase - metabolism | Aging | Observations | Catecholamine metabolism | Health aspects | Elderly people | Adipose tissue | Oxidase | Genomes | Adipocytes | Kinases | Macrophages | Lipase | Caspase-1 | Reduction | Energy resources | Clonal deletion | Deletion | Noradrenaline | Age | Enzymes | Starvation | Fasting | Body temperature | Aging (artificial) | Glycerol | Caspase | Principal components analysis | Triglycerides | Inflammation | Bioavailability | Metabolism | Gene expression | Sympathetic nervous system | Catecholamine | Fatty acids | Substrates | Lipolysis | Amine oxidase (flavin-containing) | Signaling | Catabolism | Norepinephrine | Elderly | Geriatrics
Journal Article
Journal Article