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American Journal of Physiology - Endocrinology and Metabolism, ISSN 0193-1849, 2015, Volume 309, Issue 8, pp. E736 - E746
Journal Article
Journal Article
Journal of Eukaryotic Microbiology, ISSN 1066-5234, 09/2016, Volume 63, Issue 5, pp. 657 - 678
Comparison of the genomes of free‐living Bodo saltans and those of parasitic trypanosomatids reveals that the transition from a free‐living to a parasitic life... 
Trypanosoma | Leishmania | parasitism | adaptation | Leptomonas | Phytomonas | lateral gene transfer | Lateral gene transfer | Parasitism | Adaptation | LIFE-CYCLE | DEPENDENT PHOSPHOFRUCTOKINASE | FATTY-ACID SYNTHESIS | DIFFERENTIAL EXPRESSION | DIHYDROOROTATE DEHYDROGENASE | INSECT TRYPANOSOMATIDS | MICROBIOLOGY | BLOOD-STREAM FORM | SOLANESYL-DIPHOSPHATE SYNTHASE | COMPLEX-I | UBIQUINONE BIOSYNTHESIS | Mitochondria - enzymology | Dolichol - metabolism | Reactive Oxygen Species | Genes, Protozoan - genetics | Trypanosomatina - genetics | Microbodies - metabolism | Ubiquinone - metabolism | Vitamins - metabolism | Pyrimidines - biosynthesis | Eukaryota - metabolism | Protozoan Proteins - genetics | Protein Prenylation | Pyrimidines - metabolism | Amino Acids - metabolism | Coenzymes - metabolism | Trypanosomatina - metabolism | Urea - metabolism | Phospholipids - metabolism | Kinetoplastida - metabolism | Gluconeogenesis | Bacteria - metabolism | Oxidoreductases - metabolism | Purines - metabolism | Carbohydrate Metabolism | Ergosterol - biosynthesis | Lipid Metabolism | Mitochondria - metabolism | Kinetoplastida - enzymology | Mevalonic Acid - metabolism | Bacteria - genetics | Peroxisomes - metabolism | Polyamines - metabolism | Trypanosomatina - enzymology | Eukaryota - genetics | Kinetoplastida - genetics | Folic Acid - metabolism | Glycolysis | Purines - biosynthesis | Pentose Phosphate Pathway | Oxidases | Thiols | Isoenzymes | Genes | Genomics | Tryptophan | Carbohydrate metabolism | Phylogeny | Fatty acids | Fructose | Glucose metabolism | Pyrimidines | Anopheles | Lysine | Physiological aspects | Comparative analysis | Phosphotransferases
Journal Article
PLoS ONE, ISSN 1932-6203, 10/2014, Volume 9, Issue 11, p. e112945
The kynurenine pathway (KP) is the principal route of L-tryptophan (TRP) catabolism leading to the production of kynurenine (KYN), the neuroprotectants,... 
QUINOLINIC ACID | INHIBITION | METABOLISM | AMINOTRANSFERASE | MULTIDISCIPLINARY SCIENCES | INDOLEAMINE 2,3-DIOXYGENASE | T-CELL | TUMORAL IMMUNE RESISTANCE | TRYPTOPHAN DEGRADATION | IDO EXPRESSION | BRAIN | Immunohistochemistry | Indoleamine-Pyrrole 2,3,-Dioxygenase - genetics | Indoleamine-Pyrrole 2,3,-Dioxygenase - metabolism | Kynurenic Acid - blood | Gene Expression - drug effects | Humans | Kynurenine - biosynthesis | Brain Neoplasms - physiopathology | Picolinic Acids - blood | Quinolinic Acid - blood | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Kynurenic Acid - metabolism | Carboxy-Lyases - genetics | Tryptophan - metabolism | Brain Neoplasms - metabolism | Picolinic Acids - metabolism | Antigens, CD - metabolism | Glioma - metabolism | Glioma - genetics | Kynurenine - blood | Tryptophan - blood | Carboxy-Lyases - metabolism | Tumor Cells, Cultured | Astrocytes - drug effects | Disaccharides | Cells, Cultured | Brain Neoplasms - genetics | Biosynthetic Pathways | Reverse Transcriptase Polymerase Chain Reaction | Glucuronates | Tryptophan Oxygenase - metabolism | Tryptophan Oxygenase - genetics | Antigens, Differentiation, Myelomonocytic - metabolism | Quinolinic Acid - metabolism | CD11b Antigen - metabolism | Glioma - physiopathology | Interferon-gamma - pharmacology | Astrocytes - metabolism | Tryptophan | Niacinamide | Methyl aspartate | Enzymes | Metabolites | Gliomas | NADPH | Neuroprotection | Brain | Brain tumors | Brain cancer | Glioblastoma | Tryptophan 2,3-dioxygenase | Immunity | DNA repair | Picolinic acid | Rodents | Glioma cells | L-Tryptophan | Kynurenic acid | Quinolinic acid | Deoxyribonucleic acid--DNA | Pyridines | Medical research | Hydroxylase | Adenine | Kynurenine-oxoglutarate transaminase | NAD | Acids | γ-Interferon | Nicotinamide adenine dinucleotide | Catabolism | Nicotinamide | Interferon | Tumors | Deoxyribonucleic acid | DNA
Journal Article
Nature, ISSN 0028-0836, 05/2018, Volume 557, Issue 7707, pp. 724 - 728
Microglia and astrocytes modulate inflammation and neurodegeneration in the central nervous system (CNS)(1-3). Microglia modulate pro-inflammatory and... 
ACTIVATION | ARYL-HYDROCARBON RECEPTOR | MULTIDISCIPLINARY SCIENCES | TGF-ALPHA | CENTRAL-NERVOUS-SYSTEM | SPINAL-CORD-INJURY | DIVERSITY | VEGF-B | EXPRESSION | CNS INFLAMMATION | ENDOTHELIAL GROWTH-FACTOR | Inflammation - pathology | Microglia - metabolism | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Astrocytes - pathology | Central Nervous System - pathology | Vascular Endothelial Growth Factor B - biosynthesis | Tryptophan - metabolism | Lipopolysaccharide Receptors - metabolism | Inflammation - metabolism | Tryptophan - deficiency | Microglia - pathology | Receptors, Aryl Hydrocarbon - metabolism | Female | Transforming Growth Factor alpha - metabolism | Central Nervous System - microbiology | Disease Models, Animal | Encephalomyelitis, Autoimmune, Experimental - microbiology | Multiple Sclerosis - metabolism | Transforming Growth Factor alpha - biosynthesis | Symbiosis | Inflammation - microbiology | Encephalomyelitis, Autoimmune, Experimental - pathology | ErbB Receptors - metabolism | Mice, Inbred C57BL | Cells, Cultured | Vascular Endothelial Growth Factor Receptor-1 - metabolism | Animals | Vascular Endothelial Growth Factor B - metabolism | Encephalomyelitis, Autoimmune, Experimental - prevention & control | Multiple Sclerosis - pathology | Inflammation - prevention & control | Mice | Astrocytes - metabolism | Physiological aspects | Microbiological research | Metabolites | Transforming growth factors | Astrocytes | Vascular endothelial growth factor | Regulators | Multiple sclerosis | Encephalomyelitis | Transcription | Central nervous system | Hydrocarbons | Nervous system | CD14 antigen | Recruitment | Angiogenesis | Signal transduction | Neurotoxicity | Microorganisms | Neurodegeneration | Aromatic compounds | Bone marrow | ErbB-1 protein | Tryptophan | Inflammation | Gene expression | Experimental allergic encephalomyelitis | Microglia | Neurological diseases | Diet | Lymphocytes B | Flora | Spinal cord injuries | Alzheimers disease | Life Sciences | Immunology
Journal Article
Science, ISSN 0036-8075, 1/2009, Volume 323, Issue 5910, pp. 101 - 106
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2017, Volume 23, Issue 6, pp. 733 - 741
Blood vessels in the central nervous system (CNS) are controlled by neuronal activity. For example, widespread vessel constriction (vessel tone) is induced by... 
