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Journal Article
Blood, ISSN 0006-4971, 01/2013, Volume 121, Issue 3, pp. 499 - 509
Journal Article
Haematologica, ISSN 0390-6078, 06/2019, p. haematol.2019.225557
Journal Article
Biomedicine & Pharmacotherapy, ISSN 0753-3322, 09/2019, Volume 117, pp. 109113 - 109113
The fusion gene AML1-ETO initially dysregulates various cell cycle molecules in t(8;21) acute myeloid leukemia. Aurora kinases have shown great promise in... 
Aurora kinase | Barasertib | Alisertib | AML-ETO | Acute myeloid leukemia | AML | MEDICINE, RESEARCH & EXPERIMENTAL | NETWORK | EFFICACY | DNA-DAMAGE | SELF-RENEWAL | PROLIFERATION | AZD1152 | MLN8237 | GENOME-WIDE | PHARMACOLOGY & PHARMACY | RUNX1/ETO | Index Medicus
Journal Article
07/2008
The t(8;21)(q22;q22) is one of the most frequent chromosomal abnormality associated with acute myeloid leukemia (AML) M2 sub type. The additional chromosomal... 
Xp22 | ETO/AML fusion | AML-M2 | Acute myeloid leukemia
Web Resource
Experimental & molecular medicine, ISSN 1226-3613, 04/2018, Volume 50, Issue 4, pp. 44 - 8
The AML1-ETO fusion protein (A/E), which results from the t(8;21) translocation, is considered to be a leukemia-initiating event. Identifying the mechanisms... 
AML1-ETO | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | PROTEIN | REPRESSION | WT1 | ACETYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | BINDING-SITES | EXPRESSION | PROMOTE | BRAIN | Chromosomes, Human, Pair 8 - genetics | Translocation, Genetic | Chromosomes, Human, Pair 21 - metabolism | Oncogene Proteins, Fusion - metabolism | Humans | Leukemia, Myeloid, Acute - metabolism | DNA Methylation | Cell Transformation, Neoplastic - genetics | U937 Cells | Nerve Tissue Proteins - biosynthesis | RUNX1 Translocation Partner 1 Protein - genetics | RUNX1 Translocation Partner 1 Protein - metabolism | Core Binding Factor Alpha 2 Subunit - metabolism | Leukemia, Myeloid, Acute - pathology | Membrane Proteins - genetics | Gene Silencing | THP-1 Cells | Repressor Proteins - genetics | Chromosomes, Human, Pair 21 - genetics | Cell Transformation, Neoplastic - metabolism | Nerve Tissue Proteins - genetics | Chromosomes, Human, Pair 8 - metabolism | Membrane Proteins - biosynthesis | Repressor Proteins - biosynthesis | Oncogene Proteins, Fusion - genetics | HL-60 Cells | Cell Transformation, Neoplastic - pathology | Core Binding Factor Alpha 2 Subunit - genetics | Leukemia, Myeloid, Acute - genetics | Nucleotide sequence | Myeloid leukemia | Leukemia | AML1 protein | Cell lines | Cell cycle | DNA methylation | Leukemogenesis | DNA methyltransferase | Fusion protein | Methylation | Acute myeloid leukemia | Binding sites | Apoptosis | 5-aza-2'-deoxycytidine | Index Medicus
Journal Article
The Oncologist, ISSN 1083-7159, 11/2018, Volume 23, Issue 11, pp. 1349 - 1357
摘要 背景。 研究确定, RUNX1‐RUNX1T1 转录水平是预测 t(8;21) 急性髓性白血病 (AML) 患者复发的有力标志物。我们旨在确定微小残留病 (MRD) 定向干扰素‐α (IFN‐α) 治疗对在异基因造血干细胞移植(allo‐HSCT)后 MRD阳性的 (8;21) AML 患者(n =... 
