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Cancer Discovery, ISSN 2159-8274, 12/2013, Volume 3, Issue 12, pp. 1355 - 1363
The success in lung cancer therapy with programmed death (PD)-1 blockade suggests that immune escape mechanisms contribute to lung tumor pathogenesis. We... 
CELLS | MICROENVIRONMENT | ONCOLOGY | ADENOCARCINOMA | GROWTH | SENSITIVITY | ANTIBODY | REGULATORY T | MUTATIONS | BLOCKADE | EXPRESSION
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 08/2018, Volume 71, Issue 4, pp. 581 - 591.e5
Biological signals need to be robust and filter small fluctuations yet maintain sensitivity to signals across a wide range of magnitudes. Here, we studied how... 
systems biology | cell-cycle arrest | signaling dynamics | DNA damage | live-cell imaging | single cells | heterogeneity | p53 | SENESCENCE PROGRAM | CANCER-TREATMENT | BIOCHEMISTRY & MOLECULAR BIOLOGY | DNA-DAMAGE | PROLIFERATION-QUIESCENCE DECISION | DYNAMICS | S-PHASE | HUMAN FIBROBLASTS | SUPPRESSION | EXPRESSION | P21 | CELL BIOLOGY | Gamma Rays | RNA, Small Interfering - genetics | Retinal Pigment Epithelium - metabolism | Epithelial Cells - metabolism | Tumor Suppressor Protein p53 - antagonists & inhibitors | Humans | Green Fluorescent Proteins - genetics | Time-Lapse Imaging | Tumor Suppressor Protein p53 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - genetics | Cyclin-Dependent Kinase Inhibitor p21 - metabolism | Cell Cycle Checkpoints - genetics | Retinal Pigment Epithelium - radiation effects | Protein Stability | Epithelial Cells - cytology | Genes, Reporter | Cyclin-Dependent Kinase 2 - metabolism | Green Fluorescent Proteins - metabolism | Epithelial Cells - radiation effects | Signal Transduction | Gene Expression Regulation | Tumor Suppressor Protein p53 - metabolism | Cell Division - radiation effects | Cyclin-Dependent Kinase 2 - genetics | Models, Statistical | Cell Cycle Checkpoints - radiation effects | Luminescent Proteins - genetics | DNA Damage | Cell Line, Transformed | Retinal Pigment Epithelium - cytology | Cell Proliferation - radiation effects | Luminescent Proteins - metabolism | RNA, Small Interfering - metabolism | Tumor proteins | Medical colleges | Cells | Systems biology | cell cycle arrest
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 06/2015, Volume 10, Issue 6, pp. 910 - 923
Epidermal growth factor receptor (EGFR) mutation status was reported to be associated with programmed death-ligand 1 (PD-L1) expression. However, the molecular... 
PD-L1 | NSCLC | PD-1 | EGFR | Tyrosine kinase inhibitors | LUNG | CELLS | B7-H1 EXPRESSION | DEATH-LIGAND 1 | MELANOMA | ONCOLOGY | PATHWAY | IMMUNOTHERAPY | RESPIRATORY SYSTEM | POOR-PROGNOSIS | GROWTH | INHIBITORS | Tumor Escape - drug effects | Lung Neoplasms - drug therapy | Receptor, Epidermal Growth Factor - genetics | Sequence Deletion | Up-Regulation | Exons | Humans | Programmed Cell Death 1 Receptor - antagonists & inhibitors | Molecular Targeted Therapy | Receptor, Epidermal Growth Factor - metabolism | T-Lymphocytes - pathology | Lung Neoplasms - genetics | Receptor, Epidermal Growth Factor - immunology | Lung Neoplasms - enzymology | Signal Transduction | Carcinoma, Non-Small-Cell Lung - genetics | Programmed Cell Death 1 Receptor - metabolism | B7-H1 Antigen - genetics | B7-H1 Antigen - immunology | Carcinoma, Non-Small-Cell Lung - immunology | B7-H1 Antigen - metabolism | Lung Neoplasms - immunology | Apoptosis - immunology | B7-H1 Antigen - antagonists & inhibitors | Interferon-gamma - immunology | Cell Line, Tumor | Receptor, Epidermal Growth Factor - antagonists & inhibitors | T-Lymphocytes - immunology | Protein Kinase Inhibitors - pharmacology | Carcinoma, Non-Small-Cell Lung - drug therapy | Carcinoma, Non-Small-Cell Lung - enzymology | Programmed Cell Death 1 Receptor - immunology | Programmed Cell Death 1 Receptor - genetics | Interferon-gamma - biosynthesis
Journal Article
Journal of Controlled Release, ISSN 0168-3659, 05/2015, Volume 206, pp. 37 - 48
The cancer stem cell (CSC) marker CD133 is an attractive target to improve antitumor therapy. We have used photochemical internalization (PCI) for the... 
Controlled drug delivery | Immunotoxin | Photodynamic therapy | Targeting | Cancer therapy | Cancer stem cells | Photochemical internalization | Autophagy | Endosomal escape | CD133 | APOPTOSIS | DRUG-DELIVERY | MARKER | CD133 EXPRESSION | OVARIAN-CANCER | CHEMISTRY, MULTIDISCIPLINARY | BREAST-CANCER | COLORECTAL-CANCER | PHARMACOLOGY & PHARMACY | TUMOR-GROWTH | Adenocarcinoma - pathology | Neoplastic Stem Cells - drug effects | Rectum - pathology | Humans | Colon - drug effects | Photosensitizing Agents - metabolism | Immunotoxins - pharmacology | Ribosome Inactivating Proteins, Type 1 - pharmacology | Photochemotherapy | Endosomes - metabolism | Drug Delivery Systems | Photosensitizing Agents - administration & dosage | Photosensitizing Agents - pharmacology | Adenocarcinoma - metabolism | Immunotoxins - administration & dosage | Rectum - drug effects | Neoplastic Stem Cells - metabolism | Colorectal Neoplasms - drug therapy | Light | Endosomes - drug effects | Immunotoxins - metabolism | Colorectal Neoplasms - metabolism | Colon - pathology | Rectum - metabolism | Adenocarcinoma - drug therapy | Colon - metabolism | Ribosome Inactivating Proteins, Type 1 - metabolism | Cell Line, Tumor | Colorectal Neoplasms - pathology | Ribosome Inactivating Proteins, Type 1 - administration & dosage | Melanoma | Stem cells | Colorectal cancer | Cancer | Index Medicus
Journal Article
Journal Article
Immunology, ISSN 0019-2805, 05/2007, Volume 121, Issue 1, pp. 1 - 14
Journal Article