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Current Opinion in Structural Biology, ISSN 0959-440X, 12/2016, Volume 41, pp. 194 - 202
Journal Article
Journal of the American Chemical Society, ISSN 0002-7863, 06/2016, Volume 138, Issue 24, pp. 7532 - 7535
The total synthesis of the spliceosome inhibitor thailanstatin A has been achieved in a longest linear sequence of nine steps from readily available starting... 
MICHAEL REACTION | SPLICEOSTATIN | CATALYSIS | U4/U6.U5 TRI-SNRNP | FR901464 | MECHANISM | BURKHOLDERIA SP | ALDEHYDES | INHIBITORS | CHEMISTRY, MULTIDISCIPLINARY | PRE-MESSENGER-RNA | Research | Chemical properties | Chemical synthesis | Hydrogenation | Statins
Journal Article
Trends in Biochemical Sciences, ISSN 0968-0004, 04/2018, Volume 43, Issue 4, pp. 237 - 250
RNA helicases are critical regulators at the nexus of multiple pathways of RNA metabolism, and in the complex cellular environment, tight spatial and temporal... 
protein cofactor | post-translational modification | ribonucleoprotein complex | RNA structure | gene expression | RNA helicase | PRP43 | COMPLEX | DOMAIN | ATPASE ACTIVITY | STRUCTURAL BASIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BOX ATPASE | FUNCTIONAL-ANALYSIS | G-PATCH PROTEIN | RIG-I | TRI-SNRNP
Journal Article
Nature, ISSN 0028-0836, 06/2017, Volume 546, Issue 7660, pp. 617 - 621
Intron removal requires assembly of the spliceosome on precursor mRNA (pre-mRNA) and extensive remodelling to form the spliceosome's catalytic centre. Here we... 
U4/U6.U5 TRI-SNRNP | COMPLEX | PROTEIN | MESSENGER-RNA | MULTIDISCIPLINARY SCIENCES | MOLECULAR ARCHITECTURE | U2 SNRNP | CRYO-EM STRUCTURE | REQUIRES ATP | RNA Helicases - metabolism | Ribonucleoprotein, U2 Small Nuclear - chemistry | Spliceosomes - chemistry | Saccharomyces cerevisiae - genetics | Ribonucleoprotein, U5 Small Nuclear - metabolism | RNA Splicing Factors - chemistry | RNA Helicases - chemistry | Ribonucleoprotein, U4-U6 Small Nuclear - metabolism | RNA Helicases - ultrastructure | RNA Splicing Factors - metabolism | Spliceosomes - metabolism | RNA Splicing | Ribonucleoprotein, U2 Small Nuclear - metabolism | Base Sequence | Protein Domains | RNA Precursors - metabolism | Ribonucleoproteins, Small Nuclear - chemistry | Protein Stability | Ribonucleoprotein, U5 Small Nuclear - chemistry | Saccharomyces cerevisiae Proteins - ultrastructure | Catalytic Domain | Biocatalysis | Introns - genetics | RNA Splice Sites - genetics | Models, Molecular | Nuclear Proteins - metabolism | RNA Precursors - genetics | Spliceosomes - ultrastructure | Nuclear Proteins - chemistry | Saccharomyces cerevisiae - chemistry | Cryoelectron Microscopy | RNA Precursors - ultrastructure | Models, Biological | Saccharomyces cerevisiae Proteins - metabolism | Protein Binding | Ribonucleoprotein, U4-U6 Small Nuclear - chemistry | RNA, Small Nuclear - chemistry | RNA, Small Nuclear - metabolism | Ribonucleoproteins, Small Nuclear - metabolism | Saccharomyces cerevisiae Proteins - chemistry | Yeast | Ribonucleoproteins (small nuclear) | Molecular structure | mRNA | Saccharomyces | Ribonucleoproteins (U2 small nuclear) | Electron microscopy | Ribonucleic acid--RNA | snRNA | Proteins | DNA helicase | Transmission electron microscopy | Ribonucleic acids | Catalysis | Atomic structure | Saccharomyces cerevisiae
Journal Article
Human Molecular Genetics, ISSN 0964-6906, 06/2011, Volume 20, Issue 11, pp. 2116 - 2130
Journal Article
The Journal of Organic Chemistry, ISSN 0022-3263, 05/2018, Volume 83, Issue 9, pp. 5187 - 5198
Thailanstatin A has been isolated recently from the fermentation broth of B. thailandensis MSMB43. We describe here an enantioselective convergent synthesis of... 
U4/U6.U5 TRI-SNRNP | PLADIENOLIDE B | FR901464 | ANALOGS | SPLICEOSOME | TRANSCRIPTION | CHEMISTRY, ORGANIC | BURKHOLDERIA SP | SUBSTANCES | DERIVATIVES | PRE-MESSENGER-RNA | Pyrans - chemical synthesis | RNA Splicing - drug effects | Chemistry Techniques, Synthetic | Esters - chemistry | Pyrans - chemistry | Stereoisomerism | Pyrans - pharmacology
Journal Article
Journal Article