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Nature Biotechnology, ISSN 1087-0156, 2014, Volume 32, Issue 6, pp. 569 - 576
  Monomeric CRISPR-Cas9 nucleases are widely used for targeted genome editing but can induce unwanted off-target mutations with high frequencies. Here we... 
Genetic research | Nucleases | Genetic aspects | Genetic engineering | Zinc finger proteins | Research | Biotechnology | Enzymes | Mutation | Genomics
Journal Article
Nature, ISSN 0028-0836, 07/2017, Volume 547, Issue 7664, pp. 413 - 418
Immunotherapy with PD-1 checkpoint blockade is effective in only a minority of patients with cancer, suggesting that additional treatment strategies are... 
MELANOMA | T-CELL IMMUNITY | GENE | MULTIDISCIPLINARY SCIENCES | ACUTE LYMPHOBLASTIC-LEUKEMIA | CD94/NKG2A | BLOCKADE | EXPRESSION | PD-1 | HLA-E | Tumor Escape - drug effects | Immunotherapy - methods | Loss of Function Mutation | Tumor Escape - genetics | Genomics | Humans | NF-kappa B - metabolism | Interferons - immunology | Melanoma, Experimental - immunology | T-Lymphocytes - drug effects | Tumor Escape - immunology | Melanoma, Experimental - therapy | Melanoma, Experimental - pathology | Antigen Presentation - genetics | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - deficiency | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - genetics | Antigen Presentation - immunology | Unfolded Protein Response | CRISPR-Cas Systems - genetics | Gene Editing | Xenograft Model Antitumor Assays | Protein Tyrosine Phosphatase, Non-Receptor Type 2 - metabolism | Animals | Melanoma, Experimental - genetics | T-Lymphocytes - immunology | Mice | Care and treatment | Analysis | Immunotherapy | Diagnosis | Genetic screening | Methods | Cancer | Animal models | PD-1 protein | Genes | Genomes | Synergism | Proteins | Signal transduction | Clonal deletion | Lymphocytes | Protein folding | Tyrosine | Antigen presentation | NF-κB protein | CRISPR | Melanoma | Medical screening | Patients | Screening | Signaling | Immune checkpoint | PD-L1 protein | Interferon | Genetic testing | Tumors | Protein-tyrosine-phosphatase | PTPN2 protein
Journal Article
Nature Reviews Molecular Cell Biology, ISSN 1471-0072, 09/2016, Volume 17, Issue 9, pp. 597 - 604
Journal Article
Journal of Molecular Biology, ISSN 0022-2836, 01/2019, Volume 431, Issue 1, pp. 66 - 87
Prokaryotic adaptive immune systems use Clustered Regularly Interspaced Short Palindromic Repeats (CRISPRs) and CRISPR-associated (Cas) proteins for RNA-guided... 
Type VI CRISPR–Cas systems | C2c2 | programmable RNA targeting | Cas13 | CRISPR–Cas immunity | DEFENSE | CRISPR-Cas immunity | PROTEIN | CRYSTAL-STRUCTURE | BIOCHEMISTRY & MOLECULAR BIOLOGY | Type VI CRISPR-Cas systems | NUCLEIC-ACID DETECTION | CLEAVAGE | ADAPTIVE IMMUNITY | EVOLUTION | DNA | BINDING | REVEALS
Journal Article
Journal Article
Molecular Cell, ISSN 1097-2765, 04/2019, Volume 74, Issue 1, pp. 132 - 142.e5
Bacteria and archaea have evolved sophisticated adaptive immune systems that rely on CRISPR RNA (crRNA)-guided detection and nuclease-mediated elimination of... 
CRISPR | anti-CRISPR | Acr | Cas | type I-F | Csy | cryo-EM | Cascade | crRNA | BINDING MODES | FOREIGN DNA | INHIBITION | BIOCHEMISTRY & MOLECULAR BIOLOGY | CONFORMATIONAL CONTROL | CASCADE | INTERFERENCE | SURVEILLANCE COMPLEX | CAS SYSTEM | R-LOOP FORMATION | SPACER ACQUISITION | CELL BIOLOGY | RNA | Analysis
Journal Article
Cell, ISSN 0092-8674, 10/2019, Volume 179, Issue 2, pp. 448 - 458.e11
Bacteria and archaea possess a striking diversity of CRISPR-Cas systems divided into six types, posing a significant barrier to viral infection. As part of the... 
collateral RNA degradation | anti-CRISPR | cell dormancy | AcrIIIB | middle/late viral genes | CRISPR-Cas type III accessory RNase | Cmr2 (Cas10) | Cmr | DEFENSE | READ ALIGNMENT | RNA CLEAVAGE | DNA CLEAVAGE | BACTERIOPHAGE | REPLICATION | SULFOLOBALES | MECHANISM | GENOMES | BIOCHEMISTRY & MOLECULAR BIOLOGY | RESISTANCE | CELL BIOLOGY | Virus diseases | Ribonuclease | RNA | Health aspects
Journal Article
Nature, ISSN 0028-0836, 09/2017, Volume 549, Issue 7670, pp. 111 - 115
The majority of genetic variants associated with common human diseases map to enhancers, non-coding elements that shape cell-type-specific transcriptional... 
INTERLEUKIN-2 | ANTIBODIES | AUTOIMMUNE | GENE | MULTIDISCIPLINARY SCIENCES | LOCI | EXPRESSION | Antigens, CD - immunology | Antigens, CD - biosynthesis | Humans | Interleukin-2 Receptor alpha Subunit - biosynthesis | Lectins, C-Type - immunology | Autoimmunity - genetics | Lectins, C-Type - biosynthesis | Lectins, C-Type - genetics | Antigens, CD - genetics | Interleukin-2 Receptor alpha Subunit - genetics | Female | Receptors, Antigen, T-Cell - immunology | Th17 Cells - cytology | Cell Differentiation | Clustered Regularly Interspaced Short Palindromic Repeats - genetics | Interleukin-2 Receptor alpha Subunit - immunology | Cell Line | Antigens, Differentiation, T-Lymphocyte - immunology | Gene Expression Regulation - genetics | CRISPR-Cas Systems - genetics | Animals | Antigens, Differentiation, T-Lymphocyte - genetics | Th17 Cells - immunology | Enhancer Elements, Genetic - genetics | Mice | Receptors, Antigen, T-Cell - genetics | Antigens, Differentiation, T-Lymphocyte - biosynthesis | Chromatin - genetics | Genetic research | Genetic aspects | Research | RNA processing | Immunity | Interleukin 2 receptors | CRISPR | Chromatin | Animal models | Disease | Transcription | Helper cells | Lymphocytes T | Inflammation | T cell receptors | Genetic diversity | Gene deletion | Gene expression | Gene sequencing | Studies | CD69 antigen | Immunology | Clonal deletion | Perturbation methods | Lymphocytes | Genetic engineering | Gene mapping | Immune system
Journal Article
细胞研究:英文版, ISSN 1001-0602, 2016, Volume 26, Issue 12, pp. 1273 - 1287
Clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated (Cas) systems in bac- teria and archaea provide adaptive immunity against... 
LasR | Pseudomonas aeruginosa | Quorum sensing | Type I CRISPR | Endogenous targeting | DEFENSE | COMPLEX | quorum sensing |