MEDICINE, RESEARCH & EXPERIMENTAL | PIAL VESSELS | RAT | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRACE AMINES | SYNAPTIC-TRANSMISSION | HYPOXIA | CELL BIOLOGY | CENTRAL-NERVOUS-SYSTEM | LOCOMOTOR FUNCTION | CEREBRAL-ARTERIES | RECEPTORS | BRAIN | Capillaries - pathology | Serotonin 5-HT1 Receptor Antagonists - pharmacology | Receptors, Adrenergic, alpha-2 - metabolism | Transcriptome | Capillaries - drug effects | RNA, Messenger - metabolism | Oxygen - metabolism | Hypoxia - metabolism | Receptors, Serotonin, 5-HT1 - metabolism | Spinal Cord Injuries - pathology | Receptor, Serotonin, 5-HT1B - metabolism | Aromatic-L-Amino-Acid Decarboxylases - metabolism | Tyramine - metabolism | Capillaries - metabolism | Locomotion - drug effects | Injections, Spinal | Capillaries - physiopathology | Spinal Cord Injuries - metabolism | Pericytes - metabolism | Vasoconstriction | Rats | Microscopy, Interference | Oxygen Inhalation Therapy | Microscopy, Confocal | Animals | Norepinephrine - metabolism | Tryptamines - metabolism | Serotonin - metabolism | Spinal Cord Injuries - physiopathology | Biogenic Monoamines - metabolism | Locomotion - physiology | Enzymes | Care and treatment | Analysis | Tryptophan | Spinal cord injuries | Dosage and administration | Drug therapy | Health aspects | Noradrenaline | Blood flow | spinal cord injury | AADC | hypoxia | pericyte | capillary | locomotion | Trace amines | neurovascular coupling | 5-HT1B receptor | motoneurons | ischemia
Journal Article
Psychoneuroendocrinology, ISSN 0306-4530, 08/2018, Volume 94, pp. 1 - 10
Journal Article
Nature Medicine, ISSN 1078-8956, 06/2016, Volume 22, Issue 6, pp. 586 - 597
Astrocytes have important roles in the central nervous system (CNS) during health and disease. Through genome-wide analyses we detected a transcriptional... 
MEDICINE, RESEARCH & EXPERIMENTAL | EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS | BIOCHEMISTRY & MOLECULAR BIOLOGY | MYELOID CELLS | BLOOD-BRAIN-BARRIER | BETA | CELL BIOLOGY | RESPONSES | MULTIPLE-SCLEROSIS | REGULATORY T-CELLS | DIFFERENTIATION | NF-KAPPA-B | EXPRESSION | Optical Imaging | Cell Proliferation | Central Nervous System - metabolism | Encephalomyelitis, Autoimmune, Experimental - metabolism | Humans | Encephalomyelitis, Autoimmune, Experimental - immunology | Immunoblotting | Gene Expression Profiling | Chromatography, High Pressure Liquid | Glial Fibrillary Acidic Protein - metabolism | Interferon Type I - immunology | Suppressor of Cytokine Signaling Proteins | Tryptophan - metabolism | Case-Control Studies | Central Nervous System - immunology | Tryptophanase - metabolism | Gene Knockdown Techniques | Indoles - metabolism | STAT1 Transcription Factor - metabolism | Lactobacillus reuteri | Astrocytes - immunology | Chromatin Immunoprecipitation | Polymerase Chain Reaction | Receptors, Aryl Hydrocarbon - metabolism | Chemokine CCL2 - metabolism | Receptor, Interferon alpha-beta - genetics | Multiple Sclerosis - metabolism | Indican - urine | Serotonin | Gastrointestinal Microbiome | Inflammation | Mice, Knockout | Animals | Interferon-beta - pharmacology | Fluorescent Antibody Technique | Multiple Sclerosis - immunology | T-Lymphocytes - immunology | Mice | Myxovirus Resistance Proteins - metabolism | Receptors, Aryl Hydrocarbon - immunology | Nitric Oxide Synthase Type II - metabolism | Microbiota (Symbiotic organisms) | Astrocytes | Physiological aspects | Tryptophan | Interferon | Genetic aspects | Research | Autoimmunity | Multiple sclerosis | Care and treatment | Encephalomyelitis | Central nervous system | Prevention | Metabolites | Analysis | Dosage and administration | Diagnosis | Health aspects | Nervous system | Microorganisms | Immune system
Journal Article