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1. Full Text Synthesis and Structure−Activity Relationships of Uracil Nucleotide Derivatives and Analogues as Agonists at Human P2Y2, P2Y4, and P2Y6 Receptors
by El-Tayeb, Ali and Qi, Aidong and Müller, Christa E
Journal of Medicinal Chemistry, ISSN 0022-2623, 11/2006, Volume 49, Issue 24, pp. 7076 - 7087
A series of UTP, UDP, and UMP derivatives and analogues were synthesized and evaluated at the human pyrimidinergic P2Y receptor subtypes P2Y2, P2Y4, and P2Y6... 
Purines - chemical synthesis | Bridged Bicyclo Compounds - chemical synthesis | Inositol Phosphates - biosynthesis | Receptors, Purinergic P2 | Bridged Bicyclo Compounds - pharmacology | Uridine Diphosphate - analogs & derivatives | Purines - pharmacology | Humans | Uridine Triphosphate - pharmacology | Purinergic P2 Receptor Agonists | Receptors, Purinergic P2Y2 | Structure-Activity Relationship | Uracil Nucleotides - pharmacology | Uridine Diphosphate - chemical synthesis | Uracil Nucleotides - chemical synthesis | Uridine Triphosphate - analogs & derivatives | Uridine Monophosphate - pharmacology | Uridine Monophosphate - analogs & derivatives | Cell Line, Tumor | Uridine Diphosphate - pharmacology | Uridine Triphosphate - chemical synthesis | Uridine Monophosphate - chemical synthesis
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2. Étude de la glucuroconjugaison hépatique
: Thèse méd
by Madarász, Zoltán
1973, 18
Uridine diphosphoglucuronosyltransferase
Book
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3. Full Text Efficient one-pot multienzyme synthesis of UDP-sugars using a promiscuous UDP-sugar pyrophosphorylase from Bifidobacterium longum (BLUSP)
by Muthana, Musleh M and Qu, Jingyao and Li, Yanhong and Zhang, Lei and Yu, Hai and Ding, Li and Malekan, Hamed and Chen, Xi
Chemical Communications, ISSN 1359-7345, 03/2012, Volume 48, Issue 21, pp. 2728 - 2730
A promiscuous UDP-sugar pyrophosphorylase (BLUSP) was cloned from Bifidobacterium longum strain ATCC55813 and used efficiently with a Pasteurella multocida... 
TEICHOIC-ACIDS | BROAD SUBSTRATE-SPECIFICITY | BACILLUS-SUBTILIS | GALACTOSE PYROPHOSPHORYLASE | CHEMOENZYMATIC SYNTHESIS | BIOSYNTHESIS | REGENERATION | PURIFICATION | N-ACETYLLACTOSAMINE | CHEMISTRY, MULTIDISCIPLINARY | ESCHERICHIA-COLI GALACTOKINASE | Uridine Diphosphate Glucose - biosynthesis | Galactokinase - metabolism | Uridine Diphosphate Galactose - chemistry | Uridine Diphosphate Glucose - chemistry | Pasteurella multocida - enzymology | Uridine Diphosphate Sugars - biosynthesis | Bifidobacterium - enzymology | Inorganic Pyrophosphatase - metabolism | UTP-Glucose-1-Phosphate Uridylyltransferase - metabolism | Uridine Diphosphate Galactose - biosynthesis | Uridine Diphosphate Sugars - chemistry | Chemical communication
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4. Full Text Efficient chemoenzymatic synthesis of uridine 5′-diphosphate N-acetylglucosamine and uridine 5′-diphosphate N-trifluoacetyl glucosamine with three recombinant enzymes
by Li, Xiaoyan and Qi, Chen and Wei, Peilian and Huang, Lei and Cai, Jin and Xu, Zhinan
Preparative Biochemistry and Biotechnology, ISSN 1082-6068, 10/2017, Volume 47, Issue 9, pp. 852 - 859
Uridine 5′-diphosphate N-acetylglucosamine (UDP-GlcNAc) is a natural UDP-monosaccharide donor for bacterial glycosyltransferases, while uridine 5′-diphosphate... 
