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index medicus (426) 426
animals (407) 407
depression (371) 371
neurosciences (353) 353
male (331) 331
rats (264) 264
chronic unpredictable mild stress (246) 246
depression, mental (214) 214
mice (204) 204
pharmacology & pharmacy (201) 201
disease models, animal (198) 198
antidepressants (190) 190
unpredictable mild stress (165) 165
brain (161) 161
stress (157) 157
chronic mild stress (156) 156
chronic unpredictable stress (156) 156
psychiatry (151) 151
major depression (135) 135
antidepressant (132) 132
hippocampus (128) 128
behavioral sciences (126) 126
rats, sprague-dawley (121) 121
behavior (101) 101
antidepressive agents - pharmacology (100) 100
chronic disease (95) 95
stress, psychological - metabolism (94) 94
analysis (91) 91
anxiety (90) 90
model (89) 89
depression - drug therapy (88) 88
animal-model (84) 84
hippocampus - metabolism (83) 83
rodents (81) 81
unpredictable chronic mild stress (81) 81
behavior, animal - drug effects (78) 78
mental depression (76) 76
serotonin (75) 75
corticosterone (73) 73
fluoxetine (73) 73
stress, psychological - drug therapy (73) 73
prefrontal cortex (72) 72
brain-derived neurotrophic factor (71) 71
expression (69) 69
rats, wistar (69) 69
stress, psychological - complications (68) 68
bdnf (65) 65
hippocampus - drug effects (65) 65
stress, psychological - psychology (64) 64
depression - metabolism (62) 62
neurotrophic factor (61) 61
oxidative stress (61) 61
anhedonia (59) 59
antidepressive agents - therapeutic use (58) 58
inflammation (58) 58
stress, psychological - physiopathology (58) 58
sucrose (55) 55
humans (54) 54
clinical neurology (53) 53
major depressive disorder (53) 53
research (52) 52
animal-models (50) 50
brain - metabolism (50) 50
neurogenesis (50) 50
female (49) 49
rat (49) 49
brain-derived neurotrophic factor - metabolism (48) 48
corticosterone - blood (48) 48
health aspects (48) 48
article (47) 47
biochemistry & molecular biology (46) 46
neurology (46) 46
motor activity - drug effects (44) 44
endocrinology & metabolism (43) 43
forced swimming test (41) 41
hpa axis (41) 41
physiological aspects (41) 41
pituitary-adrenal axis (41) 41
rat-brain (41) 41
swimming (41) 41
depressive disorder - drug therapy (40) 40
mild stress (39) 39
depression - etiology (38) 38
dopamine (37) 37
induced anhedonia (37) 37
unpredictable stress (37) 37
analysis of variance (35) 35
gene expression (35) 35
memory (35) 35
mood disorders (35) 35
proteins (35) 35
serotonin - metabolism (35) 35
stress, psychological - pathology (35) 35
animal models (34) 34
brain - drug effects (34) 34
depression - physiopathology (34) 34
dose-response relationship, drug (34) 34
forced swim test (34) 34
involvement (34) 34
mice, inbred c57bl (34) 34
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1. Full Text Neurobiology of chronic mild stress: Parallels to major depression
by Hill, Matthew N and Hellemans, Kim G.C and Verma, Pamela and Gorzalka, Boris B and Weinberg, Joanne
Neuroscience and Biobehavioral Reviews, ISSN 0149-7634, 10/2012, Volume 36, Issue 9, pp. 2085 - 2117
â–º Chronic mild stress produces neurobiological changes in the brain. â–º The effects of chronic mild stress parallel changes seen in major depression. â–º... 
Animal model | Depression | HPA axis | Stress | Neurobiology | CORTICOTROPIN-RELEASING HORMONE | MESSENGER-RNA EXPRESSION | ADRENERGIC-RECEPTOR BINDING | PITUITARY-ADRENOCORTICAL AXIS | CHRONIC VARIABLE STRESS | NEUROSCIENCES | ANTIDEPRESSANT-LIKE ACTIVITY | FACTOR-LIKE IMMUNOREACTIVITY | TEENAGE SUICIDE VICTIMS | CHRONIC UNPREDICTABLE STRESS | INDUCED DOPAMINE RELEASE | BEHAVIORAL SCIENCES | Brain - metabolism | Depressive Disorder, Major - physiopathology | Animals | Synaptic Transmission - physiology | Brain - physiopathology | Depressive Disorder, Major - metabolism | Stress, Psychological - metabolism | Disease Models, Animal | Stress, Psychological - physiopathology | Stress (Psychology) | Analysis | Major depressive disorder | Indexing in process
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2. Full Text Amygdala-Ventral Pallidum Pathway Decreases Dopamine Activity After Chronic Mild Stress in Rats
by Chang, Chun-hui and Grace, Anthony A
Biological Psychiatry, ISSN 0006-3223, 2014, Volume 76, Issue 3, pp. 223 - 230
Background Major depressive disorder affects more than 15% of the population across their lifespan. In this study, we used the well-characterized unpredictable... 
