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Vaccine, ISSN 0264-410X, 2011, Volume 29, Issue 41, pp. 7154 - 7162
.... ► Chimeric VLPs and capsomeres displaying antigen from Streptococcus and influenza are evaluated... 
Allergy and Immunology | Virus | Particle | Vaccine | Streptococcus | Manufacture | Influenza | STRUCTURAL PROTEIN | MEDICINE, RESEARCH & EXPERIMENTAL | ESCHERICHIA-COLI | VIRAL PROTEIN | M PROTEIN | IMMUNOLOGY | SMALLPOX ERADICATION | HUMAN-ANTIBODIES | GROUP-A STREPTOCOCCUS | FIELD FLOW FRACTIONATION | CONSERVED REGION | INFLUENZA-VIRUS | Viral Matrix Proteins - genetics | Antigens, Bacterial - immunology | Antibodies, Viral - blood | Antigens, Bacterial - genetics | Streptococcus pyogenes - genetics | Virosomes - metabolism | Biotechnology - methods | Vaccines, Virosome - immunology | Female | Viral Matrix Proteins - metabolism | Antibodies, Bacterial - blood | Genetic Engineering - methods | Recombinant Proteins - metabolism | Gene Expression | Capsid Proteins - metabolism | Streptococcus pyogenes - immunology | Vaccines, Virosome - administration & dosage | Polyomavirus - genetics | Technology, Pharmaceutical - methods | Recombinant Proteins - genetics | Polyomavirus - metabolism | Vaccines, Virosome - genetics | Animals | Escherichia coli - genetics | Virosomes - genetics | Vaccines, Virosome - metabolism | Mice | Viral Matrix Proteins - immunology | Antigens, Bacterial - metabolism | Capsid Proteins - genetics | Antigens | Vaccines | Cell culture | Immunization | Pandemics | Disease | Peptides | Mortality | Viruses | Developing countries--LDCs | E coli | Protein folding | Bacteria | Manufacturing | Antigen presentation | Pathogens | VP1 protein | Structural proteins | Antibodies | Insertion | protein purification | Adjuvants | Intranasal administration | Geographical variations | Self | Virus-like particles | Bioreactors | Drying
Journal Article
Vaccine, ISSN 0264-410X, 2016, Volume 36, Issue 22, pp. 3064 - 3071
Journal Article
Journal Article
Journal of Virology, ISSN 0022-538X, 09/2017, Volume 91, Issue 18
Journal Article
Human Vaccines & Immunotherapeutics, ISSN 2164-5515, 10/2014, Volume 10, Issue 10, pp. 2975 - 2982
.... Thus, alternative cost-effective vaccine production approaches need to be developed. This study uses tobacco plants to express pentameric capsomeres of HPV that have been reported to generate elevated immune responses against HPV... 
plastid transformation | Plant-made vaccines | GST | HPV-16 L1 | capsomeres | cervical cancer | Plastid transformation | Capsomeres | Cervical cancer | glutathione-s-transferase | HUMAN-PAPILLOMAVIRUS TYPE-16 | IMMUNOLOGY | SUSTAINED EFFICACY | HPV | aadA | IMMUNIZATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | L1_2xCysM | polymerase chain reaction | aminoglycoside 3'-adenylyltransferase | modified L1 gene | TRANSFORMATION | virus-like particles | NEUTRALIZING ANTIBODIES | CHALLENGES | VLPs | IMPACT | human papillomavirus | enzyme-linked immunosorbent assay | INVASIVE CERVICAL-CANCER | PCR | ELISA | Recombinant Fusion Proteins - immunology | Humans | Papillomavirus Vaccines - biosynthesis | Human papillomavirus 16 - immunology | Epitopes - immunology | Glutathione Transferase - genetics | Capsid Proteins - immunology | Papillomavirus Infections - immunology | Plastids - genetics | Female | Oncogene Proteins, Viral - genetics | Plastids - metabolism | Recombinant Fusion Proteins - biosynthesis | Plants, Genetically Modified - genetics | Tobacco - metabolism | Oncogene Proteins, Viral - biosynthesis | Glutathione Transferase - biosynthesis | Plants, Genetically Modified - metabolism | Papillomavirus Infections - prevention & control | Tobacco - genetics | Recombinant Fusion Proteins - genetics | Papillomavirus Vaccines - immunology | Oncogene Proteins, Viral - immunology | Human papillomavirus 16 - genetics | Capsid Proteins - biosynthesis | Capsid Proteins - genetics
Journal Article
Biochemical Engineering Journal, ISSN 1369-703X, 09/2014, Volume 90, pp. 255 - 263
Journal Article
Chemical Engineering Science, ISSN 0009-2509, 11/2013, Volume 103, pp. 12 - 20
.... This study describes an approach to synthetically engineer a new influenza vaccine system by antigenic modularization of a carrier viral capsomere, coupled with microbial processing of the sub-unit vaccine... 
