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Proceedings of the National Academy of Sciences, ISSN 0027-8424, 02/2010, Volume 107, Issue 5, pp. 2319 - 2324
Journal Article
Nature Chemical Biology, ISSN 1552-4450, 07/2015, Volume 11, Issue 7, pp. 511 - 517
Journal Article
Nature, ISSN 0028-0836, 10/2011, Volume 478, Issue 7367, pp. 123 - 126
Spinal muscular atrophy (SMA) is a motor neuron disease and the leading genetic cause of infant mortality; it results from loss-of-function mutations in the... 
SURVIVAL | IGF-I | DISEASES | MULTIDISCIPLINARY SCIENCES | GROWTH | PHENOTYPE | MICE | CARDIAC DEFECTS | DELIVERY | Spinal Cord - metabolism | Longevity - drug effects | Humans | Glycoproteins - metabolism | RNA, Messenger - analysis | Survival of Motor Neuron 2 Protein - metabolism | Motor Neurons - pathology | Muscular Atrophy, Spinal - genetics | Spinal Cord - pathology | Survival of Motor Neuron 2 Protein - genetics | Survival of Motor Neuron 1 Protein - genetics | RNA Isoforms - analysis | Glycoproteins - deficiency | Spinal Cord - cytology | Transgenes | Muscular Atrophy, Spinal - physiopathology | Motor Neurons - drug effects | Disease Models, Animal | Animals, Newborn | Muscular Atrophy, Spinal - metabolism | Oligonucleotides, Antisense - pharmacology | RNA Isoforms - genetics | Growth Hormone - metabolism | Alternative Splicing - genetics | Liver - metabolism | RNA, Messenger - genetics | Kaplan-Meier Estimate | Insulin-Like Growth Factor I - deficiency | Mice, Transgenic | Muscular Atrophy, Spinal - pathology | Motor Neurons - metabolism | Rotarod Performance Test | Alternative Splicing - drug effects | Animals | Carrier Proteins - metabolism | Oligonucleotides, Antisense - genetics | Oligonucleotides, Antisense - administration & dosage | Mice | Insulin-Like Growth Factor I - metabolism | Complications and side effects | Care and treatment | Gene mutations | Patient outcomes | Genetic aspects | Infants | Research | Diagnosis | Risk factors | Spinal muscular atrophy | Gene expression | Medical research | Rodents
Journal Article
PLoS Pathogens, ISSN 1553-7366, 07/2013, Volume 9, Issue 7, p. e1003490
The intrahepatic immune environment is normally biased towards tolerance. Nonetheless, effective antiviral immune responses can be induced against hepatotropic... 
HEPATITIS-B-VIRUS | DENDRITIC CELLS | MICROBIOLOGY | CHRONIC VIRAL-INFECTION | PERSISTENCE IN-VIVO | LIVER TOLERANCE | VIROLOGY | EXOGENOUS ANTIGEN | ANTIGEN-PRESENTING CELLS | SINUSOIDAL-ENDOTHELIAL-CELLS | PARASITOLOGY | TRANSGENIC MICE | CROSS-PRESENTATION | Liver - virology | Liver - pathology | Antigens, Viral - metabolism | CD8-Positive T-Lymphocytes - pathology | Cell Proliferation | Hepatitis B - metabolism | Dendritic Cells - immunology | Hepatitis B - virology | Dendritic Cells - pathology | Male | T-Lymphocytes, Cytotoxic - pathology | Hepatitis B - immunology | Liver - immunology | CD40 Antigens - metabolism | Antigen Presentation | CD8-Positive T-Lymphocytes - metabolism | Antigens, Differentiation - metabolism | CD40 Antigens - genetics | Cell Differentiation | Dendritic Cells - virology | Hepatitis B virus - immunology | Dendritic Cells - metabolism | Adaptive Immunity | T-Lymphocytes, Cytotoxic - immunology | Receptors, Antigen, T-Cell - metabolism | T-Lymphocytes, Cytotoxic - virology | Liver - metabolism | Mice, Inbred C57BL | Hepatitis B - pathology | Programmed Cell Death 1 Receptor - metabolism | Mice, Transgenic | CD40 Antigens - agonists | Hepatitis B virus - physiology | Mice, Knockout | Host-Pathogen Interactions | Animals | T-Lymphocytes, Cytotoxic - metabolism | CD8-Positive T-Lymphocytes - virology | Gene Expression Regulation, Viral | Antigens, Differentiation - genetics | Mice | Receptors, Antigen, T-Cell - genetics | CD8-Positive T-Lymphocytes - immunology | Programmed Cell Death 1 Receptor - genetics | Medical research | Hepatitis | T cell receptors | Immunology | Liver | Rodents
Journal Article
Journal Article
Journal Article
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 11/2016, Volume 100, pp. 153 - 163
There is increasing evidence for the involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of many of the major neurodegenerative... 
