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1. Full Text Synthesis and biological activity of 3-guanidino-6-R-imidazo[1,2-b]- and 6-guanidino-3-R-[1,2,4]triazolo[4,3-b][1,2,4,5]tetrazines
by Ishmetova, R I and Ignatenko, N K and Korotina, A V and Ganebnykh, I N and Slepukhin, P A and Babkova, V A and Gerasimova, N A and Evstigneeva, N P and Zilberberg, N V and Kungurov, N V and Rusinov, G L and Spasov, A A and Chupakhin, O N
Russian Chemical Bulletin, ISSN 1066-5285, 11/2018, Volume 67, Issue 11, pp. 2079 - 2087
The reaction of azoloannulated [1,2,4,5]tetrazines with guanidine was studied. New 3-guanidinoimidazo[1,2-b]- and 6-guanidino[1,2,4]triazolo[4,3-b]... 
guanidine | antiglycation activity | antibacterial activity | Chemistry | 1,2,4,5-tetrazines | Chemistry/Food Science, general | nucleophilic substitution | imidazo[1,2- b ][1,2,4,5]tetrazines | Inorganic Chemistry | Organic Chemistry | [1,2,4]triazolo[4,3- b ]- [1,2,4,5] tetrazines | imidazo[1,2-b][1,2,4,5]tetrazines | [1,2,4]triazolo[4,3-b]- [1,2,4,5] tetrazines | 5]tetrazines | 4]triazolo | 2-b | CHEMISTRY, MULTIDISCIPLINARY | ANTITUMOR EVALUATION | imidazo | 5] tetrazines | 3-b]-
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2. Chemistry of 1,2,3-triazines and 1,2,4-triazines, tetrazines, and pentazines
by Neunhoeffer, Hans and Wiley, Paul Fears
1978, ISBN 0471031291, Volume 33., xxv, 1335
Triazines | Pentazine | Tetrazine
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3. Full Text Improved radiosynthesis and preliminary in vivo evaluation of the 11 C-labeled tetrazine [ 11 C]AE-1 for pretargeted PET imaging
by Stéen, E. Johanna L and Jørgensen, Jesper T and Petersen, Ida N and Nørregaard, Kamilla and Lehel, Szabolcs and Shalgunov, Vladimir and Birke, Alexander and Edem, Patricia E and L'Estrade, Elina T and Hansen, Hanne D and Villadsen, Jonas and Erlandsson, Maria and Ohlsson, Tomas and Yazdani, Abdolreza and Valliant, John F and Kristensen, Jesper L and Barz, Matthias and Knudsen, Gitte M and Kjær, Andreas and Herth, Matthias M
Bioorganic and Medicinal Chemistry Letters, ISSN 0960-894X, 04/2019, Volume 29, Issue 8, pp. 986 - 990
Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with trans-cyclooctene (TCO) has recently... 
Carbon-11 | PET imaging | Trans-cyclooctene | Pretargeting | Tetrazine
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4. Full Text Improved radiosynthesis and preliminary in vivo evaluation of the 11C-labeled tetrazine [11C]AE-1 for pretargeted PET imaging
by Stéen, E. Johanna L and Jørgensen, Jesper T and Petersen, Ida N and Nørregaard, Kamilla and Lehel, Szabolcs and Shalgunov, Vladimir and Birke, Alexander and Edem, Patricia E and L'Estrade, Elina T and Hansen, Hanne D and Villadsen, Jonas and Erlandsson, Maria and Ohlsson, Tomas and Yazdani, Abdolreza and Valliant, John F and Kristensen, Jesper L and Barz, Matthias and Knudsen, Gitte M and Kjær, Andreas and Herth, Matthias M
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 04/2019, Volume 29, Issue 8, pp. 986 - 990
Pretargeted nuclear imaging based on the ligation between tetrazines and nano-sized targeting agents functionalized with -cyclooctene (TCO) has recently been... 
Carbon-11 | PET imaging | Trans-cyclooctene | Pretargeting | Tetrazine
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5. Full Text Single‐Junction Polymer Solar Cells with 16.35% Efficiency Enabled by a Platinum(II) Complexation Strategy
by Xu, Xiaopeng and Feng, Kui and Bi, Zhaozhao and Ma, Wei and Zhang, Guangjun and Peng, Qiang
Advanced Materials, ISSN 0935-9648, 07/2019, Volume 31, Issue 29, pp. e1901872 - n/a
A new strategy of platinum(II) complexation is developed to regulate the crystallinity and molecular packing of polynitrogen heterocyclic polymers, optimize... 
