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Journal Article
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2013, Volume 451, Issue 2, pp. 313 - 328
Journal Article
Arthritis Research and Therapy, ISSN 1478-6354, 10/2013, Volume 15, Issue 5, pp. R146 - R146
Introduction: Spleen tyrosine kinase (SYK) is a key integrator of intracellular signals triggered by activated immunoreceptors, including Bcell receptors (BCR)... 
RHEUMATOID-ARTHRITIS | PATHOGENESIS | SYSTEMIC-LUPUS-ERYTHEMATOSUS | ACTIVATION | TOLL-LIKE RECEPTORS | BTK | NECROSIS-FACTOR-ALPHA | BONE | RHEUMATOLOGY | OSTEOCLAST DIFFERENTIATION | C-SRC | Small Molecule Libraries - pharmacology | Protein-Tyrosine Kinases - metabolism | Small Molecule Libraries - administration & dosage | Humans | Intracellular Signaling Peptides and Proteins - metabolism | Pyridazines - pharmacology | Osteoclasts - cytology | Arthritis, Experimental - metabolism | Aminopyridines - chemistry | Protein Kinase Inhibitors - chemistry | Flow Cytometry | Arthritis, Experimental - prevention & control | Protein-Tyrosine Kinases - chemistry | Mice, Inbred DBA | Molecular Structure | Autoimmune Diseases - metabolism | Syk Kinase | Autoimmune Diseases - drug therapy | B-Lymphocytes - metabolism | Protein Structure, Tertiary | Immunity, Innate - drug effects | Administration, Oral | Jurkat Cells | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Mice, Inbred C57BL | Cells, Cultured | Models, Molecular | Macrophages - cytology | Osteoclasts - metabolism | Pyridazines - chemistry | B-Lymphocytes - drug effects | Protein Kinase Inhibitors - administration & dosage | Small Molecule Libraries - chemistry | Macrophages - metabolism | Adaptive Immunity - drug effects | Animals | B-Lymphocytes - immunology | Signal Transduction - drug effects | Intracellular Signaling Peptides and Proteins - chemistry | Aminopyridines - pharmacology | Cell Line, Tumor | Protein Binding | Macrophages - drug effects | Mice | Protein Kinase Inhibitors - pharmacology | Osteoclasts - drug effects | Protein-Tyrosine Kinases - antagonists & inhibitors | Multiple sclerosis | Immune response | Dendritic cells | Immunoglobulin G | Arthritis | B cells | Cell differentiation | Immunity | Proteins | Collagen | Antiarthritic agents | Pharmaceutical industry | Drug therapy | Health aspects | Index Medicus
Journal Article
Rheumatology (United Kingdom), ISSN 1462-0324, 11/2014, Volume 54, Issue 1, pp. 169 - 177
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 11/2014, Volume 124, Issue 11, pp. 5074 - 5084
Patients with BRAFV(600E/K)-driven melanoma respond to the BRAF inhibitor vemurafenib due to subsequent deactivation of the proliferative RAS/RAF/MEK/ERK... 
DABRAFENIB | TRIAL | MEDICINE, RESEARCH & EXPERIMENTAL | METASTATIC MELANOMA | MEK INHIBITION | NON-HODGKIN-LYMPHOMA | RAF INHIBITORS | IMPROVED SURVIVAL | OPEN-LABEL | PROLIFERATION | B-RAF | Phosphorylation | Cell Proliferation | Skin Neoplasms - drug therapy | Protein-Tyrosine Kinases - metabolism | Humans | Middle Aged | Antineoplastic Agents - therapeutic use | Intracellular Signaling Peptides and Proteins - metabolism | Extracellular Signal-Regulated MAP Kinases - metabolism | Mutation, Missense | Leukemia, Lymphocytic, Chronic, B-Cell - chemically induced | MAP Kinase Signaling System | Leukemia, Lymphocytic, Chronic, B-Cell - diagnostic imaging | Antineoplastic Agents - adverse effects | Melanoma - genetics | Syk Kinase | Cell Survival - drug effects | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Treatment Outcome | Proto-Oncogene Proteins B-raf - antagonists & inhibitors | Indoles - adverse effects | Sulfonamides - therapeutic use | Proto-Oncogene Proteins B-raf - genetics | Melanoma - drug therapy | Skin Neoplasms - genetics | Radionuclide Imaging | Cell Line, Tumor | Sulfonamides - adverse effects | Indoles - therapeutic use | Protein Processing, Post-Translational | Protein-Tyrosine Kinases - antagonists & inhibitors | Vemurafenib | Chronic lymphocytic leukemia | Physiological aspects | Development and progression | Research | Protein kinases | Health aspects | Lymphocytes | Biopsy | Medical prognosis | Melanoma | Genomes | Mutation | Metastasis | Kinases | Patients | Index Medicus | Abridged Index Medicus
Journal Article
Leukemia, ISSN 0887-6924, 2012, Volume 26, Issue 7, pp. 1576 - 1583
Journal Article
Clinical Cancer Research, ISSN 1078-0432, 05/2017, Volume 23, Issue 9, pp. 2313 - 2324
Purpose: B-cell receptor (BCR)-associated kinase inhibitors, such as ibrutinib, have revolutionized the treatment of chronic lymphocytic leukemia (CLL).... 
