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Biochemical Journal, ISSN 0264-6021, 03/2014, Volume 458, Issue 3, pp. 559 - 573
Precise homoeostasis of the intracellular concentration of Cl- is achieved via the co-ordinated activities of the Cl- influx and efflux. We demonstrate that... 
Signal transduction | co-transporter 1 (NKCC1) | co-transporter (NCC) | Protein kinase | γ-aminobutyric acid (GABA) | Cl | Blood pressure/hypertension | 2Cl | co-transporter 2 (KCC2) | Ion homoeostasis | co-transporter 3 (KCC3) | SALT TRANSPORT | CELL-VOLUME | signal transduction | CATION-CHLORIDE COTRANSPORTERS | ION-TRANSPORT | BIOCHEMISTRY & MOLECULAR BIOLOGY | blood pressure/hypertension | ion homoeostasis | HYPOKALEMIC ALKALOSIS | K+-Cl- co-transporter 3 (KCC3) | Na+-K+-2Cl(-) co-transporter 1 (NKCC1) | K+-Cl- co-transporter 2 (KCC2) | protein kinase | BLOOD-PRESSURE | PROTEIN-KINASES | BARTTERS-SYNDROME | Na+-Cl- co-transporter (NCC) | ALANINE-RICH KINASE | MOLECULAR PHYSIOLOGY | gamma-aminobutyric acid (GABA) | N[K]CC, Na+–K+ ion co-transporter | HEK, human embryonic kidney | TTBS, Tris-buffered saline containing Tween 20 | HRP, horseradish peroxidase | ES, embryonic stem | Na+–Cl− co-transporter (NCC) | CCT, conserved C-terminal | NCC, Na+–Cl− co-transporter | Na+–K+–2Cl− co-transporter 1 (NKCC1) | OSR1, oxidative stress-responsive kinase 1 | CCC, cation–Cl− co-transporter | K+–Cl− co-transporter 3 (KCC3) | KCC, K+–Cl− co-transporter | blood pressure | ERK1, extracellular-signal-regulated kinase 1 | SLC12, solute carrier family 12 | LDS, lithium dodecyl sulfate | NKCC, Na+–K+–2Cl− co-transporter | SPAK, SPS1-related proline | NTD, N-terminal cytoplasmic domain | WNK, WNK lysine-deficient protein kinase | CTD, C-terminal cytoplasmic domain | hypertension | XIC, extracted ion chromatogram | K+–Cl− co-transporter 2 (KCC2) | alanine-rich kinase
Journal Article
Lipids in health and disease, ISSN 1476-511X, 2019, Volume 18, Issue 1, pp. 2 - 7
Background: ATP-binding cassette (ABC) transporters are involved in a huge range of physiological processes. Mutations in the ABCC6 gene cause pseudoxanthoma... 
ATP-binding cassette transporters | NUTRITION & DIETETICS | BIOCHEMISTRY & MOLECULAR BIOLOGY | Abcc6 | MOUSE | Pseudoxanthoma elasticum | Mice | MUTATIONS | SECRETION | Gene expression | PCR | Liver - pathology | Kidney - pathology | Lipoproteins - genetics | Adipose Tissue, White - metabolism | Male | ATP Binding Cassette Transporter, Subfamily G, Member 1 - metabolism | ATP-Binding Cassette Transporters - deficiency | Kidney - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 1 - genetics | ATP-Binding Cassette Transporters - genetics | Biological Transport | ATP Binding Cassette Transporter, Subfamily G, Member 8 - metabolism | Lipoproteins - metabolism | ATP-Binding Cassette Transporters - metabolism | Female | ATP Binding Cassette Transporter, Subfamily B - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 8 - genetics | ATP Binding Cassette Transporter, Subfamily G, Member 5 - metabolism | Disease Models, Animal | ATP Binding Cassette Transporter, Subfamily B, Member 11 - metabolism | ATP Binding Cassette Transporter, Subfamily G, Member 5 - genetics | Adipose Tissue, White - pathology | Pseudoxanthoma Elasticum - metabolism | Liver - metabolism | Gene Expression Regulation | Bile Acids and Salts - metabolism | Pseudoxanthoma Elasticum - pathology | Cholesterol - metabolism | ATP Binding Cassette Transporter, Subfamily B - metabolism | Disease Progression | Mice, Knockout | ATP Binding Cassette Transporter, Subfamily B, Member 11 - genetics | ATP Binding Cassette Transporter, Subfamily D - genetics | Animals | ATP Binding Cassette Transporter, Subfamily D - metabolism | Pseudoxanthoma Elasticum - genetics | Research | Tissues | Adenosine triphosphate | Calcification (ectopic) | Adipose tissue | Disease | Gene regulation | Liver | Homeostasis | Lipids | Phospholipids | ABCA1 protein | Sterols | Metabolites | Mineralization | Rodents | Fibroblasts | Physiology | ABC transporters | Lipid metabolism | Age | Kidneys | Metabolism | Cholesterol | Lipoproteins | Calcification | ATP-binding protein | Mutation | ABC transporter | Bile
Journal Article
Journal Article
Acta Pharmaceutica Sinica B, ISSN 2211-3835, 05/2017, Volume 7, Issue 3, pp. 260 - 280
Oral drug absorption is a process influenced by the physicochemical and biopharmaceutical properties of the drug and its inter-relationship with the... 