Capsomere | M2e | Virus-like particle | Synthetic biology | Vaccine | Influenza | ENDOTOXIN | EXTRACELLULAR DOMAIN | A VACCINE | PHASE-SEPARATION | ENGINEERING, CHEMICAL | IMMUNOGENICITY | RECOMBINANT PROTEINS | IMMUNE-RESPONSES | PAPILLOMAVIRUS | PURIFICATION | Influenza vaccines
Journal Article
Journal Article
Vaccine, ISSN 0264-410X, 2009, Volume 28, Issue 6, pp. 1583 - 1593
.... In this study, we have examined the immunogenicity of capsomeres and virus-like particles (VLPs) from HPV types 2, 27, and 57, the most frequent causative agents of skin warts... 
Allergy and Immunology | Papillomavirus | Prophylactic vaccine | Virus-like particle | Capsomeres | Immunogenicity | Cutaneous | MEDICINE, RESEARCH & EXPERIMENTAL | NEUTRALIZING ANTIBODIES | HUMAN-PAPILLOMAVIRUS TYPE-16 | EPIDERMODYSPLASIA-VERRUCIFORMIS | MAJOR CAPSID PROTEIN | RANDOMIZED CONTROLLED-TRIAL | TRANSPLANT RECIPIENTS | IMMUNOLOGY | SUSTAINED EFFICACY | CYTOTOXIC T-LYMPHOCYTES | L1 CAPSOMERES | MONOCLONAL-ANTIBODIES | Vaccines, Virosome | Adjuvants, Immunologic - administration & dosage | Interferon-gamma - secretion | Mice, Inbred C57BL | Warts - immunology | Alphapapillomavirus - immunology | Virosomes - immunology | Antibodies, Viral - blood | Skin Diseases, Viral - immunology | Cross Reactions | Capsid - immunology | Animals | Skin Diseases, Viral - prevention & control | Warts - prevention & control | Capsid Proteins - immunology | Papillomavirus Vaccines - immunology | T-Lymphocytes - immunology | Mice | Oncogene Proteins, Viral - immunology | Antibodies, Neutralizing - blood | Antigens | Dermatology | Oncology, Experimental | Vaccination | Organ transplant recipients | Dermatologic agents | Vaccines | Research | T cells | Warts | Analysis | Formulae, receipts, prescriptions | Transplantation of organs, tissues, etc | Papillomavirus infections | Cancer | Proteins | Human papillomavirus | Bacteria | Infections | Cervical cancer | Skin cancer | Index Medicus
Journal Article
Transgenic Research, ISSN 0962-8819, 4/2011, Volume 20, Issue 2, pp. 271 - 282
.... Capsomeres have recently been demonstrated to be highly immunogenic and to have a number of advantages as a potential cost-effective alternative to VLP-based HPV vaccines... 
Human Genetics | Biomedicine | HPV-16 | L1_2xCysM gene | Male sterility | Molecular Medicine | Capsomeres | Plant Sciences | Plastids | Plant Genetics & Genomics | Animal Genetics and Genomics | ELISA | TRANSFORMATION | NEUTRALIZING ANTIBODIES | CHLOROPLAST GENOME | L1_ 2xCysM gene | BIOCHEMISTRY & MOLECULAR BIOLOGY | ESCHERICHIA-COLI | BIOCHEMICAL RESEARCH METHODS | MAJOR CAPSID PROTEIN | TYPE-16 | BIOPHARMACEUTICALS | IMMUNIZATION | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | VIRUS-LIKE PARTICLES | CYTOPLASMIC MALE-STERILITY | Papillomavirus Vaccines - genetics | Humans | Vaccines, Virus-Like Particle - metabolism | Vaccines, Virus-Like Particle - genetics | Tobacco - virology | Capsid Proteins - immunology | Female | Oncogene Proteins, Viral - genetics | Capsid - metabolism | Transgenes | Oncogene Proteins, Viral - metabolism | Papillomavirus Vaccines - economics | Plants, Genetically Modified - genetics | Capsid Proteins - metabolism | Tobacco - metabolism | Plants, Genetically Modified - immunology | Chloroplasts - virology | Virion - metabolism | Virus Assembly | Chloroplasts - metabolism | Human papillomavirus 16 - metabolism | Capsid - immunology | Papillomavirus Infections - prevention & control | Tobacco - genetics | Papillomavirus Vaccines - immunology | Vaccines, Virus-Like Particle - immunology | Mutation | Human papillomavirus 16 - genetics | Capsid Proteins - biosynthesis | Capsid Proteins - genetics | Tobacco industry | Analysis | Developing countries | Monoclonal antibodies | Vaccines | Papillomavirus infections | Recombinant proteins | Enzyme-linked immunosorbent assay | Antigenic determinants | double prime L1 protein | Sucrose | Centrifugation | Epitopes | Sedimentation | Virus-like particles | Tobacco | Chloroplasts | Immunogenicity | Density gradients | cesium chloride | Cervical carcinoma | Cervical cancer
Journal Article