uridine 5′-diphosphate N-acetylglucosamine | N-acetylglucosamine-1-phosphate uridyltransferase | Biosynthesis | one-pot system | uridine 5′-diphosphate N-trifluoacetyl glucosamine | N-acetylhexosamine 1-kinase | uridine 5-diphosphate N-trifluoacetyl glucosamine | ROUTE | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | BIOCHEMICAL RESEARCH METHODS | ACETYLHEXOSAMINE 1-KINASE | SCALE SYNTHESIS | PHOSPHATE | 5-DIPHOSPHO-N-ACETYLGLUCOSAMINE | uridine 5-diphosphate N-acetylglucosamine | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | SUBSTRATE | HEPARAN-SULFATE | Phosphotransferases - metabolism | Lactobacillus - genetics | Uridine Diphosphate - analogs & derivatives | Inorganic Pyrophosphatase - metabolism | Acetylglucosamine - metabolism | Enterococcus - enzymology | Bifidobacterium - metabolism | Cloning, Molecular | Escherichia coli - metabolism | Acetylglucosamine - analogs & derivatives | Nucleotidyltransferases - metabolism | Uridine Diphosphate N-Acetylglucosamine - genetics | Lactobacillus - enzymology | Phosphotransferases - genetics | Uridine Diphosphate N-Acetylglucosamine - metabolism | Recombinant Proteins - metabolism | Escherichia coli - enzymology | Bifidobacterium - genetics | Uridine Diphosphate - genetics | Biosynthetic Pathways | Recombinant Proteins - genetics | Acetylglucosamine - genetics | Lactobacillus - metabolism | Uridine Diphosphate - metabolism | Inorganic Pyrophosphatase - genetics | Escherichia coli - genetics | Nucleotidyltransferases - genetics | Bifidobacterium - enzymology | Enterococcus - metabolism | Enterococcus - genetics | Phosphates | Enzymes | Glucosamine | N-Acetylglucosamine | Substrate inhibition | Kinases | Inorganic pyrophosphatase | Synthesis | E coli | N-Acetylglucosamine-1-phosphate uridyltransferase | Bioreactors | Fed batch | Uridine | Bacteria | N-Acetylglucosamine-1-phosphate | Pyrophosphatase | Recombinant
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5. Full Text Ledipasvir and Sofosbuvir for Previously Treated HCV Genotype 1 Infection
by Afdhal, Nezam and Reddy, K. Rajender and Nelson, David R and Lawitz, Eric and Gordon, Stuart C and Schiff, Eugene and Nahass, Ronald and Ghalib, Reem and Gitlin, Norman and Herring, Robert and Lalezari, Jacob and Younes, Ziad H and Pockros, Paul J and Di Bisceglie, Adrian M and Arora, Sanjeev and Subramanian, G. Mani and Zhu, Yanni and Dvory-Sobol, Hadas and Yang, Jenny C and Pang, Phillip S and Symonds, William T and McHutchison, John G and Muir, Andrew J and Sulkowski, Mark and Kwo, Paul and ION-2 Investigators
The New England Journal of Medicine, ISSN 0028-4793, 04/2014, Volume 370, Issue 16, pp. 1483 - 1493
In this study in patients with HCV genotype 1 infection and prior treatment failure, those assigned to 12 weeks or 24 weeks of treatment with ledipasvir and... 
