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1. Full Text A Phase II study of the efficacy and safety of rontalizumab (rhuMAb interferon-α) in patients with systemic lupus erythematosus (ROSE)
by Kalunian, Kenneth C and Merrill, Joan T and Maciuca, Romeo and McBride, Jacqueline M and Townsend, Michael J and Wei, Xiaohui and Davis, John C and Kennedy, William P
Annals of the Rheumatic Diseases, ISSN 0003-4967, 01/2016, Volume 75, Issue 1, pp. 196 - 202
ObjectivesTo examine the safety and efficacy of rontalizumab, a humanised IgG1 anti-interferon α (anti-IFN-α) monoclonal antibody, in patients with... 
DEFINITION | THERAPY | FLARES | CLASSIFICATION | INDEX | RHEUMATOLOGY | DISEASE-ACTIVITY | Severity of Illness Index | Antibodies, Monoclonal, Humanized - adverse effects | Glucocorticoids - administration & dosage | Antibodies, Monoclonal, Humanized - therapeutic use | Injections, Intravenous | Double-Blind Method | Drug Administration Schedule | Humans | Middle Aged | Immunologic Factors - administration & dosage | Male | Treatment Outcome | Biomarkers - blood | Antibodies, Monoclonal, Humanized - administration & dosage | Injections, Subcutaneous | Lupus Erythematosus, Systemic - drug therapy | Lupus Erythematosus, Systemic - immunology | Adult | Female | Immunologic Factors - adverse effects | Drug Therapy, Combination | Immunologic Factors - therapeutic use | Monoclonal antibodies | Care and treatment | Systemic lupus erythematosus | Research | Health aspects | Interferon alpha | Index Medicus
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2. Full Text Antianginal Efficacy of Ranolazine When Added to Treatment With Amlodipine. The ERICA (Efficacy of Ranolazine in Chronic Angina) Trial
by Stone, Peter H and Gratsiansky, Nikolay A and Blokhin, Alexey and Huang, I-Zu and Meng, Lixin and ERICA Investigators
Journal of the American College of Cardiology, ISSN 0735-1097, 08/2006, Volume 48, Issue 3, pp. 566 - 575
Objectives: The purpose of this study was to determine if ranolazine improves angina in stable coronary patients with persisting symptoms despite maximum... 
ATENOLOL | DRUG-THERAPY | CARDIAC & CARDIOVASCULAR SYSTEMS | CHRONIC STABLE ANGINA | PECTORIS | FELODIPINE | DILTIAZEM | EXERCISE TOLERANCE | METOPROLOL | BETA-BLOCKERS | BLOCKADE | Double-Blind Method | Vasodilator Agents - therapeutic use | Angina Pectoris - prevention & control | Humans | Middle Aged | Nitroglycerin - therapeutic use | Male | Treatment Outcome | Piperazines - therapeutic use | Amlodipine - therapeutic use | Incidence | Ranolazine | Nitroglycerin - administration & dosage | Coronary Disease - drug therapy | Angina Pectoris - epidemiology | Female | Aged | Drug Therapy, Combination | Acetanilides | Chronic Disease | Vasodilator Agents - administration & dosage | Heart | Heart rate | Heart attacks | Coronary vessels | Fitness equipment | Drug therapy | Drug dosages | Chronic illnesses | Index Medicus | Abridged Index Medicus
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3. Full Text The safety and efficacy of ±3,4-methylenedioxymethamphetamine-assisted psychotherapy in subjects with chronic, treatment-resistant posttraumatic stress disorder: the first randomized controlled pilot study
by Mithoefer, Michael C and Wagner, Mark T and Mithoefer, Ann T and Jerome, Lisa and Doblin, Rick
Journal of Psychopharmacology, ISSN 0269-8811, 4/2011, Volume 25, Issue 4, pp. 439 - 452
Case reports indicate that psychiatrists administered ±3,4-methylenedioxymethamphetamine (MDMA) as a catalyst to psychotherapy before recreational use of MDMA... 