Psychiatry | unpredictable chronic mild stress | ventral pallidum | Amygdala | rat | ventral tegmental area | dopamine | NEURON ACTIVITY | ACTIVATION | PSYCHIATRY | BEHAVIOR | VOLUME | MODEL | NEUROSCIENCES | ANHEDONIA | HIPPOCAMPUS | CONSOLIDATION | MAJOR DEPRESSIVE DISORDER | MESOLIMBIC DOPAMINE | Depression - physiopathology | Maze Learning - physiology | Ventral Tegmental Area - physiopathology | Rats | Male | Motor Activity | Rats, Sprague-Dawley | Basal Forebrain - physiopathology | Animals | Basolateral Nuclear Complex - physiopathology | Dopaminergic Neurons - physiology | Neural Pathways - physiopathology | Stress, Psychological - physiopathology | Depression, Mental | Dopamine
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3. Full Text Unpredictable chronic mild stress not chronic restraint stress induces depressive behaviours in mice
by Zhu, Shenghua and Shi, Ruoyang and Wang, Junhui and Wang, Jun-Feng and Li, Xin-Min
NeuroReport, ISSN 0959-4965, 10/2014, Volume 25, Issue 14, pp. 1151 - 1155
The chronic stress model was developed on the basis of the stress–diathesis hypothesis of depression. However, these behavioural responses associated with... 
unpredictable chronic mild stress | anxiety | chronic restraint stress | depression | MODELS | RATS | NEUROSCIENCES | Motor Activity - physiology | Uncertainty | Mice, Inbred C57BL | Anxiety - physiopathology | Depressive Disorder - etiology | Animals | Depressive Disorder - physiopathology | Dietary Sucrose - administration & dosage | Female | Restraint, Physical | Psychological Tests | Drinking Behavior - physiology | Chronic Disease | Anxiety - etiology | Stress, Psychological - complications | Disease Models, Animal | Stress, Psychological - physiopathology
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4. Full Text Icariin exerts an antidepressant effect in an unpredictable chronic mild stress model of depression in rats and is associated with the regulation of hippocampal neuroinflammation
by Liu, B and Xu, C and Wu, X and Liu, F and Du, Y and Sun, J and Tao, J and Dong, J
Neuroscience, ISSN 0306-4522, 2015, Volume 294, pp. 193 - 205
Highlights • CMS procedure induced hippocampal NLRP3 inflammasome activation in rats. • Chronic icariin treatment ameliorated depression-like behaviors in the... 
Neurology | unpredictable chronic mild stress | icariin | depression | hippocampus | NLRP3 inflammasome | Unpredictable chronic mild stress | Icariin | Depression | Hippocampus | OXIDATIVE STRESS | ANTIOXIDANTS | INFLAMMASOME ACTIVATION | MEMORY DEFICITS | THERAPEUTIC IMPLICATIONS | CYTOKINE | KAPPA-B | NEUROSCIENCES | PSYCHIATRIC-DISORDERS | MICE | Depressive Disorder - drug therapy | NF-kappa B - metabolism | Hippocampus - drug effects | Rats, Sprague-Dawley | Blood-Brain Barrier - metabolism | Hippocampus - metabolism | Animals | Inflammasomes - drug effects | Antidepressive Agents - pharmacology | Flavonoids - pharmacology | Stress, Psychological - complications | Disease Models, Animal | Antidepressants | Depression, Mental
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5. Full Text Is unpredictable chronic mild stress (UCMS) a reliable model to study depression-induced neuroinflammation?
by Farooq, Rai Khalid and Isingrini, Elsa and Tanti, Arnaud and Le Guisquet, Anne-Marie and Arlicot, Nicolas and Minier, Frederic and Leman, Samuel and Chalon, Sylvie and Belzung, Catherine and Camus, Vincent
Behavioural Brain Research, ISSN 0166-4328, 05/2012, Volume 231, Issue 1, pp. 130 - 137
â–º Major depressive disorder is strongly associated with neuroinflammatory disorders. â–º We used an animal model of depression for validation to study... 