NS5A INHIBITOR | MEDICINE, GENERAL & INTERNAL | TREATMENT-NAIVE | C VIRUS-INFECTION | RIBAVIRIN | HEPATITIS-C | PLUS | Uridine Monophosphate - administration & dosage | Humans | Middle Aged | Fluorenes - therapeutic use | Hepacivirus - genetics | Hepatitis C, Chronic - virology | Male | RNA Replicase - antagonists & inhibitors | Viral Load | Benzimidazoles - administration & dosage | Adult | Female | Fluorenes - administration & dosage | Nucleotidyltransferases - antagonists & inhibitors | Fluorenes - adverse effects | Uridine Monophosphate - adverse effects | Benzimidazoles - adverse effects | Benzimidazoles - therapeutic use | Uridine Monophosphate - therapeutic use | Antiviral Agents - therapeutic use | Genotype | Hepatitis C, Chronic - drug therapy | Antiviral Agents - adverse effects | Uridine Monophosphate - analogs & derivatives | Aged | Viral Nonstructural Proteins - antagonists & inhibitors | Drug Combinations | Sofosbuvir | Hepatitis C | Drug therapy | Research | Headache | Fatigue | Infections | Nausea | Proteinase inhibitors | FDA approval | Patients | Ribavirin | Cirrhosis | Genotype & phenotype | Hepatitis | Interferon | Genotypes
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6. Sofosbuvir: First global approval
by Keating, Gillian M and Vaidya, Asha
Drugs, ISSN 0012-6667, 2014, Volume 74, Issue 2, pp. 273 - 282
Sofosbuvir (Solvadi (TM)), a nucleotide analogue hepatitis C virus NS5B polymerase inhibitor, is under development with Gilead Sciences for the once-daily,... 
HIGH SVR RATES | HEPATITIS-C INFECTION | HCV GENOTYPE 1-6 | PLUS RIBAVIRIN | IN-VITRO | LIVER-TRANSPLANTATION | PHARMACOLOGY & PHARMACY | TOXICOLOGY | HEALTHY-VOLUNTEERS | TREATMENT-NAIVE PATIENTS | DRUG-DRUG INTERACTION | PHASE-2 TRIAL | Uridine Monophosphate - administration & dosage | Antiviral Agents - pharmacology | Antiviral Agents - pharmacokinetics | Viral Nonstructural Proteins - drug effects | Antiviral Agents - therapeutic use | Humans | Hepatitis C, Chronic - drug therapy | Antiviral Agents - administration & dosage | Uridine Monophosphate - pharmacology | Antiviral Agents - adverse effects | Uridine Monophosphate - analogs & derivatives | Uridine Monophosphate - adverse effects | Uridine Monophosphate - pharmacokinetics | Drug Therapy, Combination | Sofosbuvir | Uridine Monophosphate - therapeutic use
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7. Full Text The discovery of IDX21437: Design, synthesis and antiviral evaluation of 2′-α-chloro-2′-β-C-methyl branched uridine pronucleotides as potent liver-targeted HCV polymerase inhibitors
by Alexandre, François-René and Badaroux, Eric and Bilello, John P and Bot, Stéphanie and Bouisset, Tony and Brandt, Guillaume and Cappelle, Sylvie and Chapron, Christopher and Chaves, Dominique and Convard, Thierry and Counor, Clément and Da Costa, Daniel and Dukhan, David and Gay, Marion and Gosselin, Gilles and Griffon, Jean-François and Gupta, Kusum and Hernandez-Santiago, Brenda and La Colla, Massimiliano and Lioure, Marie-Pierre and Milhau, Julien and Paparin, Jean-Laurent and Peyronnet, Jérôme and Parsy, Christophe and Pierra Rouvière, Claire and Rahali, Houcine and Rahali, Rachid and Salanson, Aurélien and Seifer, Maria and Serra, Ilaria and Standring, David and Surleraux, Dominique and Dousson, Cyril B
Bioorganic & Medicinal Chemistry Letters, ISSN 0960-894X, 09/2017, Volume 27, Issue 18, pp. 4323 - 4330
Herein we describe the discovery of IDX21437 , a novel -aminoacid-based phosphoramidate prodrug of 2′-α-chloro-2′-β- -methyluridine monophosphate. Its... 