psychedelics | PTSD | Posttraumatic stress disorder | combat disorders | MDMA | RISK-FACTORS | SERTRALINE | PSYCHIATRY | PREVALENCE | NEURAL CIRCUITRY | PHARMACOTHERAPY | NEUROSCIENCES | CLINICAL NEUROLOGY | PHARMACOKINETICS | AFGHANISTAN | MDMA ECSTASY | OXYTOCIN | PHARMACOLOGY & PHARMACY | EXPOSURE | Serotonin Agents - therapeutic use | Double-Blind Method | Humans | Middle Aged | N-Methyl-3,4-methylenedioxyamphetamine - adverse effects | N-Methyl-3,4-methylenedioxyamphetamine - therapeutic use | Fear - drug effects | Psychotherapy | Male | Treatment Outcome | Stress Disorders, Post-Traumatic - psychology | Serotonin Agents - adverse effects | Cross-Over Studies | Stress Disorders, Post-Traumatic - therapy | Young Adult | Pilot Projects | Psychiatric Status Rating Scales | Stress Disorders, Post-Traumatic - drug therapy | Music Therapy | Fear - psychology | Placebos | Adult | Female | Aged | Psychological aspects | Care and treatment | Patient outcomes | Ecstasy (Drug) | Post-traumatic stress disorder | Dosage and administration | Research | Health aspects | Stresses | Temperature | Effectiveness | Catalysts | Medical services | Case reports | Cognition | Patients | Blood | Stress | Recreational use | Temperature effects | Psychopharmacology | Blood pressure | Safety | Monitoring | Ecstasy | Studies | Post traumatic stress disorder | Medical treatment | Experimental psychology | Treatment Effectiveness | Survivors | Adults | Hallucinogenic Drugs | Negative Therapeutic Reaction | Manual-Based Treatments | Stressors | Randomized Clinical Trial | Index Medicus | Original Papers
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4. Full Text FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P₁) modulation
by Ji Woong Choi and Shannon E. Gardell and Deron R. Herr and Richard Rivera and Chang-Wook Lee and Kyoko Noguchi and Siew Teng Teo and Yun C. Yung and Melissa Lu and Grace Kennedy and Jerold Chun and Michael Sela
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 1/2011, Volume 108, Issue 2, pp. 751 - 756
Sphingosine 1-phosphate (S1P), a lysophospholipid, has gained relevance to multiple sclerosis through the discovery of FTY720 (fingolimod), recently approved... 
Receptors | Multiple sclerosis | Spinal cord | Astrocytes | Neurons | Lymphocytes | Central nervous system | Cell lines | Null condition | Mice | G protein-coupled receptor | Lysophospholipid | Neuroprotection | Knockout | knockout | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | ACTIVATION | ORAL FINGOLIMOD | WHITE-MATTER | MULTIDISCIPLINARY SCIENCES | LYMPHOCYTE EGRESS | AGONISTS | neuroprotection | FIBRILLARY ACIDIC PROTEIN | SPHINGOSINE-1-PHOSPHATE | IMMUNOSUPPRESSANT FTY720 | CENTRAL-NERVOUS-SYSTEM | lysophospholipid | Astrocytes - cytology | Lymphocytes - metabolism | Propylene Glycols - pharmacology | Encephalomyelitis, Autoimmune, Experimental - metabolism | Receptors, G-Protein-Coupled - metabolism | Signal Transduction | Encephalomyelitis, Autoimmune, Experimental - drug therapy | Mice, Inbred C57BL | Gene Expression Regulation | Fingolimod Hydrochloride | Mice, Knockout | Sphingosine - pharmacology | Sphingosine - analogs & derivatives | Animals | Female | Receptors, Lysosphingolipid - metabolism | Immunosuppressive Agents - pharmacology | Disease Models, Animal | Multiple Sclerosis - drug therapy | Physiological aspects | Care and treatment | Studies | Prescription drugs | Phosphorylation | Immunology | Metabolites | Rodents | Lipids | Models | Gene expression | Index Medicus | Animal models | Cell lineage | Data processing | Neuromodulation | Experimental allergic encephalomyelitis | sphingosine 1-phosphate receptors | Sphingosine 1-phosphate | Signal transduction | Gliosis | Demyelination | FTY720 | Glia | Protein transport | Biological Sciences
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5. Full Text Efficacy and safety of exenatide once weekly versus metformin, pioglitazone, and sitagliptin used as monotherapy in drug-naive patients with type 2 diabetes (DURATION-4): A 26-week double-blind study
by Russell-Jones, David and Cuddihy, Robert M and Hanefeld, Markolf and Kumar, Ajay and González, Jose G and Chan, Melanie and Wolka, Anne M and Boardman, Marilyn K and DURATION-4 Study Grp and DURATION-4 Study Group and on behalf of the DURATION-4 Study Group
Diabetes Care, ISSN 0149-5992, 02/2012, Volume 35, Issue 2, pp. 252 - 258
OBJECTIVE-To test the safety and efficacy of exenatide once weekly (EQW) compared with metformin (MET), pioglitazone (PIO), and sitagliptin (SITA) over 26... 
