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Chemical Communications, ISSN 1359-7345, 06/2015, Volume 51, Issue 48, pp. 9868 - 9871
A small library of 3-[(4-hydroxycarbamoylphenyl)aminomethyl]-benzothiophenes was prepared and assessed as a novel class of HDAC6 inhibitors, leading to the... 
ISOFORM | HISTONE DEACETYLASE INHIBITORS | TUBASTATIN | CHEMISTRY, MULTIDISCIPLINARY | MUTAGENICITY | Activated | Libraries | Inhibitors | Synthesis | Inhibition
Journal Article
Pharmacological Research, ISSN 1043-6618, 01/2016, Volume 103, pp. 328 - 339
Histone deacetylases (HDACs) are key epigenetic enzymes and emerging drug targets in cancer and neurodegeneration. Pan-HDAC inhibitors provided neuroprotection... 
Zebrafish | Mitochondria | MS-275 | HDAC inhibitors | Tubastatin A | Parkinson’s disease
Journal Article
Aging, ISSN 1945-4589, 03/2019, Volume 11, Issue 6, pp. 1759 - 1777
Tubastatin A (TubA) is a highly selective histone deacetylase 6 (HDAC6) inhibitor. As expected, mouse germinal vesicle oocytes fail to extrude the first polar... 
Germinal vesicle oocyte | Meiotic oocyte maturation | RNA-seq | Tubastatin A | HDAC6 | Sirtuin family
Journal Article
Chemical Communications, ISSN 1359-7345, 2016, Volume 52, Issue 15, pp. 3219 - 3222
A mini library of HDAC inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach. Four compounds were identified as... 
CELLS | DEACETYLASE 6 INHIBITORS | ACID | HISTONE DEACETYLASES | ENZYMES | DOCKING | TUBASTATIN | CANCER | CHEMISTRY, MULTIDISCIPLINARY | Libraries | Selectivity | Inhibitors | Mini | Synthesis
Journal Article
by Wang, JJ and Zhao, LL and Wei, ZK and Zhang, X and Wang, YA and Li, F and Fu, YH and Liu, B
INTERNATIONAL IMMUNOPHARMACOLOGY, ISSN 1567-5769, 03/2018, Volume 56, pp. 230 - 234
Histone deacetylase 6 (HDAC6) is the sole member of the HDAC family, that is predominantly located in the cytoplasm and has substrate specificity for... 
IMMUNITY | ACTIVATION | Tubastatin | Cytokines | Inflammation | IMMUNOLOGY | HDAC6 | NF-kappa B | ROS | MASTITIS | PHARMACOLOGY & PHARMACY | TUBULIN | EXPRESSION | GLAND
Journal Article
Pharmacological Research, ISSN 1043-6618, 01/2016, Volume 103, pp. 328 - 339
Journal Article
Pathogens and disease, ISSN 2049-632X, 08/2018, Volume 76, Issue 6
Interleukin (IL)-10 plays a key role in immune response following mycobacterial infection, which can be inhibited by histone deacetylase (HDAC) 6. In this... 
INFECTIOUS DISEASES | PROTECTION | HOST | MICROBIOLOGY | INTERLEUKIN-10 | IMMUNOLOGY | TUBASTATIN | IL-10 | HDAC6 | RESPONSES | immune response | inflammation | pulmonary mycobacterial infection | TH1 | TRANSCRIPTIONAL REGULATION | EXPRESSION
Journal Article
Chemical communications (Cambridge, England), ISSN 1359-7345, 02/2016, Volume 52, Issue 15, pp. 3219 - 3222
A mini library of HDAC inhibitors with peptoid-based cap groups was synthesized using an efficient multicomponent approach. Four compounds were identified as... 
Histone Deacetylase Inhibitors - pharmacology | Histone Deacetylase Inhibitors - chemical synthesis | Molecular Docking Simulation | Histone Deacetylase Inhibitors - chemistry | Peptoids - chemistry | Drug Design
Journal Article
International Journal of Cancer, ISSN 0020-7136, 08/2019, Volume 145, Issue 3, pp. 735 - 747
Our study investigates the biochemical and functional impact of selective histone deacetylase 6 (HDAC6) inhibitors, a promising class of novel therapeutics, in... 
inhibition | Tubathian A | histone deacetylase 6 | Tubastatin A | tumour | Analysis | Vorinostat | Therapeutics | Tubulins | Cancer | Homeopathy | Materia medica and therapeutics | Histone deacetylase | CRISPR | Invasiveness | Pharmacology | Selectivity | Tumor cell lines | Inhibitors | Tubulin | Cell lines | Histones | Acetylation | Inhibition | Tumors | Index Medicus
Journal Article
Journal of Cellular Biochemistry, ISSN 0730-2312, 12/2019, Volume 120, Issue 12, pp. 19590 - 19609
Histone deacetylases (HDAC) inhibitors can protect nerve cells after a stroke, but it is unclear which HDAC isoform is involved in this effect. We studied... 
cortex | Tubastatin A | class II histone deacetylases | brain regeneration | photothrombotic infarction | stroke | HDAC6 | Translocation | Histone deacetylase | Neuroprotection | Brain | Stroke | Neurons | Cortex | Cortex (somatosensory) | Recovery | Nuclear transport | Tubulin | Ischemia | Histones | Acetylation | Localization | Apoptosis
Journal Article
Pharmacological Research, ISSN 1043-6618, 08/2019, Volume 146, p. 104281
Cystathionine γ-lyase (CSEγ) is a hydrogen sulfide (H S)-producing enzyme. Endothelial H S production can mediate vasodilatory effects, contributing to the... 
Hydrogen sulfide | Hypertension | Cystathionine γ-lyase | Angiotensin II | Tubastatin A | Histone deacetylase 6 | ACETYLATION | H2S | PHOSPHATIDYLINOSITOL 4-PHOSPHATE 5-KINASE | HYDROGEN-SULFIDE | HDAC6 | UBIQUITINATION | RESPONSES | ENDOTHELIUM | PHARMACOLOGY & PHARMACY | MICE | Cystathionine gamma-lyase | CONTRIBUTES
Journal Article
Journal of Biomolecular Structure and Dynamics, ISSN 0739-1102, 12/2019, Volume 37, Issue 18, pp. 4701 - 4720
HDAC6 is a protein involved in cancer, neurodegenerative disease and inflammatory disorders. To date, the full three-dimensional (3D) structure of human HDAC6... 
HDAC6 inhibitors | DD1 | CAY10603 | DD2 | Histone deacetylases 6 | MM/GBSA | Tubastatin | Nexturastat | Rocilinostat | HPOB | molecular dynamic simulation | Tubacin | DESIGN | DOCKING | BIOCHEMISTRY & MOLECULAR BIOLOGY | GBSA | MOLECULAR-MECHANICS | BIOPHYSICS | DYNAMICS | FORCE-FIELD | SIMULATIONS | TUBULIN | PROTEINS | HISTONE DEACETYLASE
Journal Article