Pronucleotide | HCV NS5B polymerase inhibitors | Synthesis and biological evaluation | Nucleoside | Hepatitis C | Liver delivery | PSI-7977 | CHEMISTRY, MEDICINAL | 2'-C-METHYLCYTIDINE | CHEMISTRY, ORGANIC | METABOLIC-ACTIVATION | PHOSPHATE | THERAPY | HEPATITIS-C VIRUS | NUCLEOTIDE PRODRUGS | INFECTION | Liver - virology | DNA-Directed RNA Polymerases - antagonists & inhibitors | Humans | Uridine Monophosphate - chemistry | Structure-Activity Relationship | Enzyme Inhibitors - chemical synthesis | Dose-Response Relationship, Drug | Microbial Sensitivity Tests | Liver - drug effects | Antiviral Agents - chemistry | Enzyme Inhibitors - chemistry | Molecular Structure | Hepatocytes - drug effects | Uridine - chemistry | Uridine Monophosphate - chemical synthesis | Hepacivirus - drug effects | Antiviral Agents - pharmacology | Enzyme Inhibitors - pharmacology | Drug Discovery | Uridine - pharmacology | Uridine Monophosphate - pharmacology | Hepacivirus - enzymology | Animals | Uridine Monophosphate - analogs & derivatives | Antiviral Agents - chemical synthesis | Hepatocytes - virology | Viral Nonstructural Proteins - metabolism | Mice | DNA-Directed RNA Polymerases - metabolism | Viral Nonstructural Proteins - antagonists & inhibitors | Uridine - chemical synthesis | Index Medicus
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8. Full Text A Potent, Covalent Inhibitor of Orotidine 5‘-Monophosphate Decarboxylase with Antimalarial Activity
by Bello, Angelica M and Poduch, Ewa and Fujihashi, Masahiro and Amani, Merhnaz and Li, Yan and Crandall, Ian and Hui, Raymond and Lee, Ping I and Kain, Kevin C and Pai, Emil F and Kotra, Lakshmi P
Journal of Medicinal Chemistry, ISSN 0022-2623, 03/2007, Volume 50, Issue 5, pp. 915 - 921
Orotidine 5‘-monophosphate decarboxylase (ODCase) has evolved to catalyze the decarboxylation of orotidine 5‘-monophosphate without any covalent intermediates.... 
CONTACTS | CHEMISTRY, MEDICINAL | ENZYME | NUCLEOTIDE BIOSYNTHESIS | GROUND-STATE | MECHANISM | C-6 POSITION | CATALYTIC PROFICIENCY | TRANSITION-STATE | PYRIMIDINE BIOSYNTHESIS | URIDINE | Plasmodium falciparum - enzymology | Cricetulus | Orotidine-5'-Phosphate Decarboxylase - antagonists & inhibitors | Stereoisomerism | Uridine - analogs & derivatives | Uridine Monophosphate - chemistry | Crystallography, X-Ray | Structure-Activity Relationship | Plasmodium falciparum - drug effects | Methanobacterium - enzymology | Mass Spectrometry | Plasmodium falciparum - isolation & purification | Antimalarials - chemical synthesis | Uridine - chemistry | CHO Cells | Uridine Monophosphate - chemical synthesis | Cricetinae | Models, Molecular | Uridine - pharmacology | Antimalarials - pharmacology | Uridine Monophosphate - pharmacology | Animals | Orotidine-5'-Phosphate Decarboxylase - chemistry | Uridine Monophosphate - analogs & derivatives | Antimalarials - chemistry | Uridine - chemical synthesis
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9. Full Text Ledipasvir and Sofosbuvir for HCV in Patients Coinfected with HIV-1
by Naggie, Susanna and Cooper, Curtis and Saag, Michael and Workowski, Kimberly and Ruane, Peter and Towner, William J and Marks, Kristen and Luetkemeyer, Anne and Baden, Rachel P and Sax, Paul E and Gane, Edward and Santana-Bagur, Jorge and Stamm, Luisa M and Yang, Jenny C and German, Polina and Dvory-Sobol, Hadas and Ni, Liyun and Pang, Phillip S and McHutchison, John G and Stedman, Catherine A.M and Morales-Ramirez, Javier O and Bräu, Norbert and Jayaweera, Dushyantha and Colson, Amy E and Tebas, Pablo and Wong, David K and Dieterich, Douglas and Sulkowski, Mark and ION-4 Investigators
The New England Journal of Medicine, ISSN 0028-4793, 08/2015, Volume 373, Issue 8, pp. 705 - 713
Among patients coinfected with HIV-1 and HCV genotype 1 or 4 who were receiving effective antiretroviral therapy, treatment with 12 weeks of ledipasvir and... 