s‐tetrazine | nonfullerene polymer solar cells | platinum(II) complexation | wide‐bandgap polymers | morphology control | wide-bandgap polymers | s-tetrazine | PHYSICS, CONDENSED MATTER | DESIGN | PHYSICS, APPLIED | SMALL-MOLECULE | MATERIALS SCIENCE, MULTIDISCIPLINARY | CHEMISTRY, PHYSICAL | NANOSCIENCE & NANOTECHNOLOGY | ADDITIVES | CHEMISTRY, MULTIDISCIPLINARY | SIDE-CHAINS | FULLERENE | DONOR POLYMERS | ACCEPTOR | Solar cells | Solar batteries | Polymer industry | Complexation | Polymer blends | Steric hindrance | Agglomeration | Domains | Indene | Photovoltaic cells | Platinum | Efficiency | Morphology | Benzene | Phase separation | Dimethyl sulfoxide | Polymers | Energy conversion efficiency
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6. Full Text Synthesis, crystal structures and biological evaluation of new pyridazine derivatives
by Singh, Bholey and Bhatia, Rohit and Pani, Balaram and Gupta, Deepak
Journal of Molecular Structure, ISSN 0022-2860, 01/2020, Volume 1200, p. 127084
A series of functionalized pyridazine derivatives ( – ) 4-yl , 4-yl 4-yl , 3-yl 4-yl , 4-yl 2-yl , 4-yl 5 , 3-yl , 4-yl 3-yl , 3-yl , 3-yl 2-yl , 3-yl were... 
Anti-biotic | Diels-alder | Tetrazine | Pyridazine | Crystal | TETRAZINES | CHEMISTRY | CHEMISTRY, PHYSICAL
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7. Full Text Polycyclic: N-oxides: High performing, low sensitivity energetic materials
by Snyder, Christopher J and Wells, Lucille A and Chavez, David E and Imler, Gregory H and Parrish, Damon A
Chemical Communications, ISSN 1359-7345, 2019, Volume 55, Issue 17, pp. 2461 - 2464
Polycyclic N-oxides were developed based on the heterocycles 1,2,4,5-tetrazine and 4H, 8H-difurazano[3,4-b:3',4'-e]pyrazine. The new compounds are energetic... 
CHEMISTRY | REDOX | CRYSTAL PACKING | TETRAZINE | CHEMISTRY, MULTIDISCIPLINARY | FUSED HETEROCYCLE
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8. Full Text Polycyclic N-oxides: high performing, low sensitivity energetic materials
by Snyder, Christopher J and Wells, Lucille A and Chavez, David E and Imler, Gregory H and Parrish, Damon A
Chemical communications (Cambridge, England), ISSN 1359-7345, 02/2019, Volume 55, Issue 17, pp. 2461 - 2464
Polycyclic N-oxides were developed based on the heterocycles 1,2,4,5-tetrazine and 4H,8H-difurazano[3,4-b:3',4'-e]pyrazine. The new compounds are energetic and... 
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9. Full Text Sydnone-based turn-on fluorogenic probes for no-wash protein labeling and in-cell imaging
by Plougastel, L and Pattanayak, MR and Riomet, M and Bregant, S and Sallustrau, A and Nothisen, M and Wagner, A and Audisio, D and Taran, F
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 04/2019, Volume 55, Issue 31, pp. 4582 - 4585
We report the synthesis and use of sydnone-based profluorophores as tools for imaging applications. These new probes display exquisite reactivity towards... 
CHEMISTRY | CHEMISTRY, MULTIDISCIPLINARY | TETRAZINE PROBES
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10. Full Text Cover Picture: Conditional Singlet Oxygen Generation through a Bioorthogonal DNA‐targeted Tetrazine Reaction (Angew. Chem. Int. Ed. 37/2019)
by Linden, Greta and Zhang, Lei and Pieck, Fabian and Linne, Uwe and Kosenkov, Dmitri and Tonner, Ralf and Vázquez, Olalla
Angewandte Chemie International Edition, ISSN 1433-7851, 09/2019, Volume 58, Issue 37, pp. 12719 - 12719
Tetrazine can act as an effective singlet oxygen quencher of halogenated BODIPY photosensitizers. In their Communication on page 12868 ff., O. Vázquez and... 
bioorthogonal reactions | singlet oxygen | tetrazine | photodynamic therapy | BODIPY dyes
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11. Full Text Microwave-promoted synthesis of highly luminescent s-tetrazine-1,3,4-oxadiazole and s-tetrazine-1,3,4-thiadiazole hybrids
by Kędzia, Anna and Kudelko, Agnieszka and Świątkowski, Marcin and Kruszyński, Rafał
Dyes and Pigments, ISSN 0143-7208, 01/2020, Volume 172, p. 107865
Two series of new -tetrazine derivatives containing 1,3,4-oxadiazole and 1,3,4-thiadiazole rings were synthesized from -tetrazine-3,6-dicarbohydrazide,... 
