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Circulation, ISSN 0009-7322, 07/2012, Volume 126, Issue 4, pp. 455 - 467
Background-Epigenetic programming, dynamically regulated by histone acetylation, is a key mechanism regulating cell proliferation and survival. Little is known... 
genetic | epigenesis | vorinostat | histone deacetylation | pulmonary | valproic acid | hypertension | TARGET | CELLS | APOPTOSIS | CARDIAC & CARDIOVASCULAR SYSTEMS | ACETYLATION | hypertension, pulmonary | epigenesis, genetic | PROLIFERATION | EMERGENCE | ARTERIAL-HYPERTENSION | PROSTATE-CANCER | IN-VIVO | PERIPHERAL VASCULAR DISEASE | HEMATOLOGY | EXPRESSION | Muscle, Smooth, Vascular - metabolism | Humans | Male | Valproic Acid - pharmacology | Pulmonary Artery - metabolism | Histone Deacetylase 1 - antagonists & inhibitors | Valproic Acid - therapeutic use | Hypertension, Pulmonary - drug therapy | Lung - metabolism | Hydroxamic Acids - pharmacology | Disease Models, Animal | Muscle, Smooth, Vascular - drug effects | Lung - pathology | Cells, Cultured | Rats | Histone Deacetylases - metabolism | Hypertension, Pulmonary - metabolism | Hypoxia - complications | Platelet-Derived Growth Factor - pharmacology | Pulmonary Artery - drug effects | Rats, Sprague-Dawley | Muscle, Smooth, Vascular - pathology | Animals | Lung - drug effects | Histone Deacetylase Inhibitors - pharmacology | Histone Deacetylases - drug effects | Hydroxamic Acids - therapeutic use | Cell Proliferation - drug effects | Histone Deacetylase Inhibitors - therapeutic use | Hypertension, Pulmonary - etiology | Pulmonary Artery - pathology | Histone Deacetylase 1 - metabolism | Cell proliferation | Divalproex | Care and treatment | Usage | Enzyme inhibitors | Physiological aspects | Research | Valproic acid | Health aspects | Pulmonary hypertension
Journal Article
Nuclear Medicine and Biology, ISSN 0969-8051, 2013, Volume 40, Issue 7, pp. 912 - 918
Abstract The fatty acids, n -butyric acid (BA), 4-phenylbutyric acid (PBA) and valproic acid (VPA, 2-propylpentanoic acid) have been used for many years in the... 
Radiology | Histone deacetylase (HDAC) | [11C]4-phenylbutyric acid | [11C]butyric acid | Pharmacokinetics | Positron emission tomography | 11C]valproic acid | C]4-phenylbutyric acid | C]butyric acid | C]valproic acid | BETA-GLOBIN DISORDERS | C-11]valproic acid | ULCERATIVE-COLITIS | [C-11]4-phenylbutyric acid | MEMORY | DISEASE MOUSE MODEL | SODIUM-BUTYRATE | IN-VIVO | PHENYLBUTYRATE | INCREASED FETAL-HEMOGLOBIN | HISTONE DEACETYLASE INHIBITORS | [C-11]butyric acid | RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING | COLONIC-MUCOSA | Phenylbutyrates - blood | Valproic Acid - pharmacokinetics | Brain - diagnostic imaging | Positron-Emission Tomography | Blood Proteins - metabolism | Histone Deacetylase Inhibitors - blood | Brain - metabolism | Papio | Tissue Distribution | Histone Deacetylase Inhibitors - pharmacokinetics | Animals | Butyric Acid - metabolism | Phenylbutyrates - pharmacokinetics | Phenylbutyrates - metabolism | Radiochemistry | Valproic Acid - blood | Butyric Acid - pharmacokinetics | Isotope Labeling | Female | Histone Deacetylase Inhibitors - metabolism | Butyric Acid - blood | Valproic Acid - metabolism | Carbon Radioisotopes | Drugs | Divalproex | Valproic acid | Saturated fatty acids | Organic acids | Index Medicus | RADIATION CHEMISTRY, RADIOCHEMISTRY, AND NUCLEAR CHEMISTRY | phamacokinetics | 11C (Carbon 11) | [11C]PBA (4-phenylbutyric acid) | PET (positron emission tomography) | HDAC (histone deacetylase) | [11C]VPA (valproic acid) | [11C]BA (butyric acid) | [11C]valproic acid | pharmacokinetics | carbon-11 | histone deacetylase (HDAC) | positron emission tomography
Journal Article
Journal Article
Neurology, ISSN 0028-3878, 2009, Volume 73, Issue 2, pp. 142 - 149
Journal Article
Toxicology and Applied Pharmacology, ISSN 0041-008X, 11/2012, Volume 264, Issue 3, pp. 413 - 422
Journal Article
PLoS ONE, ISSN 1932-6203, 09/2012, Volume 7, Issue 9, p. e43692
Background: Valproic acid (VPA) is an antiepileptic and anti-migraine prophylactic drug. VPA exhibits two severe side effects, namely acute liver toxicity and... 
CARNITINE | METABOLITES | MECHANISM | RAT | MULTIDISCIPLINARY SCIENCES | ANTICONVULSANT | RETINOL-BINDING-PROTEIN | HISTONE-DEACETYLASE INHIBITORS | RECEPTORS | EXPRESSION | DEHYDROGENASE | Teratogens - toxicity | Embryonic Development - genetics | Vitamin A - toxicity | Histone Deacetylases - metabolism | Hypervitaminosis A - genetics | Hypervitaminosis A - metabolism | Chick Embryo | Valproic Acid - pharmacology | Valproic Acid - toxicity | Hydrogen Peroxide - metabolism | Vitamin A - metabolism | Abnormalities, Drug-Induced | Phenotype | Animals | Proteomics | Homeostasis - drug effects | Kinetics | Retinol-Binding Proteins, Plasma - metabolism | Embryonic Development - drug effects | Retinol-Binding Proteins, Plasma - genetics | Homeostasis - genetics | Superoxide Dismutase - metabolism | Teratogens - metabolism | Hypervitaminosis | Divalproex | Complications and side effects | Development and progression | Dosage and administration | Research | Valproic acid | Risk factors | Cytochrome | Oxidative stress | Histone deacetylase | Biotechnology | Headache | Cytochrome b5 | Dehydrogenases | Toxicity | Liver | Urology | Proteins | Teratogenesis | Vitamin A | NADH | Metabolites | Rodents | Drug dosages | Migraine | Glycerol | Vitamin deficiency | Metabolism | Gene expression | Apolipoproteins | Embryos | Medicine | Side effects | Acids | Carbonic anhydrase | Teratogenicity | Nicotinamide adenine dinucleotide | NADH-cytochrome b5 reductase | Potassium | Retinoic acid | Reductase
Journal Article
Epilepsia, ISSN 0013-9580, 01/2013, Volume 54, Issue 1, pp. 141 - 155
Journal Article
13.