MEDICINE, GENERAL & INTERNAL | HEPATOCELLULAR-CARCINOMA | INTERFERON | THERAPY | HEPATITIS-C VIRUS | CIRRHOSIS | ALPHA-2A PLUS RIBAVIRIN | VETERANS | GENOTYPE 1 INFECTION | COHORT | LIVER-DISEASE | HIV-1 | Humans | Middle Aged | Drug Resistance, Viral | Fluorenes - therapeutic use | Hepacivirus - genetics | Male | RNA, Viral - blood | Hepatitis C, Chronic - complications | Viral Load | Female | Fluorenes - adverse effects | Uridine Monophosphate - adverse effects | Benzimidazoles - adverse effects | Drug Therapy, Combination | Benzimidazoles - therapeutic use | Uridine Monophosphate - therapeutic use | Hepacivirus - drug effects | Fluorenes - pharmacokinetics | Hepacivirus - isolation & purification | Anti-Retroviral Agents - therapeutic use | Antiviral Agents - therapeutic use | Benzimidazoles - pharmacokinetics | Genotype | Hepatitis C, Chronic - drug therapy | Antiviral Agents - adverse effects | Uridine Monophosphate - analogs & derivatives | HIV Infections - complications | HIV Infections - drug therapy | Uridine Monophosphate - pharmacokinetics | Sofosbuvir | Care and treatment | Research | Hepatitis C virus | HIV infection | Emtricitabine | Headache | Antiretroviral drugs | Inhibitor drugs | Diarrhea | Fatigue | Patients | Efavirenz | Studies | Tenofovir | Cirrhosis | Genotype & phenotype | Hepatitis | Human immunodeficiency virus--HIV | Hepatitis C | Drug therapy | Genotypes
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10. Full Text Sofosbuvir and Ribavirin for Hepatitis C Genotype 1 in Patients With Unfavorable Treatment Characteristics: A Randomized Clinical Trial
by Osinusi, Anuoluwapo and Meissner, Eric G and Lee, Yu-Jin and Bon, Dimitra and Heytens, Laura and Nelson, Amy and Sneller, Michael and Kohli, Anita and Barrett, Lisa and Proschan, Michael and Herrmann, Eva and Shivakumar, Bhavana and Gu, Wenjuan and Kwan, Richard and Teferi, Geb and Talwani, Rohit and Silk, Rachel and Kotb, Colleen and Wroblewski, Susan and Fishbein, Dawn and Dewar, Robin and Highbarger, Helene and Zhang, Xiao and Kleiner, David and Wood, Brad J and Chavez, Jose and Symonds, William T and Subramanian, Mani and McHutchison, John and Polis, Michael A and Fauci, Anthony S and Masur, Henry and Kottilil, Shyamasundaran
JAMA, ISSN 0098-7484, 08/2013, Volume 310, Issue 8, pp. 804 - 811
IMPORTANCE The efficacy of directly acting antiviral agents in interferon-free regimens for the treatment of chronic hepatitis C infections needs to be... 