Microwave | Cyclocondensation | 1,3,4-Thiadiazole | 1,3,4-Oxadiazole | Luminescence properties | s-Tetrazine | 1,2,4,5-TETRAZINE | TETRAZINE | MATERIALS SCIENCE, TEXTILES | SULFONE DERIVATIVES | 3D-QSAR | ENGINEERING, CHEMICAL | FLUORESCENCE | CHEMISTRY, APPLIED
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12. Full Text Metal‐Catalyzed One‐Pot Synthesis of Tetrazines Directly from Aliphatic Nitriles and Hydrazine
by Yang, Jun and Karver, Mark R and Li, Weilong and Sahu, Swagat and Devaraj, Neal K
Angewandte Chemie International Edition, ISSN 1433-7851, 05/2012, Volume 51, Issue 21, pp. 5222 - 5225
Paving the way: The lack of convenient synthetic methods is a significant roadblock to the broader use of 1,2,4,5‐tetrazines in bioorthogonal chemistry and... 
bioorthogonal synthesis | cycloaddition | heterocycles | metal catalysis | tetrazines | ONE-STEP SYNTHESIS | COMPLEXES | LIGATION | CHEMISTRY, MULTIDISCIPLINARY | MOLECULES | PROBES | AMINES | CHEMISTRY | Lewis acid | Hydrazines | Synthesis | Nitriles | Nickel | Paving | Zinc | Aliphatic compounds | catalysis | bioorthogonal | heterocycle | tetrazine
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13. Full Text Bio-orthogonal "click-and-release'' donation of caged carbonyl sulfide (COS) and hydrogen sulfide (H2S)
by Steiger, AK and Yang, Y and Royzen, M and Pluth, MD
CHEMICAL COMMUNICATIONS, ISSN 1359-7345, 01/2017, Volume 53, Issue 8, pp. 1378 - 1380
Hydrogen sulfide (H2S) is an important biomolecule with high therapeutic potential. Here we leverage the inverse-electron demand Diels-Alder (IEDDA) click... 
DRUG | GASOTRANSMITTER | VIVO BIOORTHOGONAL CHEMISTRY | FLUORESCENT-PROBES | DONORS | MICE | TETRAZINE LIGATION | CHEMISTRY, MULTIDISCIPLINARY | LIVING CELLS
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14. Full Text Constructing New Bioorthogonal Reagents and Reactions
by Row, R. David and Prescher, Jennifer A
Accounts of Chemical Research, ISSN 0001-4842, 05/2018, Volume 51, Issue 5, pp. 1073 - 1081
Conspectus Chemical tools are transforming our understanding of biomolecules and living systems. Included in this group are bioorthogonal reagents–functional... 
DRUG | CELLS | 1,2,4-TRIAZINES | GENETIC-CODE | CYCLOPROPENE FATTY-ACIDS | CYCLOADDITIONS | CHEMISTRY | TETRAZINE LIGATION | IDENTIFICATION | CHEMISTRY, MULTIDISCIPLINARY | DISCOVERY
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15. Full Text A Bifunctional Fluorogenic Rhodamine Probe for Proximity-Induced Bioorthogonal Chemistry
by Werther, P and Mchler, JS and Wombacher, R
CHEMISTRY-A EUROPEAN JOURNAL, ISSN 0947-6539, 12/2017, Volume 23, Issue 72, pp. 18216 - 18224
Bioorthogonal reactions have emerged as a versatile tool in life sciences. The inverse electron demand Diels-Alder reaction (DA(inv)) stands out due to the... 
ACID-TEMPLATED REACTIONS | STAUDINGER REACTION | TRANS-CYCLOOCTENE | TETRAZINE LIGATION | CHEMISTRY, MULTIDISCIPLINARY | LIVE-CELL | proteins | IMPROVED STABILITY | DIELS-ALDER REACTION | dienophiles | LIVING SYSTEMS | FLUORESCENCE DETECTION | kinetics | tetrazine | DIRECTED TOSYL CHEMISTRY | rhodamine
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16. Full Text F-18-Based Pretargeted PET Imaging Based on Bioorthogonal Diels Alder Click Chemistry
by Meyer, JP and Houghton, JL and Kozlowski, P and Abdel-Atti, D and Reiner, T and Pillarsetty, NVK and Scholz, WW and Zeglis, BM and Lewis, JS
BIOCONJUGATE CHEMISTRY, ISSN 1043-1802, 02/2016, Volume 27, Issue 2, pp. 298 - 301
A first-of-its-kind F-18 pretargeted PET imaging approach based on the bioorthogonal inverse electron demand Diels-Alder (IEDDA) reaction between tetrazine... 