SURFACE IGM | APOPTOSIS | CLL | ACTIVATION | TREATMENT-NAIVE | ONCOLOGY | IDELALISIB | RESISTANCE | IBRUTINIB | TYROSINE KINASE INHIBITOR | EXPRESSION | Receptors, Antigen, B-Cell - drug effects | Tumor Microenvironment - drug effects | Antineoplastic Combined Chemotherapy Protocols - administration & dosage | Leukocytes, Mononuclear - drug effects | Apoptosis - drug effects | Pyrimidines - administration & dosage | Humans | Bridged Bicyclo Compounds, Heterocyclic - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - genetics | Syk Kinase - antagonists & inhibitors | Leukemia, Lymphocytic, Chronic, B-Cell - pathology | Janus Kinases - antagonists & inhibitors | B-Lymphocytes - drug effects | Pyrazoles - administration & dosage | Flow Cytometry | Janus Kinase Inhibitors - administration & dosage | Signal Transduction - drug effects | Proto-Oncogene Proteins c-bcr - genetics | Gene Expression Regulation, Neoplastic - drug effects | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Proto-Oncogene Proteins c-bcr - antagonists & inhibitors | Neoplasm Proteins - genetics | Sulfonamides - administration & dosage | Sulfones - administration & dosage | BCR protein | Immunoglobulin M | Flow cytometry | Bcl-2 protein | Leukemia | Carbon tetrachloride | Medical services | Clinical trials | Immunoblotting | ZAP-70 protein | B-cell receptor | CD40L protein | Lymph nodes | Signal transduction | Interleukin 4 | Bcl-x protein | Pathways | Enzyme-linked immunosorbent assay | Medical research | Chronic lymphatic leukemia | CD49d antigen | CCL3 protein | Lymphatic leukemia | CCL4 protein | Patients | Mcl-1 protein | Cytometry | Signaling | Inhibitors | Lymphocytes B | Experimental design | Cell death | Syk protein | Cancer | Apoptosis | Index Medicus | Cerdulatinib | STAT6 | JAK3
Journal Article
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 12/2016, Volume 26, Issue 24, pp. 5947 - 5950
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 01/2017, Volume 118, Issue 1, pp. 191 - 203
Journal Article
Blood, ISSN 0006-4971, 04/2010, Volume 115, Issue 13, pp. 2578 - 2585
Certain malignant B cells rely on B-cell receptor (BCR)-mediated survival signals. Spleen tyrosine kinase (Syk) initiates and amplifies the BCR signal. In in... 
RHEUMATOID-ARTHRITIS | BCR | B-CELL LYMPHOMA | RESPONSE CRITERIA | R-CHOP | THERAPEUTIC TARGET | PHASE-III | TYROSINE KINASE INHIBITOR | FOLLICULAR LYMPHOMA | HEMATOLOGY | EXPRESSION | Humans | Middle Aged | Neoplasm Proteins - physiology | Salvage Therapy | Male | Neoplasm Proteins - antagonists & inhibitors | Antineoplastic Agents - therapeutic use | Lymphoma, Non-Hodgkin - enzymology | Antineoplastic Agents - administration & dosage | Protein Kinase Inhibitors - adverse effects | Diarrhea - chemically induced | Protein-Tyrosine Kinases - physiology | Pyridines - adverse effects | Antineoplastic Agents - adverse effects | Hypertension - chemically induced | Aged, 80 and over | Adult | Female | Antineoplastic Agents - pharmacology | Oxazines - administration & dosage | Syk Kinase | Lymphoma, Non-Hodgkin - drug therapy | Oxazines - pharmacology | Pyridines - therapeutic use | Hematologic Diseases - chemically induced | Pyridines - administration & dosage | Intracellular Signaling Peptides and Proteins - antagonists & inhibitors | Treatment Outcome | Oxazines - adverse effects | Disease-Free Survival | Protein Kinase Inhibitors - administration & dosage | Leukemia, Lymphocytic, Chronic, B-Cell - enzymology | Oxazines - therapeutic use | Protein Kinase Inhibitors - therapeutic use | Aged | Protein Kinase Inhibitors - pharmacology | Pyridines - pharmacology | Leukemia, Lymphocytic, Chronic, B-Cell - drug therapy | Intracellular Signaling Peptides and Proteins - physiology | Cohort Studies | Protein-Tyrosine Kinases - antagonists & inhibitors | Index Medicus | Abridged Index Medicus | Clinical Trials and Observations
Journal Article
Journal Article