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1. Full Text Compensatory anti-inflammatory response syndrome
by Minou Adib-Conquy and Jean-Marc Cavaillon
Thrombosis and Haemostasis, ISSN 0340-6245, 01/2009, Volume 101, Issue 1, pp. 36 - 47
Summary The concept of ‘Compensatory anti-inflammatory response syndrome’ (CARS) was proposed in 1997 by Roger Bone (1941–1997) to qualify the consequences of... 
cytokine | infection | two-hit model | monocyte | immunity | Endotoxin | neutrophil | Review Article | Infection | Neutrophil | Monocyte | Immunity | Cytokine | INVITRO CYTOKINE PRODUCTION | MESSENGER-RNA EXPRESSION | HUMAN SEPTIC SHOCK | LEUKOCYTE ANTIGEN-DR | ELEMENT-BINDING PROTEIN | BLOOD MONONUCLEAR-CELLS | RESPIRATORY-DISTRESS-SYNDROME | TUMOR-NECROSIS-FACTOR | DISSEMINATED INTRAVASCULAR COAGULATION | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | NF-KAPPA-B | endotoxin | Leukocytes - pathology | Sepsis - immunology | Sepsis - prevention & control | Humans | Gene Expression Regulation | Inflammation Mediators - blood | Neutrophils - immunology | Monocytes - immunology | Systemic Inflammatory Response Syndrome - genetics | Sepsis - genetics | Leukocytes - immunology | Adaptation, Physiological - immunology | Systemic Inflammatory Response Syndrome - pathology | Animals | Lymphocytes - immunology | Sepsis - pathology | Endotoxins - immunology | Systemic Inflammatory Response Syndrome - immunology | Systemic Inflammatory Response Syndrome - prevention & control | Apoptosis | Disease Models, Animal
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2. Full Text Systemic Inflammatory Response Syndrome Criteria in Defining Severe Sepsis
by Kaukonen, Kirsi-Maija and Bailey, Michael and Pilcher, David and Cooper, D. Jamie and Bellomo, Rinaldo
The New England Journal of Medicine, ISSN 0028-4793, 04/2015, Volume 372, Issue 17, pp. 1629 - 1638
Sepsis remains a major global cause of morbidity and death. This investigation from Australia and New Zealand ICUs challenges the utility of the two criteria... 
MORTALITY | SIRS | MEDICINE, GENERAL & INTERNAL | THERAPY | ADULTS | NEW-ZEALAND RISK | TIME | GOAL-DIRECTED RESUSCITATION | PREDICTION | Severity of Illness Index | Intensive Care Units | Humans | Middle Aged | Sepsis - diagnosis | Male | Sepsis - classification | Sepsis - mortality | Multiple Organ Failure | New Zealand | Sensitivity and Specificity | Female | Organ Dysfunction Scores | Aged | Retrospective Studies | Australia | Odds Ratio | Systemic Inflammatory Response Syndrome - classification | Systemic Inflammatory Response Syndrome - diagnosis | Systemic Inflammatory Response Syndrome - mortality | Databases, Factual | Intensive care units | Validity | Intensive care | Mortality | Sepsis | Infections | Inflammation | Inflammatory diseases | Validation studies
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3. Full Text The Fetal Inflammatory Response Syndrome
by GOTSCH, FRANCESCA and ROMERO, ROBERTO and KUSANOVIC, JUAN PEDRO and MAZAKI-TOVI, SHALI and PINELES, BETH L and EREZ, OFFER and ESPINOZA, JIMMY and HASSAN, SONIA S
Clinical Obstetrics and Gynecology, ISSN 0009-9201, 09/2007, Volume 50, Issue 3, pp. 652 - 683
The fetal inflammatory response syndrome (FIRS) is a condition characterized by systemic inflammation and an elevation of fetal plasma interleukin-6. This... 
