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Science Translational Medicine, ISSN 1946-6234, 03/2012, Volume 4, Issue 127, pp. 127ps10 - 127ps10
Most advanced solid tumors remain incurable, with resistance to chemotherapeutics and targeted therapies a common cause of poor clinical outcome. Intratumor... 
MEDICINE, RESEARCH & EXPERIMENTAL | LUNG-CANCER | GEFITINIB | CLONAL SELECTION | EVOLUTION | METASTASIS | MET AMPLIFICATION | SIGNATURES | MUTATION | RESISTANCE | REVEALS | CELL BIOLOGY | Drug Resistance, Neoplasm - genetics | Neoplasms - genetics | Genomics | Humans | Biomarkers, Tumor - metabolism | Models, Genetic | Mutation - genetics | Neoplasms - pathology | Genetic Heterogeneity
Journal Article
Nature, ISSN 0028-0836, 09/2015, Volume 525, Issue 7567, pp. 119 - 123
Journal Article
Journal of Thoracic Oncology, ISSN 1556-0864, 10/2018, Volume 13, Issue 10, pp. 1496 - 1507
Data regarding the pre-treatment intertumor heterogeneity of potential biomarkers in advanced-stage lung cancers is limited. A finding of such heterogeneity... 
RNA sequencing | Biomarkers | Tumor heterogeneity | RET fusion | Autopsy | Immune-related markers | RET | READ ALIGNMENT | ADENOCARCINOMAS | ACQUIRED-RESISTANCE | EGFR MUTATIONS | OPEN-LABEL | KINASE INHIBITOR | GENOME | AMPLIFICATION | ONCOLOGY | RESPIRATORY SYSTEM | FUSIONS | Lung Neoplasms - genetics | Humans | Aged, 80 and over | Female | Male | Aged | Genetic Heterogeneity | Evolution, Molecular
Journal Article
Cancer Letters, ISSN 0304-3835, 2014, Volume 357, Issue 1, pp. 63 - 68
Journal Article
Nature Communications, ISSN 2041-1723, 10/2016, Volume 7, Issue 1, pp. 13200 - 13200
Multiple synchronous lung cancers (MSLCs) present a clinical dilemma as to whether individual tumours represent intrapulmonary metastases or independent... 
MUTAGENESIS | INSTABILITY | MULTIDISCIPLINARY SCIENCES | METASTASES | CELL CARCINOMAS | FRAMEWORK | PATTERNS | CLASSIFICATION | TUMORS | SOMATIC MUTATIONS | DISCOVERY | Index Medicus
Journal Article
Journal Article
Current Opinion in Genetics & Development, ISSN 0959-437X, 02/2018, Volume 48, pp. 89 - 96
There is enormous diversity in the genetic makeup and gene expression profiles between and within tumors. This heterogeneity leads to phenotypic variation and... 
THERAPEUTIC SUPPRESSION | MESSENGER-RNA | 4E-BINDING PROTEIN-1 | GENETICS & HEREDITY | INTRA-TUMOR HETEROGENEITY | CLONAL EVOLUTION | INDUCE APOPTOSIS | PROTEIN-PHOSPHORYLATION | 3 ABUNDANCE CLASSES | IMATINIB MESYLATE | CANCER CELL-LINES | CELL BIOLOGY | Gene expression
Journal Article