Neuroinflammation | Depression | Neurodegeneration | Animal model of depression | Microglial activation | Unpredictable chronic mild stress (UCMS) | CYTOKINES | METAANALYSIS | SICKNESS BEHAVIOR | MAJOR DEPRESSION | NEUROSCIENCES | INDUCED MICROGLIAL ACTIVATION | DISEASE | BEHAVIORAL SCIENCES | INFLAMMATORY RESPONSE | HIPPOCAMPAL NEUROGENESIS | BRAIN | REQUIREMENT | Depression, Mental | Models
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6. Full Text Effects of unpredictable chronic mild stress on anxiety and depression-like behavior in mice
by Mineur, Yann S and Belzung, Catherine and Crusio, Wim E
Behavioural Brain Research, ISSN 0166-4328, 2006, Volume 175, Issue 1, pp. 43 - 50
The widely accepted stress-diathesis hypothesis of depression postulates that genetic factors contribute to biological vulnerability. Based on this concept,... 
Unpredictable chronic mild stress | Mouse | Inbred strain | Depression | Anxiety | Startle reflex | Behavioral despair | Locomotor activity | INBRED MOUSE STRAINS | startle reflex | ANTIDEPRESSANT | ANTAGONIST | inbred strain | ENVIRONMENT | behavioral despair | MODEL | ELEVATED PLUS-MAZE | NEUROSCIENCES | anxiety | mouse | TAIL-SUSPENSION TEST | STARTLE RESPONSE | unpredictable chronic mild stress | SUCROSE PREFERENCE | BEHAVIORAL SCIENCES | locomotor activity | depression | MODULATION | Species Specificity | Male | Reaction Time | Mice, Inbred Strains | Hindlimb Suspension - physiology | Behavior, Animal | Depression - etiology | Exploratory Behavior - physiology | Animals | Analysis of Variance | Sex Factors | Female | Mice | Swimming | Reflex, Startle - physiology | Anxiety - etiology | Stress, Psychological - complications | Stress, Psychological - etiology | Disease Models, Animal | Gene expression | Antidepressants | Depression, Mental | Analysis
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7. Full Text Sex differences in the chronic mild stress model of depression
by Franceschelli, Anthony and Herchick, Samantha and Thelen, Connor and Papadopoulou-Daifoti, Zeta and Pitychoutis, Pothitos M
Behavioural Pharmacology, ISSN 0955-8810, 09/2014, Volume 25, Issue 5 and 6, pp. 372 - 383
A large volume of clinical and experimental evidence documents sex differences in brain anatomy, chemistry, and function, as well as in stress and drug... 
mouse | serotonin | rat | anhedonia | unpredictable | female | chronic mild stress | major depression | sex differences | forced swim test | STAR-ASTERISK-D | PRENATAL ALCOHOL EXPOSURE | ANTIDEPRESSANT TREATMENT | CHRONIC VARIABLE STRESS | NEUROSCIENCES | CHRONIC RESTRAINT STRESS | CHRONIC UNPREDICTABLE STRESS | FEMALE RATS | STRAIN DIFFERENCES | SUCROSE PREFERENCE | BEHAVIORAL SCIENCES | PHARMACOLOGY & PHARMACY | ANIMAL-MODEL | Stress, Psychological - drug therapy | Brain - physiopathology | Humans | Depressive Disorder - drug therapy | Male | Sex Characteristics | Brain - drug effects | Animals | Depressive Disorder - physiopathology | Female | Chronic Disease | Disease Models, Animal | Stress, Psychological - physiopathology
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8. Full Text Chronic Mild Stress (CMS) Revisited: Consistency and Behavioural-Neurobiological Concordance in the Effects of CMS
by Willner, Paul
Neuropsychobiology, ISSN 0302-282X, 08/2005, Volume 52, Issue 2, pp. 90 - 110
The chronic mild stress (CMS) model of depression has high validity but has in the past been criticized for being difficult to replicate. However, a large... 
Review | Anhedonia | Chronic mild stress | Dopamine agonists | Antidepressants | Animal model of depression | CHRONIC ULTRAMILD STRESS | PSYCHIATRY | animal model of depression | antidepressants | FORCED SWIM TEST | dopamine agonists | CHRONIC VARIABLE STRESS | NEUROSCIENCES | RECEPTOR ANTAGONIST | SUCROSE CONSUMPTION | PSYCHOLOGY | BANXIA-HOUPU DECOCTION | CHRONIC UNPREDICTABLE STRESS | INDUCED ANHEDONIA MODEL | anhedonia | REALISTIC ANIMAL-MODEL | chronic mild stress | LONG-TERM TREATMENT | Food Preferences | Humans | Rats | Behavior, Animal - physiology | Stress, Physiological - physiopathology | Neurobiology - methods | Stress, Physiological - diagnosis | Brain Chemistry - physiology | Depression - etiology | Stress, Physiological - complications | Animals | Individuality | Mice | Reward | Disease Models, Animal
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9. Full Text Neuropsychopharmacological effect of sesamol in unpredictable chronic mild stress model of depression: behavioral and biochemical evidences
by Kumar, Baldeep and Kuhad, Anurag and Chopra, Kanwaljit
Psychopharmacology, ISSN 0033-3158, 4/2011, Volume 214, Issue 4, pp. 819 - 828
A complex relationship exists among stressful situations, body's reaction to stress, and the onset of clinical depression. Chronic unpredictable stressors can... 
