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Journal Article
Biochemical and Biophysical Research Communications, ISSN 0006-291X, 07/2013, Volume 437, Issue 2, pp. 274 - 279
Journal Article
PLoS ONE, ISSN 1932-6203, 12/2016, Volume 11, Issue 12, p. e0167888
Dysfunction of the melanocortin system can result in severe obesity accompanied with dyslipidemia and symptoms of the metabolic syndrome but the effect on... 
BRACHIOCEPHALIC ARTERY | LEPTIN | AORTIC ROOT | MULTIDISCIPLINARY SCIENCES | LIVER | HUMAN OBESITY | NONALCOHOLIC STEATOHEPATITIS | FRAMESHIFT MUTATION | KNOCKOUT MICE | E-DEFICIENT MICE | MOUSE MODELS | Receptor, Melanocortin, Type 4 - deficiency | Receptors, LDL - genetics | Bile Acids and Salts - biosynthesis | Body Size - drug effects | Atherosclerosis - genetics | Mice, Inbred C57BL | RNA, Messenger - genetics | Body Weight - drug effects | Atherosclerosis - complications | Receptor, Melanocortin, Type 4 - genetics | RNA, Messenger - metabolism | Atherosclerosis - metabolism | Non-alcoholic Fatty Liver Disease - complications | Animals | Diet | Receptors, LDL - deficiency | Cholesterol - pharmacology | Hypercholesterolemia - complications | Mice | Hypercholesterolemia - genetics | Mutation | Cholesterol - biosynthesis | Hypercholesterolemia - metabolism | RNA sequencing | Genetically modified mice | Complications and side effects | Obesity | Atherosclerosis | Metabolic diseases | Research | Risk factors | Lipoproteins (low density) | Atherogenesis | Liver | Body weight | Dyslipidemia | Biosynthesis | Gene sequencing | Fatty liver | Rodents | Aorta | Lipoprotein (low density) receptors | Hyperphagia | Cardiovascular system | Melanocortin | Ribonucleic acid--RNA | Cholesterol | Lipoproteins (very low density) | Steatosis | Hypercholesterolemia | Food intake | Arteriosclerosis | Insulin resistance | Receptor density | Metabolic disorders | RNA | Ribonucleic acid | Bile
Journal Article
Journal Article
Journal Article
PLoS ONE, ISSN 1932-6203, 11/2012, Volume 7, Issue 11, p. e48694
Journal Article
FEBS Letters, ISSN 0014-5793, 2004, Volume 566, Issue 1, pp. 173 - 177
The farnesoid X receptor (FXR) is a nuclear receptor activated by bile acids (BAs). In response to ligand‐binding, FXR regulates many genes involved in BA,... 
Farnesoid X receptor | Small interfering RNA | VLDL receptor | Microarray analysis | PFIC, progressive familial intrahepatic cholestasis | IR, inverted repeat | PPAR, peroxisome proliferator-activated receptor | VLDLR, very low density lipoprotein receptor | HDL, high density lipoprotein | NTCP, Na | TG, triglyceride | FA, fatty acid | BA, bile acid | BSEP, bile salt export pump | apo, apolipoprotein | SHP, small heterodimer partner | FXRE, FXR response element | FXR, farnesoid X receptor | CDCA, chenodeoxycholic acid | FGF, fibroblast growth factor | MDR, multidrug resistance gene | LPL, lipoprotein lipase | siRNA, small interfering RNA | TCA, taurocholic acid | I-BABP, intestinal bile acid binding protein | PLTP, phospholipid transfer protein | taurocholate transporting polypeptide | LRH, liver receptor homolog | FXR | microarray analysis | farnesoid X receptor | LDL RECEPTOR | BIOCHEMISTRY & MOLECULAR BIOLOGY | TRANSCRIPTION | small interfering RNA | ACTIVATED RECEPTOR | KNOCKOUT MICE | IDENTIFICATION | ORPHAN NUCLEAR RECEPTOR | CELL BIOLOGY | BIOPHYSICS | METABOLISM | BILE-ACID BIOSYNTHESIS | Transcription, Genetic - drug effects | Bile Acids and Salts - pharmacology | Humans | Transcription Factors - deficiency | Male | Hepatocytes - metabolism | Receptors, Cytoplasmic and Nuclear | DNA-Binding Proteins - deficiency | Transfection | DNA-Binding Proteins - agonists | Time Factors | Chenodeoxycholic Acid - pharmacology | Receptors, LDL - genetics | DNA-Binding Proteins - physiology | Transcription Factors - physiology | Liver - metabolism | Mice, Inbred C57BL | RNA, Small Interfering - pharmacology | Transcription Factors - genetics | DNA-Binding Proteins - genetics | Mice, Knockout | Isoxazoles - pharmacology | Up-Regulation - drug effects | Transcription, Genetic - physiology | Animals | Receptors, LDL - biosynthesis | Cell Line, Tumor | Mice | Transcription Factors - agonists
Journal Article
Prostaglandins, Leukotrienes and Essential Fatty Acids, ISSN 0952-3278, 2009, Volume 82, Issue 2, pp. 141 - 145
Journal Article
Biochemical Journal, ISSN 0264-6021, 04/2012, Volume 443, Issue 1, pp. 65 - 73
The LRP (low-density lipoprotein receptor-related protein) can bind a wide range of structurally diverse ligands to regions composed of clusters of similar to... 
Thermodynamics | Model compound | Complement-like repeat domain (CR domain) | Affinity | Ligand specificity | Low-density lipoprotein receptor | Low-density lipoprotein receptor-related protein (LRP) | Lysine binding | RAP | SITE | low-density lipoprotein receptor | SERINE PROTEASES | RECOGNITION | lysine binding | BIOCHEMISTRY & MOLECULAR BIOLOGY | thermodynamics | HIGH-AFFINITY | PLASMINOGEN-ACTIVATOR INHIBITOR-1 | model compound | low-density lipoprotein receptor-related protein (LRP) | NMR SOLUTION STRUCTURE | ligand specificity | ALPHA-MACROGLOBULIN | complement-like repeat domain (CR domain) | CLUSTER | REPEATS | affinity | Protein Structure, Tertiary | Histidine - analogs & derivatives | Lysine - analogs & derivatives | Humans | Models, Molecular | Recombinant Proteins - chemistry | Spectrometry, Fluorescence | Alanine - chemistry | Arginine - analogs & derivatives | Amino Acid Motifs | Arginine - chemistry | Alanine - analogs & derivatives | Peptide Fragments - chemistry | LDL-Receptor Related Proteins - chemistry | Aspartic Acid - analogs & derivatives | Aspartic Acid - chemistry | Histidine - chemistry | Lysine - chemistry | Binding Sites | Hydrogen-Ion Concentration | uPA, urokinase-type plasminogen activator | LDLR, low-density lipoprotein receptor | TEV, tobacco etch virus | LPL, lipoprotein lipase | RAP, receptor-associated protein | CR, complement-like repeat | PAI-1, plasminogen activator inhibitor-1 | 2-ME, 2-mercaptoethanol | RP-HPLC, reverse-phase HPLC | VLDLR, very-low-density lipoprotein receptor | α2M, α2-macroglobulin | IPTG, isopropyl β-D-thiogalactoside | LRP, low-density lipoprotein receptor-related protein | GST, glutathione transferase
Journal Article