GLICLAZIDE | GLYCEMIC CONTROL | INITIAL COMBINATION THERAPY | VILDAGLIPTIN | TOLERABILITY | PARALLEL-GROUP | ENDOCRINOLOGY & METABOLISM | RANDOMIZED-TRIAL | OPEN-LABEL | MELLITUS | INSULIN SENSITIVITY | Hypoglycemic Agents - therapeutic use | Triazoles - administration & dosage | Metformin - therapeutic use | Double-Blind Method | Drug Administration Schedule | Humans | Middle Aged | Pyrazines - administration & dosage | Male | Treatment Outcome | Pyrazines - therapeutic use | Thiazolidinediones - administration & dosage | Peptides - administration & dosage | Thiazolidinediones - therapeutic use | Hypoglycemic Agents - administration & dosage | Venoms - therapeutic use | Venoms - administration & dosage | Female | Metformin - administration & dosage | Sitagliptin Phosphate | Diabetes Mellitus, Type 2 - drug therapy | Peptides - therapeutic use | Triazoles - therapeutic use | Type 2 diabetes | Diabetics | Care and treatment | Hypoglycemic agents | Research | Diabetes | Pharmaceutical industry | Algorithms | Consciousness | Education | Clinical trials | Drug dosages | Pharmaceuticals | Index Medicus | Original Research
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6. Full Text Efficacy and long-term safety of alipogene tiparvovec (AAV1-LPL S447X) gene therapy for lipoprotein lipase deficiency: An open-label trial
by Gaudet, D and Méthot, J and Déry, S and Brisson, D and Essiembre, C and Tremblay, G and Tremblay, K and De Wal, J and Twisk, J and Van Den Bulk, N and Sier-Ferreira, V and Van Deventer, S
Gene Therapy, ISSN 0969-7128, 04/2013, Volume 20, Issue 4, pp. 361 - 369
We describe the 2-year follow-up of an open-label trial (CT-AMT-011-01) of AAV1-LPLS447X gene therapy for lipoprotein lipase (LPL) deficiency (LPLD), an orphan... 
alipogene tiparvovec | familial chylomicronemia | LPL deficiency | AAV1-LPL | MEDICINE, RESEARCH & EXPERIMENTAL | ACTIVATION | CLINICAL-TRIAL | BIOCHEMISTRY & MOLECULAR BIOLOGY | CHYLOMICRONEMIA SYNDROME | AAV1-LPLS447X | PATHOGENESIS | SKELETAL-MUSCLE | METABOLISM | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | BENEFICIAL MUTATION | DISEASE | GENETICS & HEREDITY | ACUTE-PANCREATITIS | EXPRESSION | Dependovirus - genetics | Genetic Therapy | Hyperlipoproteinemia Type I - complications | Prospective Studies | Lipoprotein Lipase - genetics | Humans | Immunosuppressive Agents - therapeutic use | Middle Aged | Drug Tolerance | Male | Treatment Outcome | Pancreatitis - complications | Fasting - blood | Triglycerides - blood | Adult | Female | Hyperlipoproteinemia Type I - therapy | Lipoprotein Lipase - metabolism | Immunosuppressive Agents - administration & dosage | Safety and security measures | Gene mutations | Physiological aspects | Lipoprotein lipase | Research | Gene therapy | Health aspects | Lipids | Genetic disorders | Metabolism | Index Medicus | gene therapy
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7. Full Text Safety and efficacy of everolimus- versus sirolimus-eluting stents 5-year results from SORT OUT IV
by Jensen, Lisette Okkels and Thayssen, Per and Christiansen, Evald Høj and Maeng, Michael and Ravkilde, Jan and Hansen, Knud Nørregaard and Hansen, Henrik Steen and Krusell, Lars and Kaltoft, Anne and Tilsted, Hans Henrik and Berencsi, Klara and Junker, Anders and Lassen, Jens Flensted and SORT OUT IV Investigators
Journal of the American College of Cardiology, ISSN 0735-1097, 02/2016, Volume 67, Issue 7, pp. 751 - 762
Background Long-term safety and efficacy for everolimus-eluting stents (EES) versus those of sirolimus-eluting stents (SES) are unknown. Objectives This study... 
