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by Yan, CY and Wan, RX and Bai, R and Huang, GXY and Shi, YG
SCIENCE, ISSN 0036-8075, 08/2016, Volume 353, Issue 6302, pp. 904 - 911
Pre-messenger RNA (pre-mRNA) splicing is carried out by the spliceosome, which undergoes an intricate assembly and activation process. Here, we report an... 
METAL-ION CATALYSIS | 3-DIMENSIONAL STRUCTURE | GROUP-II INTRON | U4/U6.U5 TRI-SNRNP | MESSENGER-RNA | SMALL NUCLEAR-RNA | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | G-PATCH PROTEIN | CRYO-EM STRUCTURE
Journal Article
by Wan, RX and Yan, CY and Bai, R and Huang, GXY and Shi, YG
SCIENCE, ISSN 0036-8075, 08/2016, Volume 353, Issue 6302, pp. 895 - 904
Each cycle of pre-messenger RNA splicing, carried out by the spliceosome, comprises two sequential transesterification reactions, which result in the removal... 
METAL-ION CATALYSIS | 3-DIMENSIONAL STRUCTURE | 2ND STEP | U4/U6.U5 TRI-SNRNP | SMALL NUCLEAR-RNA | ACTIVE-SITE | CRYSTAL-STRUCTURE | MULTIDISCIPLINARY SCIENCES | ELECTRON-MICROSCOPY | 19 COMPLEX | CRYO-EM STRUCTURE
Journal Article
Cell, ISSN 0092-8674, 2009, Volume 136, Issue 4, pp. 701 - 718
Journal Article
COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, ISSN 1943-0264, 11/2019, Volume 11, Issue 11
The spliceosome is a highly complex, dynamic ribonucleoprotein molecular machine that undergoes numerous structural and compositional rearrangements that lead... 
HUMAN SPLICEOSOME | U4/U6.U5 TRI-SNRNP | PROTEIN | BRANCH SITE | MECHANISTIC INSIGHTS | MOLECULAR ARCHITECTURE | U2 SNRNP | STEP | PROTEOMIC ANALYSIS | ACTIVATED SPLICEOSOME | CELL BIOLOGY
Journal Article