PEPTIDES | TETRAZINE | STRATEGY | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | CHEMISTRY, ORGANIC | CHEMISTRY, MULTIDISCIPLINARY | CA19.9
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17. Full Text Counting primary loops in polymer gels
by Huaxing Zhou and Jiyeon Woo and Alexandra M. Cok and Muzhou Wang and Bradley D. Olsen and Jeremiah A. Johnson
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 11/2012, Volume 109, Issue 47, pp. 19119 - 19124
Much of our fundamental knowledge related to polymer networks is built on an assumption of ideal end-linked network structure. Real networks invariably possess... 
Gels | Hydrogels | Quantification | Gelation | Macromolecules | Materials | Mechanical properties | Polymers | Functional groups | Monomers | Network disassembly spectrometry | Responsive materials | Topology | Tetrazine | MATRIX | HYDROGELS | LINEAR RANDOM POLYMERIZATION | topology | MULTIDISCIPLINARY SCIENCES | MOLECULAR-SIZE DISTRIBUTION | GELATION | responsive materials | network disassembly spectrometry | TETRAZINES | GROWTH | MODEL NETWORKS | BIOMATERIALS | tetrazine | INTRAMOLECULAR REACTION | Structure | Chemical properties | Physical Sciences
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18. Full Text Synthesis and Pharmacological Studies of Unprecedented Fused Pyridazino[3,4:5,6] [1,2,4] triazino[3,4-b][1,3,4]thiadiazine Derivatives
by Ali, Rania S and Saad, Hosam A
Molecules, ISSN 1420-3049, 2018, Volume 23, Issue 5, p. 1024
A novel fused system with three or four fused ringspyridazino[3,4:5,6][1,2,4]triazino[4,3-b][1,2,4,5]tetrazine and... 
Cyclization reactions | Biological applications | 3-b | Antitumor activity | Pyridazino | 5]tetrazine | 4]triazino | 4:5 | cyclization reactions | NITROGEN SYSTEMS BEARING | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | ANTI-HIV | biological applications | IDENTIFICATION | pyridazino[3 ',4 ':5,6][1,2,4]triazino[4,3-b][1,2,4,5]tetrazine | ANTITUMOR | CHEMISTRY, MULTIDISCIPLINARY | antitumor activity | 1,2,4-TRIAZINE MOIETY | ANTICANCER DRUGS | CYTOTOXIC AGENTS | THIOPHENES | Cell Survival - drug effects | Thiadiazines - chemical synthesis | Antineoplastic Agents - chemical synthesis | HCT116 Cells | Humans | Antineoplastic Agents - chemistry | Hep G2 Cells | Thiadiazines - chemistry | Cyclization | MCF-7 Cells | Antineoplastic Agents - pharmacology | Cell Proliferation - drug effects | Molecular Structure | Thiadiazines - pharmacology | Synthesis | Reagents | Cell lines | Data processing | Triazine | Chemical reactions | Pharmacology | Anticancer properties | pyridazino[3′,4′:5,6][1,2,4]triazino[4,3-b][1,2,4,5]tetrazine
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19. Full Text Di-cysteine S,S-tetrazine: A potential ultra-fast photochemical trigger to explore the early events of peptide/protein folding
by Tucker, Matthew J and Abdo, Mohannad and Courter, Joel R and Chen, Jianxin and Smith, Amos B and Hochstrasser, Robin M
Journal of Photochemistry & Photobiology, A: Chemistry, ISSN 1010-6030, 04/2012, Volume 234, pp. 156 - 163
► New photochemistry by symmetric sulfur substitution of s-tetrazines. ► Stepwise photocleavage of cysteine S,S-tetrazine tracked by femtosecond IR. ► Peptide... 
Phototrigger | Phototolysis | Peptides | Infrared | Tetrazine | DIMETHYL-S-TETRAZINE | NONDENATURING ENVIRONMENT | HELIX NUCLEATION | CONFIGURATION-INTERACTION | CHEMISTRY, PHYSICAL | N-HETEROAROMATIC SYSTEMS | PHOTO-DISSOCIATION | UNIMOLECULAR TRIPLE DISSOCIATION | PICOSECOND CONFORMATIONAL TRANSITION | SYM-TETRAZINE | ELECTRONIC-STRUCTURE | Chemical properties
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20. Full Text Next-generation disulfide stapling: reduction and functional re-bridging all in one
by Lee, Maximillian T W and Maruani, Antoine and Baker, James R and Caddick, Stephen and Chudasama, Vijay
Chemical science, ISSN 2041-6520, 01/2016, Volume 7, Issue 1, pp. 799 - 802
Herein we present a significant step towards next-generation disulfide stapling reagents. A novel class of reagent has been designed to effect both disulfide... 
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