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Biomaterials, ISSN 0142-9612, 06/2015, Volume 53, pp. 437 - 452
Carbon nanotubes (CNTs) are a novel nanocarriers with interesting physical and chemical properties. Here we investigate the ability of amino-functionalized... 
Transcytosis | PBEC | TEM | Transwells | BBB model | STEM
Journal Article
Neuron, ISSN 0896-6273, 01/2014, Volume 81, Issue 1, pp. 49 - 60
Although biotherapeutics have vast potential for treating brain disorders, their use has been limited due to low exposure across the blood-brain barrier (BBB).... 
CLATHRIN-MEDIATED ENDOCYTOSIS | TRANSFERRIN RECEPTOR | BARRIER | MICE | EXPRESSION | BINDING | NEUROSCIENCES | DELIVERY | Humans | Transcytosis - genetics | Protein Transport - physiology | Protein Transport - drug effects | Alzheimer Disease - pathology | Brain - metabolism | Dose-Response Relationship, Drug | Single-Chain Antibodies - metabolism | Lysosomes - metabolism | Time Factors | Protein Binding - drug effects | Amyloid beta-Peptides - metabolism | Single-Chain Antibodies - therapeutic use | Macrolides - pharmacology | Disease Models, Animal | Lysosomes - drug effects | Single-Chain Antibodies - pharmacology | Subcellular Fractions - drug effects | Alzheimer Disease - therapy | Enzyme Inhibitors - pharmacology | Presenilin-1 - genetics | Mice, Transgenic | Transcytosis - immunology | Protein Binding - immunology | Blood-Brain Barrier - drug effects | Receptors, Transferrin - metabolism | Subcellular Fractions - metabolism | Blood-Brain Barrier - metabolism | Brain - drug effects | Models, Immunological | Amyloid beta-Protein Precursor - genetics | Animals | Receptors, Transferrin - immunology | Amyloid beta-Peptides - immunology | Mice | Transcytosis - drug effects | Alzheimer Disease - genetics | Brain - immunology | Cell Line, Transformed | Viral antibodies | Analysis | Amyloid beta-protein | Antibodies | Chemical properties | Health aspects | Alzheimer's disease | Biopharmaceutics | Transferrin | Proteins | Cell culture | Ligands | Recycling | Membrane filters
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 7/2012, Volume 109, Issue 31, pp. 12680 - 12685
The constant heavy chain (CH1) domain affects antibody affinity and fine specificity, challenging the paradigm that only variable regions contribute to antigen... 
T lymphocytes | Isotypes | HIV | Epithelial cells | Antibodies | Viruses | Transcytosis | Infections | Epitopes | HIV 1 | Antibody structure | HIV-1 envelope gp41 | Mimotope | Mucosa | HIV-1 | DENDRITIC CELLS | SERONEGATIVE INDIVIDUALS | MULTIDISCIPLINARY SCIENCES | GP41 | HUMAN MONOCLONAL-ANTIBODY | HUMAN-IMMUNODEFICIENCY-VIRUS | EPITHELIAL TRANSCYTOSIS | antibody structure | ANTIGEN-BINDING AFFINITY | mimotope | REGION | TYPE-1 | mucosa | Antibody Specificity | HIV Envelope Protein gp41 - genetics | HIV-1 - pathogenicity | HIV Envelope Protein gp41 - immunology | Humans | Acquired Immunodeficiency Syndrome - therapy | CD4-Positive T-Lymphocytes - immunology | Epitopes - immunology | Acquired Immunodeficiency Syndrome - immunology | Antibodies, Neutralizing - immunology | HIV Antibodies - immunology | Immunoglobulin G - immunology | Immunoglobulin G - pharmacology | CD4-Positive T-Lymphocytes - virology | HIV Antibodies - pharmacology | Acquired Immunodeficiency Syndrome - transmission | Protein Structure, Secondary | Antibodies, Monoclonal - pharmacology | Cells, Cultured | Antibodies, Neutralizing - pharmacology | Antibodies, Neutralizing - genetics | Transcytosis - immunology | Epitopes - genetics | HIV-1 - genetics | Antibodies, Monoclonal - genetics | HIV-1 - immunology | Immunoglobulin G - genetics | Transcytosis - drug effects | Antibodies, Monoclonal - metabolism | HIV Antibodies - genetics | Viral antibodies | Antiviral agents | Physiological aspects | Research | Health aspects | Protein binding | Life Sciences | Biological Sciences
Journal Article
AIDS, ISSN 0269-9370, 06/2013, Volume 27, Issue 9, pp. F13 - F20
Journal Article
Journal Article
Advances in Pharmacology, ISSN 1054-3589, 2014, Volume 71, pp. 147 - 163
Journal Article
Neuron, ISSN 0896-6273, 03/2017, Volume 93, Issue 6, pp. 1325 - 1333.e3
Blood-central nervous system (CNS) barriers partition neural tissues from the blood, providing a homeostatic environment for proper neural function. The... 
blood-CNS barrier | blood-brain barrier | Mfsd2a | Cav-1 | blood-retinal barrier | endothelial cells | pericytes | transcytosis | tight junctions | retinal vasculature | BRAIN-BARRIER | VASCULAR DEVELOPMENT | MAINTENANCE | ANGIOGENESIS | ENDOTHELIAL-CELLS | CNS | MICE | DIFFERENTIATION | DYSFUNCTION | NEUROSCIENCES | PERICYTES | Blood-Retinal Barrier - ultrastructure | Transcytosis - physiology | Tight Junctions - genetics | Transcytosis - genetics | Caveolin 1 - genetics | Male | Blood-Retinal Barrier - growth & development | Membrane Transport Proteins - physiology | Mice, Knockout | Membrane Transport Proteins - biosynthesis | Tight Junctions - physiology | Animals | Membrane Transport Proteins - genetics | Female | Mice | Caveolin 1 - physiology | Endothelial Cells - physiology | Permeability | Neovascularization | Neurophysiology | Endothelium | Spinal cord | Neuroglia | Central nervous system | Disorders | Homeostasis | Retina | Nervous system | Drug delivery | Transplantation | Angiogenesis | Blood-brain barrier | Neurodegeneration | Degeneration | Chimeras | Vascular endothelial growth factor | Catenin | Assembly | Age | Leakage | Head | Optic nerve | Tight junctions | Neurodegenerative diseases | Vessels | Blood vessels | Biotin | Sun | Endothelial cells | Dextran | Properties (attributes) | Phototransduction | Blood circulation | Hypoxia | Adults | Glia | Differentiation | Budding | Tracers
Journal Article
Journal of Neurochemistry, ISSN 0022-3042, 03/2001, Volume 76, Issue 5, pp. 1597 - 1600
The brain efflux index method is used to examine the extent to which transferrin effluxes from brain to blood across the blood-brain barrier (BBB) following... 
transcytosis
Journal Article