Formulation strategies | Factors affecting absorption | BCS | Permeability | Solubility | FORMULATION DEVELOPMENT | Formulations strategies | SOLID DISPERSION | BIORELEVANT DISSOLUTION MEDIA | POLYMERIC MICELLES | DRUG-DELIVERY-SYSTEMS | EQUILIBRIUM SOLUBILITY | MESOPOROUS SILICON MICROPARTICLES | NANOSTRUCTURED LIPID CARRIERS | ORAL BIOAVAILABILITY | PHARMACOLOGY & PHARMACY | IN-VIVO EVALUATION | AZT, azidothymidine | PEG, polyethylene glycol | P-gp, P-glycoprotein | MCT, monocarboxylate transporter | VDAD, volume to dissolve applied dose | OMM, ordered mesoporous material | vit. E TPGS, vitamin E tocopherol polyethylene glycol succinate | SLC, solute carrier | ABC, ATP-binding cassette | GRAS, generally recognized as safe | BE, bioavailability | SPIP, single pass intestinal perfusion | OAT, organic anion transporter | NLC, nanostructured lipid carrier | GIS, gastrointestinal simulator | IR, immediate release | PAMPA, parallel artificial membrane permeability assay | SGLT, sodium dependent secondary active transporter | AP, absorption potential | SDS, sodium dodecyl sulphate | CD, cyclodextrin | SIF, simulated intestinal fluid | bioequivalence | FDA, U.S. Food and Drug Administration | RFC, reduced folate transporter | BSP, bromosulfophthalein | Psi, porous silicon | FeSSIF, fed state simulated intestinal fluid | FaSSIF, fasted state simulated intestinal fluid | Peff, effective permeability | EMEA, European Medicines Agency | OCTN, organic cationic | CNT, concentrative nucleoside transporter | PAH, p-aminohippurate | carnitine transporter | OATP, organic anion transporting polypeptide | D:S, dose:solubility | BCRP, breast cancer resistance protein | OCT, organic cationic transporter | MPP, 1-methyl-4-phenylpyridinium | MRP, multidrug resistance associated protein | SLCO, solute carrier organic anion | SMVT, sodium dependent multivitamin transporter | ISBT, sodium dependent bile salt transporter | TEOS, tetraethylortho silicate | Review | CNT, Na+-dependent concentrative transporter | UWL, unstirred water layer | E217G, estradiol 17β-glucuronide | PMAT, plasma membrane monoamine transport | IDR, intrinsic dissolution rate | PVDF, polyvinylidene difluoride | SVCT, sodium-dependent vitamin C transporter | HPC-SL, LBDDS, lipid based drug delivery system | WHO, World Health Organization | ATP, adenosine triphosphate | BCS, biopharmaceutical classification system | CYP, cytochrome P450 | HIV, human immunodeficiency disease | FIP, International Pharmaceutical Federation | GLUT, sodium-independent facilitated diffusion transporter | PSA, polar surface area | NTCP, sodium-dependent taurocholate co-transporting polypeptide | ENT, equilibrative nucleoside transporter | GITA, gastrointestinal transit and absorption | HUGO, Human Genome Organization | PGA, polyglycolic acid | NME, new molecular entity | API, active pharmaceutical ingredient | PLA, poly(lactic acid) | BDDS, biopharmaceutical drug disposition system | GIT, gastrointestinal tract | Papp, apparent permeability | PLGA, poly-d,l-lactide-co-glycoside | PEPT, peptide transporter | pMMA, polymethyl methacrylate | SUPAC, scale-up and post approval changes | CDER, Centre for Drug Evaluation and Research | PEI, polyethyleneimine | FATP, fatty acid transporter protein | ICH, International Council of Harmonization | SLN, solid lipid nanoparticles
Journal Article
Biochemical journal, ISSN 1470-8728, 2013, Volume 451, Issue 1, pp. 111 - 122
The WNK (with no lysine kinase)–SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1) signalling pathway plays an... 