Antidepressant | Neurosciences | Biomedicine | Unpredictable chronic stress | TNF-α | Depression | Sesamol | Pharmacology/Toxicology | Psychiatry | Stress | LIPID-PEROXIDATION | TNF-alpha | PSYCHIATRY | NITRIC-OXIDE SYNTHASE | ANTIDEPRESSANT TREATMENTS | MAJOR DEPRESSION | CHRONIC VARIABLE STRESS | NEUROSCIENCES | INDUCED OXIDATIVE STRESS | PHARMACOLOGY & PHARMACY | ANIMAL-MODEL | RAT HIPPOCAMPUS | INDUCED ANHEDONIA | PITUITARY-ADRENAL AXIS | Brain - enzymology | Motor Activity - drug effects | Male | Stress, Psychological - psychology | Brain - metabolism | Depression - drug therapy | Depression - metabolism | Stress, Psychological - metabolism | Lipid Peroxidation - drug effects | Behavior, Animal - drug effects | Antidepressive Agents - pharmacology | Benzodioxoles - therapeutic use | Disease Models, Animal | Phenols - pharmacology | Food Preferences - drug effects | Stress, Psychological - drug therapy | Mice, Inbred Strains | Antidepressive Agents - therapeutic use | Brain - drug effects | Animals | Phenols - therapeutic use | Psychopharmacology | Depression - psychology | Mice | Chronic Disease | Benzodioxoles - pharmacology | Antioxidants | Enzymes | Usage | Tumor necrosis factor | Analysis | Depression, Mental | Lipid peroxidation | Superoxide | Research | Antidepressants, Tricyclic | Biochemistry | Mental depression | Antidepressants
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10. Full Text Saikosaponin D relieves unpredictable chronic mild stress induced depressive-like behavior in rats: involvement of HPA axis and hippocampal neurogenesis
by Li, Hong-Yan and Zhao, Ying-Hua and Zeng, Min-Jie and Fang, Fang and Li, Min and Qin, Ting-Ting and Ye, Lu-Yu and Li, Hong-Wei and Qu, Rong and Ma, Shi-Ping
Psychopharmacology, ISSN 0033-3158, 11/2017, Volume 234, Issue 22, pp. 3385 - 3394
Saikosaponin D (SSD), a major bioactive component isolated from Radix Bupleuri, has been reported to exert neuroprotective properties.The present study was... 
Unpredictable chronic mild stress | Neurosciences | Biomedicine | Saikosaponin D | Depression | Hypothalamic-pituitary-adrenal axis | Hippocampal neurogenesis | Pharmacology/Toxicology | Psychiatry | Neurotrophic molecules | PSYCHIATRY | NEUROTROPHIC FACTOR | ANTIDEPRESSANT TREATMENT | ELEMENT-BINDING PROTEIN | FORCED SWIM TEST | MAJOR DEPRESSION | MODEL | NEUROSCIENCES | FLUOXETINE TREATMENT | PHARMACOLOGY & PHARMACY | GLUCOCORTICOID-RECEPTOR PHOSPHORYLATION | EXPRESSION | BRAIN | Depression - physiopathology | Oleanolic Acid - analogs & derivatives | Oleanolic Acid - pharmacology | Male | Hippocampus - drug effects | Stress, Psychological - psychology | Arousal - drug effects | Motivation - drug effects | Antidepressive Agents - pharmacology | Neurogenesis - drug effects | Corticosterone - blood | Phytotherapy | Receptors, Glucocorticoid - drug effects | Hypothalamo-Hypophyseal System - physiopathology | Hypothalamo-Hypophyseal System - drug effects | Pituitary-Adrenal System - physiopathology | Pituitary-Adrenal System - drug effects | Rats | Rats, Sprague-Dawley | Arousal - physiology | Animals | Motivation - physiology | Neurogenesis - physiology | Depression - psychology | Hippocampus - physiopathology | Receptors, Glucocorticoid - physiology | Saponins - pharmacology | Stress, Psychological - physiopathology | Prevention | Saponins | Hippocampus (Brain) | Health aspects | Neurogenesis | Depression, Mental | Immunohistochemistry | Neuroprotection | Brain | Sucrose | Glucocorticoids | Corticosterone | P elements | Body weight | Hypothalamus | Consolidation | Antidepressants | Rodents | Doublecortin protein | Sugars | Open-field behavior | Translocation | Cyclic AMP response element-binding protein | Nuclear transport | Studies | Brain-derived neurotrophic factor | Pituitary | Weight reduction | Hippocampus
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