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Free Radical Biology and Medicine, ISSN 0891-5849, 07/2017, Volume 108, pp. S100 - S100
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 12/2018, Volume 115, Issue 49, p. 12483
The proinflammatory cytokine IL-1[beta] plays critical roles in inflammatory and autoimmune diseases. IL-1[beta] signaling is tightly regulated to avoid... 
Interleukins | Ubiquitin-proteasome system | Health aspects
Journal Article
American Journal of Respiratory and Critical Care Medicine, ISSN 1073-449X, 10/2016, Volume 194, Issue 7, pp. 821 - 830
Critical illness survivors often experience permanent functional disability due to intensive care unit (ICU)-acquired weakness. The mechanisms responsible for... 
Mitochondria | Muscle atrophy | Satellite cell | Ubiquitin-proteasome system | Autophagy
Journal Article
Proceedings of the National Academy of Sciences of the United States, ISSN 0027-8424, 12/2017, Volume 114, Issue 50, p. 13176
[alpha]-Synuclein accumulation is a pathological hallmark of Parkinson's disease (PD). Ubiquitinated [alpha]-synuclein is targeted to proteasomal or lysosomal... 
Proteins | Ubiquitin-proteasome system | Properties | Methods
Journal Article
Free Radical Biology and Medicine, ISSN 0891-5849, 07/2017, Volume 108, pp. S95 - S95
Journal Article
NATURE REVIEWS CANCER, ISSN 1474-175X, 12/2008, Volume 8, Issue 12, pp. 967 - 975
During the past century it has been established that regions within solid tumours experience mild to severe O-2 deprivation owing to aberrant vascular... 
CELL LUNG-CANCER | GLUCOSE-REGULATED PROTEINS | TRANSCRIPTIONAL ACTIVITY | HUMAN ERYTHROPOIETIN GENE | TUMOR-SUPPRESSOR FUNCTION | SOLID TUMORS | ONCOLOGY | INDUCIBLE FACTOR 1-ALPHA | FACTOR-I | NECK-CANCER | UBIQUITIN-PROTEASOME PATHWAY
Journal Article
Biology of Reproduction, ISSN 0006-3363, 2012, Volume 87, Issue 2
ABSTRACT The ubiquitin proteasome system (UPS) consists of a cascade of enzymatic reactions leading to the ubiquitination of proteins, with consequent... 
ubiquitin proteasome system | spermatogonia | differentiation | testis | gonocyte | Testis | Differentiation | Spermatogonia | Ubiquitin proteasome system | Gonocyte
Journal Article
Phytomedicine, ISSN 0944-7113, 08/2019, Volume 61, p. 152842
Parkinson's disease (PD) is an age-dependent progressive movement disorder characterized by a profound and selective loss of nigrostriatal dopaminergic... 
Protein kinase A | synuclein | Parkinson's disease | Harmine | Ubiquitin-proteasome system
Journal Article
Journal of Cell Biology, ISSN 0021-9525, 2014, Volume 204, Issue 6, pp. 869 - 879
Even with the assistance of many cellular factors, a significant fraction of newly synthesized proteins ends up mis-folded. Cells evolved protein quality... 
MISFOLDED GLYCOPROTEINS | RETICULUM-ASSOCIATED DEGRADATION | RETRO-TRANSLOCATION | HMG-COA REDUCTASE | AAA-ATPASE | MEMBRANE-PROTEIN | ENDOPLASMIC-RETICULUM | TO-CYTOSOL DISLOCATION | CLASS-I MOLECULES | UBIQUITIN-PROTEASOME PATHWAY | CELL BIOLOGY | Proteins | Control systems | Proteolysis | Quality control | Quality management | Reviews
Journal Article
Journal of Clinical Investigation, ISSN 0021-9738, 10/2017, Volume 127, Issue 10, p. 3609
During an immune response, [CD8.sup.+] T lymphocytes can undergo asymmetric division, giving rise to daughter cells that exhibit distinct tendencies to adopt... 
Metabolism | Observations | Ubiquitin-proteasome system | T cells | Health aspects
Journal Article
Cell, ISSN 0092-8674, 2011, Volume 147, Issue 4, pp. 728 - 741
Journal Article
Science, ISSN 0036-8075, 01/2015, Volume 347, Issue 6220, pp. 439 - 442
The 26S proteasome is a key player in eukaryotic protein quality control and in the regulation of numerous cellular processes. Here, we describe quantitative... 
SYSTEM | COMPLEX | UBIQUITIN | MULTIDISCIPLINARY SCIENCES | RESOLUTION | ARCHITECTURE | CLASSIFICATION | DEGRADATION | SUBTOMOGRAMS | CELL | Ubiquitin-proteasome system | Health aspects | Neural circuitry | Cellular biology | Neurons | Proteases | Proteins | Cellular | Census | Control | Quality control | Nanostructure | Position (location)
Journal Article
Nature Cell Biology, ISSN 1465-7392, 06/2016, Volume 18, Issue 6, pp. 579 - 586
Journal Article
Nature Cell Biology, ISSN 1465-7392, 07/2013, Volume 15, Issue 7, pp. 713 - 720
Journal Article