very late definite stent thrombosis | percutaneous coronary intervention | outcome | drug-eluting stent(s) | BIODEGRADABLE POLYMER | CARDIAC & CARDIOVASCULAR SYSTEMS | NON-INFERIORITY TRIAL | FOLLOW-UP | RANDOMIZED CONTROLLED-TRIAL | PACLITAXEL | TERM CLINICAL-OUTCOMES | UNSELECTED PATIENTS | SUPERIORITY TRIAL | DURABLE POLYMER | CORONARY-ARTERY-DISEASE | Single-Blind Method | Coronary Artery Disease - surgery | Drug-Eluting Stents | Survival Rate - trends | Everolimus - pharmacology | Follow-Up Studies | Humans | Middle Aged | Kaplan-Meier Estimate | Male | Treatment Outcome | Postoperative Complications - epidemiology | Prosthesis Design | Sirolimus - pharmacology | Incidence | Time Factors | Percutaneous Coronary Intervention - methods | Denmark - epidemiology | Female | Retrospective Studies | Immunosuppressive Agents - pharmacology | Studies | Confidence intervals | Heart attacks | Medical imaging | Coronary vessels | Mortality | Cardiovascular disease | Acute coronary syndromes | Stents | Thrombosis | Clinical outcomes | Index Medicus | Abridged Index Medicus
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8. Full Text Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
by Routy, Bertrand and Le Chatelier, Emmanuelle and Derosa, Lisa and Duong, Connie P.M and Alou, Maryam Tidjani and Daillère, Romain and Fluckiger, Aurélie and Messaoudene, Meriem and Rauber, Conrad and Roberti, Maria P and Fidelle, Marine and Flament, Caroline and Poirier-Colame, Vichnou and Opolon, Paule and Klein, Christophe and Iribarren, Kristina and Mondragón, Laura and Jacquelot, Nicolas and Qu, Bo and Ferrere, Gladys and Clémenson, Céline and Mezquita, Laura and Masip, Jordi Remon and Naltet, Charles and Brosseau, Solenn and Kaderbhai, Coureche and Richard, Corentin and Rizvi, Hira and Levenez, Florence and Galleron, Nathalie and Quinquis, Benoit and Pons, Nicolas and Ryffel, Bernhard and Minard-Colin, Véronique and Gonin, Patrick and Soria, Jean-Charles and Deutsch, Eric and Loriot, Yohann and Ghiringhelli, François and Zalcman, Gérard and Goldwasser, François and Escudier, Bernard and Hellmann, Matthew D and Eggermont, Alexander and Raoult, Didier and Albiges, Laurence and Kroemer, Guido and Zitvogel, Laurence
Science, ISSN 0036-8075, 01/2018, Volume 359, Issue 6371, pp. 91 - 97
Immune checkpoint inhibitors (ICIs) targeting the PD-1/PD-L1 axis induce sustained clinical responses in a sizable minority of cancer patients. We found that... 
CELL LUNG-CANCER | MELANOMA | MICROENVIRONMENT | INTESTINAL MICROBIOTA | CYCLOPHOSPHAMIDE | PD-1 BLOCKADE | MULTIDISCIPLINARY SCIENCES | GENES | RESISTANCE | ANTITUMOR IMMUNITY | NIVOLUMAB | CD4 Antigens - immunology | Immunotherapy - methods | Humans | Antibodies, Monoclonal - therapeutic use | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Gastrointestinal Microbiome - genetics | Fecal Microbiota Transplantation | Anti-Bacterial Agents - therapeutic use | Feces - microbiology | Metagenome - genetics | Neoplasms - therapy | Animals | Receptors, CCR - immunology | Interleukin-12 - immunology | Receptors, CXCR3 - immunology | T-Lymphocytes - immunology | Mice | Gastrointestinal Microbiome - immunology | Verrucomicrobia - genetics | Verrucomicrobia - immunology | Care and treatment | Cell receptors | Microbiota (Symbiotic organisms) | Immunotherapy | Epithelial tumors | Physiological aspects | Health aspects | Methods | Apoptosis | PD-1 protein | Lung | Interleukin | Microbiomes | Transplantation | Lymphocytes T | Anticancer properties | Microbiota | Lymphocytes | Bacteria | Feces | Supplementation | Gnotobiotics | Kidneys | Melanoma | Dietary supplements | Interleukin 12 | Abundance | CXCR3 protein | Patients | CD4 antigen | Immune checkpoint | Antibiotics | Flora | PD-L1 protein | Relative abundance | Antitumor activity | CCR9 protein | Tumors | Kidney transplantation | Cancer | Index Medicus | Life Sciences
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