Chorioamnionitis | Prematurity | PROM | Premature birth | Preterm labor | Intrauterine infection | Funisitis | prematurity | intrauterine infection | INTERLEUKIN-1 RECEPTOR ANTAGONIST | preterm labor | INDUCED LUNG MATURATION | AMNIOTIC-FLUID | chorioammionitis | WHITE-MATTER INJURY | OBSTETRICS & GYNECOLOGY | funisitis | UMBILICAL-CORD PLASMA | TUMOR-NECROSIS-FACTOR | premature birth | TOLL-LIKE RECEPTORS | REGULATORY T-CELLS | PRETERM PREMATURE RUPTURE | CEREBRAL-PALSY | Fetal Membranes, Premature Rupture - etiology | Systemic Inflammatory Response Syndrome - physiopathology | Humans | Obstetric Labor, Premature - immunology | Organ Specificity - immunology | Pregnancy | Fetal Diseases - physiopathology | Immunity, Innate - immunology | Fetal Membranes, Premature Rupture - immunology | Fetal Diseases - immunology | Systemic Inflammatory Response Syndrome - immunology | Female | Obstetric Labor, Premature - etiology | Chemokines - immunology | Cytokines - immunology
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4. Full Text RIP Kinase-Dependent Necrosis Drives Lethal Systemic Inflammatory Response Syndrome
by Duprez, Linde and Takahashi, Nozomi and Van Hauwermeiren, Filip and Vandendriessche, Benjamin and Goossens, Vera and Vanden Berghe, Tom and Declercq, Wim and Libert, Claude and Cauwels, Anje and Vandenabeele, Peter
Immunity, ISSN 1074-7613, 2011, Volume 35, Issue 6, pp. 908 - 918
Engagement of tumor necrosis factor receptor 1 signals two diametrically opposed pathways: survival-inflammation and cell death. An additional switch decides,... 
APOPTOSIS | SHOCK | ACTIVATION | NECROPTOSIS | CECAL LIGATION | CASPASES | RECEPTOR | SEPSIS | IMMUNOLOGY | TNF | CELL-DEATH | Intestines - drug effects | Receptor-Interacting Protein Serine-Threonine Kinases - metabolism | Apoptosis - drug effects | Imidazoles - administration & dosage | Intestines - metabolism | Systemic Inflammatory Response Syndrome - genetics | Indoles - administration & dosage | Necrosis | Caspases - metabolism | Gene Deletion | Cecal Diseases - pathology | Indoles - pharmacology | Intestines - pathology | Mice, Inbred C57BL | Kaplan-Meier Estimate | Cecal Diseases - genetics | Imidazoles - pharmacology | Mice, Knockout | Tumor Necrosis Factor-alpha - pharmacology | Receptor-Interacting Protein Serine-Threonine Kinases - genetics | Animals | Systemic Inflammatory Response Syndrome - enzymology | Mice | Receptor-Interacting Protein Serine-Threonine Kinases - deficiency | Systemic Inflammatory Response Syndrome - mortality | Cell death | Plasma | Statistical analysis | Histopathology | Body temperature | Sepsis | Kinases | Experiments | Variance analysis | Apoptosis
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5. Full Text Incidence and prognostic value of the systemic inflammatory response syndrome and organ dysfunctions in ward patients
by Churpek, Matthew M and Zadravecz, Frank J and Winslow, Christopher and Howell, Michael D and Edelson, Dana P
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2015, Volume 192, Issue 8, pp. 958 - 964
Rationale: Tools that screen inpatients for sepsis use the systemic inflammatory response syndrome (SIRS) criteria and organ dysfunctions, but most studies of... 