Neuroprotection | PPARγ agonists | Mitochondrial function | Neurodegenerative disorders | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | PROGRESSIVE PARKINSONS-DISEASE | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSIENT FOCAL ISCHEMIA | AMYOTROPHIC-LATERAL-SCLEROSIS | MODERATE ALZHEIMERS-DISEASE | PPAR gamma agonists | ENDOCRINOLOGY & METABOLISM | ACTIVATED-RECEPTOR-GAMMA | HUNTINGTIN-EXPRESSING CELLS | SPINAL-CORD-INJURY | NEUROBLASTOMA SH-SY5Y CELLS | TRANSGENIC MOUSE MODEL | Neuroprotective Agents - therapeutic use | Humans | Alzheimer Disease - drug therapy | Mitochondria - metabolism | Parkinson Disease - drug therapy | Mitochondria - drug effects | Neurodegenerative Diseases - metabolism | Neurodegenerative Diseases - drug therapy | Huntington Disease - metabolism | Amyotrophic Lateral Sclerosis - drug therapy | PPAR gamma - pharmacology | PPAR gamma - therapeutic use | Animals | Neurodegenerative Diseases - physiopathology | Neuroprotective Agents - pharmacology | Alzheimer Disease - metabolism | Amyotrophic Lateral Sclerosis - metabolism | Parkinson Disease - metabolism | Huntington Disease - drug therapy | Mitochondria - physiology | Disease Models, Animal | GSK-3β, glycogen synthase kinase-3β | BDNF, brain derived neurotrophic factor | SRC, steroid receptor coactivator | Aβ, protein amyloid-β | UCP-2, uncoupling protein 2 | Bcl-2, B-cell lymphoma2 | Review | Nrf2, nuclear factor erythroid-derived 2-like 2 | ALS, amyotrophic lateral sclerosis | HD, huntington's disease | NRF1, nuclear respiratory factor 1 | AF-1, transcriptional activation domain | LPS, lipopolysacchacaride | PPARγ, peroxisome proliferation-activated receptor gamma | UCP-1, uncoupling protein 1 | mtDNA, mitochondrial DNA | ROS, reactive oxygen species | TNFα, tumour necrosis factor α | PD, parkinson's disease | TDP-43, TAR DNA-binding protein 43 | Cdk5, cyclin-dependent kinase 5 | COX-2, cyclooxygenase-2 | PGC1α, peroxisome proliferator-activated receptor gamma coactivator 1α | SOD1, superoxide dismutase 1 | HO-1, haem oxygenase-1 | BAT, brown adipose tissue | AD, alzheimer's disease | Bax, Bcl-2-associated X protein | TZDs, thiazolidinediones | ΔΨm, mitochondrial membrane potential | 15D-PGJ2, 15-deoxy-Δ12,14-Prostaglandin J2 | MPTP, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine | CBP, CREB-binding protein | CNS, central nervous system | WAT, white adipose tissue | 6-OHDA, 6-hydroxydopamine | NF-κB, nuclear factor-κB | iNOS, inducible nitric oxide synthase | TFAM, mitochondrial transcription factor A | MPP+, 1-methyl-4-phenylpyridinium ion | NRF2, nuclear respiratory factor 2
Journal Article