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Journal of inorganic biochemistry, ISSN 0162-0134, 2018, Volume 178, pp. 18 - 31
Journal Article
Organic & biomolecular chemistry, ISSN 1477-0539, 2019, Volume 17, Issue 25, pp. 6178 - 6183
A novel coumarin photocage with long-wavelength and high photolysis quantum yield shows solvent dependent photolysis. Controlling the activity of biomolecules... 
OXYGEN | MECHANISM | TRIPLET-STATE | PHOTORELEASE | CHEMISTRY | CHEMISTRY, ORGANIC | TRANSIENT ABSORPTION | RELEASE | PHOTOREMOVABLE PROTECTING GROUPS | Thiones - radiation effects | Photolysis | Coumarins - radiation effects | Coumarins - chemical synthesis | Light | Thiones - chemistry | Coumarins - chemistry | Thiones - chemical synthesis
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2015, Volume 10, Issue 10, p. e0137305
Cytokines such as TNF alpha can polarize microglia/macrophages into different neuroinflammatory types. Skewing of the phenotype towards a cytotoxic state is... 
LEUKOCYTES | MICROGLIA | NEUROINFLAMMATION | ALZHEIMERS-DISEASE | HIPPOCAMPAL-LESIONS | BEHAVIOR | MULTIDISCIPLINARY SCIENCES | A-BETA | INNATE | PRECURSOR PROTEIN | BRAIN | Tumor Necrosis Factor-alpha - metabolism | Microglia - metabolism | Isoindoles - administration & dosage | Humans | Biological Availability | Male | Thiones - therapeutic use | tau Proteins - chemistry | Alzheimer Disease - pathology | Thiones - adverse effects | Brain - metabolism | Dose-Response Relationship, Drug | Isoindoles - therapeutic use | Female | Safety | Alzheimer Disease - immunology | Isoindoles - pharmacology | Cognition - classification | Macrophages - immunology | Neutrophil Infiltration - drug effects | Disease Models, Animal | Thioamides - administration & dosage | Cell Line | Immunity, Innate - drug effects | Microglia - drug effects | Administration, Oral | Isoindoles - adverse effects | Mice, Inbred C57BL | Solubility | Alzheimer Disease - drug therapy | Thioamides - pharmacology | Mice, Transgenic | Brain - drug effects | Phenotype | Animals | Protein Structure, Secondary - drug effects | Thiones - administration & dosage | Alzheimer Disease - metabolism | Brain - pathology | Macrophages - drug effects | Thioamides - therapeutic use | Mice | Thiones - pharmacology | Thioamides - adverse effects | Brain - immunology | Protein Multimerization - drug effects | Tumor Necrosis Factor-alpha - antagonists & inhibitors | Brain | Flow cytometry | Memory | Cognitive ability | Cytotoxicity | Nervous system | Systematic review | Cognition | Biochemistry | Arthritis | Macrophages | Neuromodulation | Modulators | Learning | Rodents | Tumor necrosis factor-TNF | Amyloid | Alzheimer's disease | Immune system | Phenotypes | Cytokines | Neutrophils | Inflammation | Bioavailability | Tumor necrosis factor-α | Microglia | Pathology | Cytometry | Tau protein | Infiltration | Alzheimers disease | Phagocytosis | Animal cognition
Journal Article
Journal Article
Applied Microbiology and Biotechnology, ISSN 0175-7598, 11/2016, Volume 100, Issue 21, pp. 9265 - 9281
Multi drug resistant (MDR) pathogens pose a serious threat to public health since they can easily render most potent drugs ineffective. Efflux pump inhibitors... 
Life Sciences | Biotechnology | Efflux pump inhibitor | Microbiology | Zebrafish infection | Microbial Genetics and Genomics | MRSA | Ciprofloxacin | Dithiazole thiones | MIC reversal | MYCOBACTERIUM-TUBERCULOSIS | BACTERIA | PROTEIN | ESCHERICHIA-COLI | ANTIBIOTIC-RESISTANCE | FLUOROQUINOLONE RESISTANCE | IDENTIFICATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | STAPHYLOCOCCUS-AUREUS | BLOOD-STREAM INFECTIONS | PATHOGENS | Bacterial Proteins - antagonists & inhibitors | Muscles - microbiology | Staphylococcal Infections - drug therapy | Skin - microbiology | Methicillin-Resistant Staphylococcus aureus - drug effects | Enzyme Inhibitors - pharmacology | Multidrug Resistance-Associated Proteins - antagonists & inhibitors | Thiazoles - administration & dosage | Treatment Outcome | Zebrafish | Gene Expression Profiling | Bacterial Load | Enzyme Inhibitors - chemical synthesis | Enzyme Inhibitors - administration & dosage | Animals | Ciprofloxacin - administration & dosage | Thiones - administration & dosage | Staphylococcal Infections - microbiology | Thiazoles - pharmacology | Thiones - pharmacology | Anti-Bacterial Agents - administration & dosage | Drug Resistance, Multiple, Bacterial - drug effects | Real-Time Polymerase Chain Reaction | Disease Models, Animal | Drug resistance in microorganisms | Observations | Health aspects | Staphylococcus aureus | Studies | Pathogens | Antibiotics | Analysis | Staphylococcus infections | Drug resistance
Journal Article
The Journal of experimental medicine, ISSN 1540-9538, 2017, Volume 214, Issue 11, pp. 3219 - 3238
The NLRP3 inflammasome has been implicated in the pathogenesis of a wide variety of human diseases. A few compounds have been developed to inhibit NLRP3... 
MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | BAY 11-7082 | MECHANISM | GOUT | NEK7 | BLOCKING INTERLEUKIN-1 | KAPPA-B | INFLAMMASOMES | IMMUNOLOGY | ATP-BINDING | BETA | Small Molecule Libraries - pharmacology | Inflammasomes - metabolism | Diabetes Mellitus, Type 2 - genetics | Humans | Immunoblotting | Diabetes Mellitus, Type 2 - metabolism | NLR Family, Pyrin Domain-Containing 3 Protein - genetics | Inflammation - metabolism | Inflammasomes - drug effects | Inflammation - drug therapy | HEK293 Cells | Adult | Molecular Structure | Thiazolidines - pharmacology | Thiazolidines - chemistry | Disease Models, Animal | Cryopyrin-Associated Periodic Syndromes - genetics | NLR Family, Pyrin Domain-Containing 3 Protein - metabolism | Mice, Inbred C57BL | Thiones - chemistry | NLR Family, Pyrin Domain-Containing 3 Protein - antagonists & inhibitors | Mice, Transgenic | Cryopyrin-Associated Periodic Syndromes - drug therapy | Inflammasomes - genetics | Mice, Knockout | Microscopy, Confocal | Small Molecule Libraries - chemistry | Animals | Cell Line, Tumor | Inflammation - genetics | Thiones - pharmacology | Diabetes Mellitus, Type 2 - drug therapy | Cryopyrin-Associated Periodic Syndromes - metabolism | Synovial fluid | Monocytes | Animal models | Inhibitors | Cryopyrin | Pathogenesis | Diabetes mellitus | Gout | Activation | Adenosine triphosphatase | Diseases | 311
Journal Article
SHOCK, ISSN 1073-2322, 01/2016, Volume 45, Issue 1, pp. 88 - 97
ABSTRACTThis study evaluated the effects of AP39 [(10-oxo-10-(4-(3-thioxo-3H-1,2-dithiol-5yl) phenoxy)decyl) triphenyl phosphonium bromide], a mitochondrially... 
S donor | mitochondria | oxidative stress | renal injury | ischemia | H2S donor | SURGERY | ACTIVATION | dichlorofluorescein | DMSO | MDA | H2O2 | MTT | MPO | cystathionine--lyase | GOx | FBS | triphenyl phosphonium | PERIPHERAL VASCULAR DISEASE | malondialdehyde | 5-Dimethyl-2-thizolyl)-2 | DCF | hydrogen peroxide | H2S | MECHANISMS | 5-diphenyltertazolium bromide | 3-MST | fetal bovine serum | hydrogen sulfide | ARF | glucose oxidase | aminooxyacetic acid | SEM | standard error of the mean | CELLULAR BIOENERGETICS | AP39 | blood urea nitrogen | 3-mercaptopyruvate sulfurtransferase | AOAA | 10-oxo-10-(4-(3-thioxo-3H-1 | acute renal failure | dimethyl sulfoxide | INHIBITION | CSE | METABOLISM | CBS | TPP | 2-dithiol-5yl) phenoxy)decyl) triphenylphosphonium bromide | BUN | MICE | DYSFUNCTION | interleukin | HEMATOLOGY | reperfusion | cystathionine--synthase (CBS) | ISCHEMIA/REPERFUSION | CRITICAL CARE MEDICINE | myeloperoxidase | FAILURE | adenosine triphosphate | ISCHEMIA-REPERFUSION | ATP | Hydrogen Sulfide - metabolism | Drug Evaluation, Preclinical - methods | Cell Hypoxia - drug effects | Cell Hypoxia - physiology | Epithelial Cells - drug effects | Cells, Cultured | Organophosphorus Compounds - therapeutic use | Male | Mitochondria - metabolism | Cytoprotection - physiology | Mitochondria - drug effects | Thiones - therapeutic use | Rats, Sprague-Dawley | Acute Kidney Injury - prevention & control | Dose-Response Relationship, Drug | Animals | Thiones - administration & dosage | Organophosphorus Compounds - pharmacology | Organophosphorus Compounds - administration & dosage | Oxidative Stress - drug effects | Thiones - pharmacology
Journal Article
Journal Article