Organ dysfunction scores | Multiple organ failure | Sepsis | Systemic inflammatory response syndrome | MORTALITY | EARLY WARNING SCORE | RISK | multiple organ failure | DEFINITIONS | systemic inflammatory response syndrome | ADMISSION | INTENSIVE-CARE-UNIT | RESPIRATORY SYSTEM | organ dysfunction scores | EARLY SEPTIC SHOCK | INFECTION | sepsis | EPIDEMIOLOGY | SEVERE SEPSIS | CRITICAL CARE MEDICINE | Prognosis | Humans | Middle Aged | Sepsis - diagnosis | Male | Incidence | Multiple Organ Failure - epidemiology | Aged, 80 and over | Adult | Female | Leukocyte Count | Databases, Factual | Patients' Rooms | Length of Stay | Heart Rate | Respiratory Rate | Hospital Mortality | Hospitalization | Body Temperature | Systemic Inflammatory Response Syndrome - epidemiology | Multiple Organ Failure - diagnosis | Mass Screening | Platelet Count | Aged | Systemic Inflammatory Response Syndrome - diagnosis | Original
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6. Full Text Systemic inflammatory response syndrome (SIRS)
: Where did it come from and is it still relevant today?
by Balk, Robert A
Virulence, ISSN 2150-5594, 01/2014, Volume 5, Issue 1, pp. 20 - 26
The concept of a systemic inflammatory response syndrome (SIRS) to describe the complex pathophysiologic response to an insult such as infection, trauma,... 
systemic inflammatory response syndrome (SIRS) | inflammatory response | septic shock | severe sepsis | sepsis | Systemic inflammatory response syndrome (sirs) | Inflammatory response | Sepsis | Septic shock | Severe sepsis | UNITED-STATES | INFECTIOUS DISEASES | MULTICENTER | MANAGEMENT | EFFICACY | SAFETY | MICROBIOLOGY | IMMUNOLOGY | PATHOGENESIS | DEFINITIONS | THERAPIES | Anti-Inflammatory Agents - therapeutic use | Sepsis - diagnosis | Systemic Inflammatory Response Syndrome - diagnosis | Humans | Sepsis - therapy | Systemic Inflammatory Response Syndrome - therapy | Review
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7. Full Text Systemic Inflammatory Response Syndrome, Quick Sequential Organ Function Assessment, and Organ Dysfunction: Insights From a Prospective Database of ED Patients With Infection
by Williams, Julian M and Greenslade, Jaimi H and McKenzie, Juliet V and Chu, Kevin and Brown, Anthony F.T and Lipman, Jeffrey
Chest, ISSN 0012-3692, 03/2017, Volume 151, Issue 3, pp. 586 - 596
Background A proposed revision of sepsis definitions has abandoned the systemic inflammatory response syndrome (SIRS), defined organ dysfunction as an increase... 
SIRS | infection | emergency medicine | qSOFA | organ dysfunction | MORTALITY | CRITERIA | FAILURE | DEFINITIONS | RESPIRATORY SYSTEM | EMERGENCY-DEPARTMENT PATIENTS | ASSOCIATION | SEVERE SEPSIS | CRITICAL CARE MEDICINE | Emergency Service, Hospital | Prognosis | Prospective Studies | Humans | Middle Aged | Mortality | Sepsis - epidemiology | Sepsis - diagnosis | Male | Hospitalization | Systemic Inflammatory Response Syndrome - epidemiology | Multiple Organ Failure - diagnosis | Multiple Organ Failure - epidemiology | Sepsis - mortality | Sensitivity and Specificity | Aged, 80 and over | Adult | Female | Organ Dysfunction Scores | ROC Curve | Aged | Systemic Inflammatory Response Syndrome - diagnosis | Databases, Factual | Infection | Prevention | Multiple organ failure | Sepsis | Research | Risk factors
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8. Full Text Quick sepsis-related organ failure assessment, systemic inflammatory response syndrome, and early warning scores for detecting clinical deterioration in infected patients outside theintensive care unit
by Churpek, Matthew M and Snyder, Ashley and Han, Xuan and Sokol, Sarah and Pettit, Natasha and Howell, Michael D and Edelson, Dana P
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 04/2017, Volume 195, Issue 7, pp. 906 - 911
Sepsis | Early warning scores | Systemic inflammatory response syndrome | QSOFA | Organ dysfunction Scores
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9. Full Text Systemic inflammatory response syndrome
by Davies, M. G and Hagen, P.‐O
British Journal of Surgery, ISSN 0007-1323, 07/1997, Volume 84, Issue 7, pp. 920 - 935
Background Localized inflammation is a physiological protective response which is generally tightly controlled by the body at the site of injury. Loss of this... 