UNITED-STATES | MEDICINE, GENERAL & INTERNAL | PLUS RIBAVIRIN | PLACEBO | VIRUS-INFECTION | TELAPREVIR | ANTIVIRAL THERAPY | PEGYLATED INTERFERON | BOCEPREVIR | PREVALENCE | COMBINATION | Uridine Monophosphate - administration & dosage | Body Weight | Prognosis | Antiviral Agents - pharmacokinetics | Hepatitis C - drug therapy | Humans | Middle Aged | Hepacivirus - genetics | Male | Viral Load | Interleukins - genetics | Ribavirin - administration & dosage | Ribavirin - pharmacokinetics | Female | Uridine Monophosphate - adverse effects | Hepacivirus - isolation & purification | Hepatitis C - genetics | Treatment Outcome | Antiviral Agents - administration & dosage | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Uridine Monophosphate - analogs & derivatives | Hepacivirus - classification | Uridine Monophosphate - pharmacokinetics | Sofosbuvir | Patient safety | Clinical trials | Hepatitis | Side effects | Weight
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11. Full Text Uridine homeostatic disorder leads to DNA damage and tumorigenesis
by Cao, Zhe and Ma, Jun and Chen, Xinchun and Zhou, Boping and Cai, Chuan and Huang, Dan and Zhang, Xuewen and Cao, Deliang
Cancer Letters, ISSN 0304-3835, 2016, Volume 372, Issue 2, pp. 219 - 225
Highlights • Uridine homeostatic disorder induced by uridine phosphorylase knockout leads to DNA damage and spontaneous tumorigenesis. • Addition of uridine... 
Hematology, Oncology and Palliative Medicine | Uridine homeostasis | UPase knockout | Uracil DNA damage | Uridine phosphorylase | Carcinogenesis | p53 | P53 | HIGH-DOSE URIDINE | PHOSPHORYLASE GENE | CELLS | DEPENDENT PROTEIN-KINASE | ACID SYNTHESIS | URACIL | IDENTIFICATION | METABOLISM | ONCOLOGY | BIOSYNTHESIS | Neoplasms - metabolism | Up-Regulation | Phosphorylation | Neoplasms - etiology | Uridine Phosphorylase - deficiency | Humans | Homeostasis | Dose-Response Relationship, Drug | MCF-7 Cells | Neoplasms - genetics | Time Factors | Cell Transformation, Neoplastic - genetics | Uridine - toxicity | Uridine Phosphorylase - genetics | Tumor Suppressor Protein p53 - metabolism | Genotype | Cell Transformation, Neoplastic - metabolism | Mice, Knockout | Phenotype | Animals | Uracil - metabolism | Uridine - metabolism | DNA Damage | Cell Transformation, Neoplastic - pathology | Neoplasms - pathology | Tumor proteins | DNA damage | DNA | Tumors | Plasma | Diabetic neuropathy | Biosynthesis | Kinases | Metabolism | Mammals | Proteins | Human subjects | Nutrition research | Carcinogens | Metabolites | Rodents | Accreditation | Tumorigenesis | Alzheimers disease | Deoxyribonucleic acid--DNA | Index Medicus
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12. Full Text Substrate specificity of E. coli uridine phosphorylase. Further evidences of high-syn conformation of the substrate in uridine phosphorolysis
by Alexeev, C. S and Sivets, G. G and Safonova, T. N and Mikhailov, S. N and Mikhailov, S. N
Nucleosides, Nucleotides and Nucleic Acids, ISSN 1525-7770, 02/2017, Volume 36, Issue 2, pp. 107 - 121
Twenty five uridine analogues have been tested and compared with uridine with respect to their potency to bind to E. coli uridine phosphorylase. The kinetic... 