Minimal residual disease | Interferon‐α | Acute myeloid leukemia | RUNX1‐RUNX1T1 | Hematopoietic stem cell transplantation | Interferon-α | RUNX1-RUNX1T1 | AML | PROGNOSTIC-FACTORS | Interferon-alpha | BONE-MARROW-TRANSPLANTATION | RISK STRATIFICATION | VERSUS-HOST-DISEASE | CHEMOTHERAPY | ACUTE LEUKEMIA/MYELODYSPLASTIC SYNDROME | DONOR LYMPHOCYTE INFUSION | ONCOLOGY | HEMATOLOGICAL MALIGNANCIES | OUTCOMES
Journal Article
International Journal of Cancer, ISSN 0020-7136, 02/2017, Volume 140, Issue 3, pp. 653 - 661
Journal Article
Journal Article
by Zhou, L and Fu, L and Lv, N and Chen, XS and Liu, J and Li, Y and Xu, QY and Huang, S and Zhang, XD and Dou, LP and Wang, LL and Li, YH and Yu, L
EUROPEAN REVIEW FOR MEDICAL AND PHARMACOLOGICAL SCIENCES, ISSN 1128-3602, 02/2017, Volume 21, Issue 4, pp. 786 - 794
OBJECTIVE: The AML1-ETO fusion protein (AE) resulting from the t(8;21) translocation is highly related to the pathogenesis and development of leukemia.... 
AML1-ETO | CELLS | APOPTOSIS | ACTIVATION | SIRT1 | CANCER | MicroRNA | INHIBITION | t(8;21) | Leukemogenesis | PHARMACOLOGY & PHARMACY | DIFFERENTIATION | Acute myeloid leukemia | EXPRESSION | MIR-9 | HISTONE DEACETYLASE
Journal Article
Chemistry & Biodiversity, ISSN 1612-1872, 11/2018, Volume 15, Issue 11, pp. e1800314 - n/a
Polyphyllin I (PPI), a bioactive constituent extracted from traditional medicinal herbs, is cytotoxic to several cancer types. However, whether PPI can be used... 
AML | AML1-ETO | apoptosis | C-KIT | polyphyllin I | cytotoxicity | PATHWAYS | TARGET | CELLS | BIOCHEMISTRY & MOLECULAR BIOLOGY | AKT | CHEMISTRY, MULTIDISCIPLINARY | FUSION PROTEIN | CANCER STATISTICS | EXPRESSION | Chromosomes, Human, Pair 8 - genetics | Apoptosis - drug effects | Humans | Leukemia, Myeloid, Acute - metabolism | Molecular Conformation | Structure-Activity Relationship | Proto-Oncogene Proteins c-kit - metabolism | Proto-Oncogene Proteins c-kit - antagonists & inhibitors | Dose-Response Relationship, Drug | Leukemia, Myeloid, Acute - drug therapy | RUNX1 Translocation Partner 1 Protein - metabolism | Tumor Cells, Cultured | Proto-Oncogene Proteins c-akt - metabolism | Cell Survival - drug effects | Diosgenin - analogs & derivatives | Diosgenin - pharmacology | Core Binding Factor Alpha 2 Subunit - metabolism | Medicine, Chinese Traditional | Core Binding Factor Alpha 2 Subunit - antagonists & inhibitors | Leukemia, Myeloid, Acute - pathology | Antineoplastic Agents, Phytogenic - chemistry | RUNX1 Translocation Partner 1 Protein - antagonists & inhibitors | Diosgenin - chemistry | Chromosomes, Human, Pair 21 - genetics | Down-Regulation - drug effects | Signal Transduction - drug effects | Cell Proliferation - drug effects | Antineoplastic Agents, Phytogenic - pharmacology | Proto-Oncogene Proteins c-akt - antagonists & inhibitors | Drug Screening Assays, Antitumor | Medicine, Botanic | Medicine, Herbal | Apoptosis | Medicinal plants | Myeloid leukemia | Therapeutic applications | Leukemia | Medicinal herbs | Staining | Cytotoxicity | AKT protein | Survivin | Dosage | Proteins | Herbal medicine | Time dependence | Signaling | AML1 protein | Cholecystokinin | Acute myeloid leukemia | Cancer | Index Medicus
Journal Article