SURGERY | GRAM-NEGATIVE SEPSIS | TUMOR-NECROSIS-FACTOR | NITRIC-OXIDE SYNTHASE | INTERLEUKIN-1 RECEPTOR ANTAGONIST | DISSEMINATED INTRAVASCULAR COAGULATION | MONOCYTE CHEMOATTRACTANT PROTEIN-1 | ACUTE LUNG INJURY | PLATELET-ACTIVATING-FACTOR | ESCHERICHIA-COLI INFECTION | RESPIRATORY-DISTRESS-SYNDROME | Nitric Oxide - biosynthesis | Platelet Activating Factor - metabolism | Arachidonic Acid - metabolism | Reactive Oxygen Species - metabolism | Systemic Inflammatory Response Syndrome - physiopathology | Humans | Systemic Inflammatory Response Syndrome - etiology | Enteral Nutrition | Leukocytes - physiology | Cytokines - physiology | Endothelium - physiopathology | Systemic Inflammatory Response Syndrome - therapy
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10. Full Text The systemic inflammatory response syndrome
by Robertson, Charles M and Coopersmith, Craig M
Microbes and Infection, ISSN 1286-4579, 2006, Volume 8, Issue 5, pp. 1382 - 1389
The systemic inflammatory response syndrome (SIRS) is the body's response to an infectious or noninfectious insult. Although the definition of SIRS refers to... 
Adaptive immune system | Hypoinflammatory | Critical illness | Hyperinflammatory | Systemic inflammatory response syndrome | Pathophysiology | Multiple organ dysfunction syndrome | Biomarkers | Sepsis | Inflammation | Innate immune system | SURVIVAL | hypoinflammatory | DELTA T-LYMPHOCYTES | critical illness | biomarkers | PROCALCITONIN | ACUTE LUNG INJURY | MICROBIOLOGY | adaptive immune system | IMMUNOLOGY | multiple organ dysfunction syndrome | hyperinflammatory | innate immune system | DEFINITIONS | systemic inflammatory response syndrome | MULTIPLE ORGAN DYSFUNCTION | VIROLOGY | inflammation | pathophysiology | SYNDROME SIRS | sepsis | EPITHELIAL APOPTOSIS | INNATE IMMUNITY | Systemic Inflammatory Response Syndrome - physiopathology | Humans | Systemic Inflammatory Response Syndrome - immunology | Systemic Inflammatory Response Syndrome - epidemiology | Systemic Inflammatory Response Syndrome - therapy
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11. Full Text Quick Sepsis-related Organ Failure Assessment; Systemic Inflammatory Response Syndrome, and Early Warning Scores for Detecting Clinical Deterioration in Infected Patients outside the Intensive Care Unit
by Churpek, MM and Snyder, A and Han, X and Sokol, S and Pettit, N and Howell, MD and Edelson, DP
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, ISSN 1073-449X, 04/2017, Volume 195, Issue 7, pp. 906 - 911
Rationale: The 2016 definitions of sepsis included the quick Sepsis related Organ Failure Assessment (qSOFA) score to identify high risk patients outside the... 
CRITERIA | HOSPITALIZED-PATIENTS | INTERNATIONAL CONSENSUS DEFINITIONS | RISK STRATIFICATION | GUIDELINES | VALIDATION | PREDICTION | early warning scores | WARD PATIENTS | systemic inflammatory response syndrome | JUDGMENT | SEPTIC SHOCK SEPSIS-3 | RESPIRATORY SYSTEM | organ dysfunction scores | qSOFA | sepsis | CRITICAL CARE MEDICINE | Emergency Service, Hospital | Reproducibility of Results | Risk Assessment | Humans | Middle Aged | Sepsis - diagnosis | Male | Sepsis - complications | Hospitalization | Sensitivity and Specificity | Female | Organ Dysfunction Scores | ROC Curve | Systemic Inflammatory Response Syndrome - complications | Systemic Inflammatory Response Syndrome - diagnosis | Original
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