modified uridines | Uridine phosphorylase | substrate specificity | conformation of uridine | PENTOSE MOIETY | PURINE-NUCLEOSIDE PHOSPHORYLASE | LIGANDS | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | DERIVATIVES | BINDING | Catalytic Domain | Models, Molecular | Substrate Specificity | Crystallography, X-Ray | Escherichia coli Proteins - metabolism | Hydrogen Bonding | Uridine Phosphorylase - metabolism | Protein Conformation | Uridine - metabolism | Uridine Phosphorylase - chemistry | Kinetics | Escherichia coli Proteins - chemistry | Uridine - chemistry | Enzymes | E coli | Substrate specificity | Uridine | Thymidine | Hydrogen bonding | Sugar | Thymidine phosphorylase | Phosphorylase | Conformation
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13. Full Text Discovery of a β-d-2′-Deoxy-2′-α-fluoro-2′-β-C-methyluridine Nucleotide Prodrug (PSI-7977) for the Treatment of Hepatitis C Virus
by Sofia, Michael J and Bao, Donghui and Chang, Wonsuk and Du, Jinfa and Nagarathnam, Dhanapalan and Rachakonda, Suguna and Reddy, P. Ganapati and Ross, Bruce S and Wang, Peiyuan and Zhang, Hai-Ren and Bansal, Shalini and Espiritu, Christine and Keilman, Meg and Lam, Angela M and Steuer, Holly M. Micolochick and Niu, Congrong and Otto, Michael J and Furman, Phillip A
Journal of Medicinal Chemistry, ISSN 0022-2623, 10/2010, Volume 53, Issue 19, pp. 7202 - 7218
Hepatitis C virus (HCV) is a global health problem requiring novel approaches for effective treatment of this disease. The HCV NS5B polymerase has been... 
GENETIC DIVERSITY | POTENT INHIBITOR | NS5B POLYMERASE INHIBITORS | IN-VITRO | BETA-D-2'-DEOXY-2'-FLUORO-2'-C-METHYLCYTIDINE | ACTIVATION | CHEMISTRY, MEDICINAL | REPLICATION | ANTIVIRAL ACTIVITY | PHOSPHORAMIDATE DERIVATIVES | RNA-POLYMERASE | Antiviral Agents - pharmacokinetics | Stereoisomerism | Humans | Drug Resistance, Viral | Hepacivirus - genetics | Macaca fascicularis | Crystallography, X-Ray | Esters | Structure-Activity Relationship | Hepatocytes - metabolism | Uridine Monophosphate - chemical synthesis | Hepacivirus - drug effects | Cell Line | Antiviral Agents - pharmacology | Liver - metabolism | Rats | Viral Nonstructural Proteins - genetics | Uridine Monophosphate - pharmacology | Animals | Prodrugs - pharmacokinetics | Uridine Monophosphate - analogs & derivatives | Dogs | Antiviral Agents - chemical synthesis | Prodrugs - chemical synthesis | Uridine Monophosphate - pharmacokinetics | Mutation | In Vitro Techniques | Viral Nonstructural Proteins - antagonists & inhibitors | Prodrugs - pharmacology | Sofosbuvir | Replicon
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14. Full Text Sofosbuvir and Ribavirin for Treatment of Compensated Recurrent Hepatitis C Virus Infection After Liver Transplantation
by Charlton, Michael and Gane, Edward and Manns, Michael P and Brown, Robert S and Curry, Michael P and Kwo, Paul Y and Fontana, Robert J and Gilroy, Richard and Teperman, Lewis and Muir, Andrew J and McHutchison, John G and Symonds, William T and Brainard, Diana and Kirby, Brian and Dvory-Sobol, Hadas and Denning, Jill and Arterburn, Sarah and Samuel, Didier and Forns, Xavier and Terrault, Norah A
Gastroenterology, ISSN 0016-5085, 2015, Volume 148, Issue 1, pp. 108 - 117
Background & Aims Interferon alfa–based regimens used to treat recurrent hepatitis C virus (HCV) infection after liver transplantation are poorly tolerated,... 