Ubiquitin | Cullin-RING E3 ligase (CRL) | SPS1-related proline/alanine-rich kinase/oxidative stress-responsive kinase 1 (SPAK/OSR1) | co-transporter (NCC) | co-transporter 2 (NKCC2) | BTB domain | Cl | 2Cl | Kelch-like domain (KLHL domain) | SPAK | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | Na+/K+/2Cl(-) co-transporter 2 (NKCC2) | ubiquitin | BLOOD-PRESSURE | DOMINANT RETINITIS-PIGMENTOSA | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | PSEUDOHYPOALDOSTERONISM TYPE-II | ADAPTER | BTB-KELCH PROTEINS | RING UBIQUITIN LIGASES | KINASES | Minor Histocompatibility Antigens | Pseudohypoaldosteronism - genetics | Humans | Protein-Serine-Threonine Kinases - genetics | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Mutation, Missense | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Cullin Proteins - genetics | Transcription Factors - metabolism | Carrier Proteins - genetics | Pseudohypoaldosteronism - enzymology | Ubiquitination | Carrier Proteins - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | HEK293 Cells | Cullin Proteins - metabolism | HeLa Cells | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | Amino Acid Substitution | HEK, human embryonic kidney | 2Cl− co-transporter | RT, reverse transcription | TTBS, Tris-buffered saline containing Tween 20 | DTT, dithiothreitol | rTEV, recombinant tobacco etch virus | HRP, horseradish peroxidase | LC, liquid chromatography | UBE2D3, ubiquitin-conjugating enzyme E2 D3 | qRT-PCR, real time quantitative reverse transcription PCR | TAL, thick ascending limb | OSR1, oxidative stress-responsive kinase 1 | GST, glutathione transferase | RBX1, RING-box 1, E3 ubiquitin protein ligase | 2Cl− co-transporter 2 (NKCC2) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase | UBE1, ubiquitin-like modifier-activating enzyme 1 | Cullin–RING E3 ligase (CRL) | GFP, green fluorescent protein | Cl− co-transporter | NKCC, Na+ | DCT, distal convoluted tubule | KEAP1, Kelch-like ECH-associated protein 1 | CRL, Cullin–RING E3 ligase | SPAK, SPS1-related proline | Accelerated Publication | Cl− co-transporter (NCC) | siRNA, small interfering RNA | NRF2, NF-E2-related factor 2 | oxidative stress-responsive kinase 1 (SPAK | WNK, with no lysine kinase | RPL13A, ribosomal protein L13a | KLHL3, Kelch-like 3 | CUL3, Cullin-3 | Na+ | SPS1-related proline | NCC, Na+ | alanine-rich kinase
Journal Article
Biochemical Journal, ISSN 0264-6021, 01/2012, Volume 441, Issue 1, pp. 325 - 337
Mutations in the WNK with no lysine (K) kinase] family instigate hypertension and pain perception disorders. Of the four WNK isoforms, much of the focus has... 
Signal transduction | co-transporter 1 (NKCC1) | co-transporter (NCC) | Protein kinase | Cl | 2Cl | Coiled-coil domain | Osmotic stress | KINASE-ACTIVITY | SPAK | coiled-coil domain | HOMEOSTASIS | Na+/K+/2Cl(-) co-transporter 1 (NKCC1) | signal transduction | PHOSPHORYLATION | PROTEIN-KINASE | OSR1 | BIOCHEMISTRY & MOLECULAR BIOLOGY | protein kinase | BLOOD-PRESSURE | osmotic stress | Na+/Cl- co-transporter (NCC) | NA+-CL-COTRANSPORTER | MUTATIONS | HYPERTENSION | Protein Structure, Tertiary | Amino Acid Sequence | Phosphorylation | Minor Histocompatibility Antigens | Humans | Gene Expression Regulation | Protein-Serine-Threonine Kinases - genetics | Molecular Sequence Data | Sodium-Potassium-Chloride Symporters - genetics | Intracellular Signaling Peptides and Proteins - metabolism | Transcription Factors - genetics | Sodium-Potassium-Chloride Symporters - metabolism | Transcription Factors - metabolism | Solute Carrier Family 12, Member 2 | WNK Lysine-Deficient Protein Kinase 1 | Protein Isoforms | HEK293 Cells | Embryonic Stem Cells | Mutation | Intracellular Signaling Peptides and Proteins - genetics | Protein-Serine-Threonine Kinases - metabolism | CCD, coiled-coil domain | PI3K, phosphoinositide 3-kinase | WNK, with no lysine (K) kinase | 2Cl− co-transporter | DTT, dithiothreitol | ERK, extracellular-signal-regulated kinase | ES, embryonic stem | DMEM, Dulbecco's modified Eagle's medium | CCT, conserved C-terminal | GST, glutathione transferase | HEK-293, human embryonic kidney 293 | 2Cl− co-transporter 1 (NKCC1) | Cl− co-transporter | NKCC, Na+ | SPAK, SPS1-related proline | Cl− co-transporter (NCC) | OSR, oxidative stress-responsive kinase | LRRK2, leucine-repeat-rich kinase 2 | CATCHtide, cation chloride co-transporter peptide substrate | Na+ | NCC, Na+ | MAPK, mitogen-activated protein kinase | alanine-rich kinase
Journal Article
Circulation Research, ISSN 0009-7330, 03/2015, Volume 116, Issue 7, pp. 1133 - 1142
Journal Article