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Free Radical Biology and Medicine, ISSN 0891-5849, 2011, Volume 50, Issue 6, pp. 689 - 699
Journal Article
Journal of Structural Biology, ISSN 1047-8477, 05/2016, Volume 194, Issue 2, pp. 180 - 190
The anti-arthritic gold-containing drug Auranofin is lethal to the protozoan intestinal parasite , the causative agent of human amebiasis, in both culture and... 
Entamoeba histolytica | Human amebiasis | Thioredoxin | Thioredoxin reductase | X-ray structure | Auranofin | GLUTATHIONE-REDUCTASE | CATALYSIS | CYSTEINE PK(A) VALUES | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESOLUTION | SACCHAROMYCES-CEREVISIAE | GOLD COMPOUNDS | CELL BIOLOGY | IN-VITRO | BIOPHYSICS | ESCHERICHIA-COLI THIOREDOXIN | GIARDIA-DUODENALIS | Thioredoxin-Disulfide Reductase - genetics | Protozoan Proteins - antagonists & inhibitors | Crystallography, X-Ray | Protozoan Proteins - genetics | Entamoeba histolytica - chemistry | Protozoan Proteins - metabolism | Thioredoxins - genetics | Thioredoxin-Disulfide Reductase - metabolism | Disulfides - chemistry | Entamoeba histolytica - enzymology | Cloning, Molecular | Escherichia coli - metabolism | Protein Domains | Protozoan Proteins - chemistry | Thioredoxins - metabolism | Thioredoxins - antagonists & inhibitors | Thioredoxins - chemistry | Thioredoxin-Disulfide Reductase - chemistry | Recombinant Proteins - metabolism | Amino Acid Sequence | Catalytic Domain | Gene Expression | Auranofin - chemistry | Oxidation-Reduction | Protein Structure, Secondary | Models, Molecular | Recombinant Proteins - chemistry | Antiprotozoal Agents - chemistry | Recombinant Proteins - genetics | Sequence Alignment | Escherichia coli - genetics | Thioredoxin-Disulfide Reductase - antagonists & inhibitors | Antirheumatic Agents - chemistry | Mutation | Analysis | Medical colleges | Parasitic diseases | Escherichia coli | Index Medicus | human amebiasis | x-ray structure | thioredoxin | thioredoxin reductase
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 08/2016, Volume 97, pp. 1 - 13
Low molecular mass thiols and antioxidant enzymes have essential functions to detoxify reactive oxygen and nitrogen species maintaining cellular redox balance.... 
Peroxiredoxin | Redox metabolism | Thioredoxin reductase | Leptospira | DTNB 5,5′-dithiobis(2-nitrobenzoic acid) | L-TrxR low molecular mass thioredoxin reductase | CDNB 1-chloro-2,4-dinitrobenzene | MBQ 2-methyl-benzoquinone | t-BuOOH tert-butyl hydroperoxide | GSSG glutathione disulfide | Trx thioredoxin | DTT dithiothreitol | H-TrxR high molecular mass thioredoxin reductase | Abbreviations AhpC bacterial 2-Cys peroxiredoxin | bis-γ-GC bis-γ-glutamylcysteine | TrxR thioredoxin reductase | SYSTEM | METHYLENE-BLUE | OXIDATIVE STRESS | BIOCHEMISTRY & MOLECULAR BIOLOGY | ENTAMOEBA-HISTOLYTICA | IN-VITRO SUSCEPTIBILITIES | INTRACELLULAR REDOX | TREPONEMA-PALLIDUM | METABOLISM | GLUTATHIONE | ENDOCRINOLOGY & METABOLISM | PARASITE PLASMODIUM-FALCIPARUM | Recombinant Proteins - metabolism | Reactive Oxygen Species - metabolism | Oxidation-Reduction | Thioredoxin-Disulfide Reductase - genetics | Reactive Nitrogen Species - metabolism | Antioxidants - metabolism | Humans | Peroxiredoxins - metabolism | Oxidative Stress - genetics | Leptospira interrogans - pathogenicity | Glutathione Disulfide - metabolism | Recombinant Proteins - genetics | Leptospirosis - metabolism | Thioredoxins - genetics | Thioredoxin-Disulfide Reductase - metabolism | Escherichia coli - genetics | Leptospira interrogans - metabolism | Sulfhydryl Compounds - chemistry | Thioredoxins - metabolism | Kinetics | Leptospirosis - microbiology | Thioredoxins - chemistry | Dithionitrobenzoic Acid - metabolism | Thioredoxin-Disulfide Reductase - chemistry | Antioxidants | Enzymes | Cysteine | Thiols | Analysis | Escherichia coli | Thioredoxin | Cystine | Physiological aspects
Journal Article