Gastroenterology and Hepatology | Antiviral Agent | Clinical Trial | DAA | NS5B Polymerase Inhibitor | PLUS RIBAVIRIN | ANTIVIRAL THERAPY | EFFICACY | HCV GENOTYPE 1 | MULTICENTER EXPERIENCE | COMBINATION | RECIPIENTS | PEGYLATED INTERFERON | GRAFT-SURVIVAL | GASTROENTEROLOGY & HEPATOLOGY | DRUG-DRUG INTERACTIONS | Recurrence | Prospective Studies | Antiviral Agents - pharmacokinetics | Hepatitis C - drug therapy | Liver Transplantation - adverse effects | United States | Humans | Drug Resistance, Viral | Hepacivirus - genetics | Hepacivirus - pathogenicity | Male | RNA, Viral - blood | Viral Load | Time Factors | Ribavirin - pharmacokinetics | Female | Hepatitis C - complications | Uridine Monophosphate - adverse effects | Drug Therapy, Combination | Uridine Monophosphate - therapeutic use | Hepacivirus - drug effects | Liver Neoplasms - virology | Liver Cirrhosis - diagnosis | Antiviral Agents - therapeutic use | Carcinoma, Hepatocellular - diagnosis | Ribavirin - therapeutic use | Carcinoma, Hepatocellular - surgery | Genotype | Liver Neoplasms - surgery | Treatment Outcome | Carcinoma, Hepatocellular - virology | Biomarkers - blood | Spain | New Zealand | Hepatitis C - diagnosis | Pilot Projects | Liver Cirrhosis - virology | Liver Neoplasms - diagnosis | Ribavirin - adverse effects | Antiviral Agents - adverse effects | Uridine Monophosphate - analogs & derivatives | Liver Cirrhosis - surgery | Uridine Monophosphate - pharmacokinetics | Sofosbuvir | Virus diseases | Relapse | Liver | Transplantation | Biological response modifiers | Drug therapy | Hepatitis C virus | Health aspects | Immunosuppressive agents | Ribavirin | Diseases
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15. Full Text Optimised chemical synthesis of 5-substituted UDP-sugars and their evaluation as glycosyltransferase inhibitors
by Tedaldi, Lauren M and Pierce, Michael and Wagner, Gerd K
Carbohydrate Research, ISSN 0008-6215, 12/2012, Volume 364, pp. 22 - 27
► An optimised chemical synthesis for 5-substituted UDP-sugars was developed. ► NMICl was found to be the optimal promoter for pyrophosphate bond formation. ►... 
Glycosyltransferase inhibitors | 5-Iodouridine diphosphosugars | Sugar-nucleotides | N-Methylimidazolium chloride | Pyrophosphate bond | ANALOGS | BIOCHEMISTRY & MOLECULAR BIOLOGY | GLYCANS | CHEMISTRY, ORGANIC | TRANSFERASES | CANCER | NUCLEOTIDES | GALACTOSYLTRANSFERASES | BIOSYNTHESIS | N-ACETYLGLUCOSAMINYLTRANSFERASE-V | CHEMISTRY, APPLIED | Uridine Diphosphate N-Acetylglucosamine - pharmacology | Uridine Diphosphate - analogs & derivatives | Solvents - chemistry | Enzyme Inhibitors - chemical synthesis | N-Acetylglucosaminyltransferases - chemistry | Uridine Diphosphate Galactose - pharmacology | Tetrazoles - chemistry | Time Factors | Enzyme Inhibitors - chemistry | Uridine Diphosphate N-Acetylglucosamine - chemical synthesis | CHO Cells | Galactosephosphates - chemistry | Cricetinae | Magnetic Resonance Spectroscopy | Uridine Diphosphate Galactose - chemical synthesis | Uridine Diphosphate Galactose - chemistry | Enzyme Inhibitors - pharmacology | Recombinant Proteins - chemistry | Enzyme Assays | Uridine Diphosphate - chemical synthesis | Uridine Diphosphate N-Acetylglucosamine - chemistry | Diphosphates - chemistry | Animals | N-Acetylglucosaminyltransferases - antagonists & inhibitors | Enzyme Activation | Phosphates | Chemical synthesis
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