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2019, ISBN 9781717836793, 222 pages
This book by internationally-acclaimed researcher and speaker Sarah Weise will teach you the new rules for marketing and brand-building for Generation Z.... 
Psychological aspects | Generation Z | Target marketing | Marketing
Book
Circulation research, ISSN 1524-4571, 2018, Volume 122, Issue 3, pp. 489 - 505
The mTOR (mechanistic target of rapamycin) is a master regulator of several crucial cellular processes, including protein synthesis, cellular growth,... 
Heart | Mice | Cardiovascular diseases | Autophagy | Hypertrophy | MAMMALIAN TARGET | CARDIAC & CARDIOVASCULAR SYSTEMS | autophagy | ACTIVATED PROTEIN-KINASE | RAG GTPASES | hypertrophy | MYOCARDIAL-ISCHEMIA | cardiovascular diseases | DIET-INDUCED OBESITY | mice | heart | ISCHEMIA-REPERFUSION INJURY | TERM CALORIC RESTRICTION | CARDIAC-HYPERTROPHY | PERIPHERAL VASCULAR DISEASE | PROMOTES HEART-FAILURE | TUBEROUS SCLEROSIS | HEMATOLOGY | Adaptation, Physiological | Mechanistic Target of Rapamycin Complex 1 - physiology | Mechanistic Target of Rapamycin Complex 2 - physiology | Protein Biosynthesis | Humans | Stress, Mechanical | Hypoxia - metabolism | Organelle Biogenesis | Mammals - physiology | TOR Serine-Threonine Kinases - physiology | Cardiovascular Physiological Phenomena | Signal Transduction | Cell Survival | Heart Diseases - physiopathology | Mechanistic Target of Rapamycin Complex 1 - deficiency | Models, Cardiovascular | Mechanistic Target of Rapamycin Complex 2 - deficiency | Gene Expression Regulation | Cardiomegaly - physiopathology | Lipid Metabolism | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Mitochondria - metabolism | Heart Diseases - enzymology | Animals | Energy Metabolism | Heart Diseases - drug therapy | Cell proliferation | Cardiovascular system | Heart failure | Care and treatment | Analysis | Cell metabolism | Physiological aspects | Protein biosynthesis | Rapamycin | Dosage and administration | Research | Cardiopulmonary system | mTOR signaling | mTORC2 | mTORC1 | reperfusion | ischemia
Journal Article
Nature (London), ISSN 1476-4687, 2017, Volume 552, Issue 7685, pp. 368 - 373
The mechanistic target of rapamycin complex 1 (mTORC1) controls cell growth and metabolism in response to nutrients, energy levels, and growth factors. It... 
MAMMALIAN TARGET | RAPTOR | COMPLEX | PHOSPHORYLATION | SUBSTRATE | TOR | MULTIDISCIPLINARY SCIENCES | CELL-GROWTH | MUTATIONS | CRYO-EM STRUCTURE | P70 S6 KINASE | Adaptor Proteins, Signal Transducing - chemistry | Humans | Mechanistic Target of Rapamycin Complex 1 - chemistry | Substrate Specificity | Crystallography, X-Ray | Ras Homolog Enriched in Brain Protein - metabolism | Neoplasms - genetics | Protein Domains | Ras Homolog Enriched in Brain Protein - ultrastructure | Binding Sites | Catalytic Domain | Biocatalysis | Ribosomal Protein S6 Kinases, 70-kDa - metabolism | Signal Transduction | Models, Molecular | Mechanistic Target of Rapamycin Complex 1 - antagonists & inhibitors | Sirolimus - metabolism | Ras Homolog Enriched in Brain Protein - chemistry | Amino Acid Motifs | Cryoelectron Microscopy | Mechanistic Target of Rapamycin Complex 1 - agonists | Mechanistic Target of Rapamycin Complex 1 - ultrastructure | Tacrolimus Binding Protein 1A - metabolism | Protein Binding | Regulatory-Associated Protein of mTOR - chemistry | Enzyme Activation | Mutation | Adaptor Proteins, Signal Transducing - metabolism | Regulatory-Associated Protein of mTOR - metabolism | Protein research | Research | Guanosine triphosphatase | Protein kinases | TOR signalling | Kinases | BASIC BIOLOGICAL SCIENCES | Cryoelectron microscopy | Oncogenes
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 2018, Volume 293, Issue 44, pp. 17229 - 17239
Journal Article
ACS Chemical Biology, ISSN 1554-8929, 01/2011, Volume 6, Issue 1, pp. 34 - 46
Small-molecule target identification is a vital and daunting task for the chemical biology community as well as for researchers interested in applying the... 
IMMUNOSUPPRESSANT FK506 | CYTOSOLIC BINDING-PROTEIN | CHEMICAL GENETICS | Target identification | NATURAL-PRODUCTS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MAMMALIAN PROTEIN | 2D-PAGE | SILAC | FKBP12-RAPAMYCIN COMPLEX | HUMAN GROWTH-HORMONE | Degradomics | LIQUID-CHROMATOGRAPHY | Affinity chromatography | Drug affinity responsive target stability (DARTS) | MudPIT | HYDROGEN-EXCHANGE | COLCHICINE-BINDING | Small Molecule Libraries - chemistry | Chromatography, Affinity | Drug Design | Proteomics | Pharmaceutical Preparations | Proteome - chemistry | Molecular Targeted Therapy - methods | Drug Delivery Systems | Protein Binding - physiology | Drug affinity responsive target stability (DARTS): A method for target identification that relies on drug-induced protease resistance | Reviews | Affinity chromatography: Traditional method of target identification that uses immobilized small molecules to pull down binding proteins from a complex protein mixture | 2D-PAGE: A two-dimensional gel-based method that combines isoelectric focusing and SDS–PAGE to separate proteins by charge and molecular weight | Target identification: Determination of which proteins a particular small molecule binds in the cell | Degradomics: The subfield of proteomics devoted to the study of proteases and their biological substrates | SILAC: Stable isotope labeling of amino acids in cell culture | MudPIT: A gel-free proteomics technique that uses online separation of tryptic peptides by strong cation exchange and reversed-phase HPLC to analyze very complex protein mixtures by mass spectrometry
Journal Article