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Virology, ISSN 0042-6822, 10/2018, Volume 523, pp. 121 - 128
The HIV-1 accessory protein Vpr displays various activities that can favor viral replication such as G cell cycle arrest. Vpr also modulates host gene... 
HIV-1 | CD62L | Vpr | DDR | Nef | ATR | TRANSCRIPTION FACTORS | PROTEIN VPR | ACTIVATION | DNA-DAMAGE RESPONSE | NKG2D RECEPTOR | HUMAN-IMMUNODEFICIENCY-VIRUS | CLASS-I HDACS | VIROLOGY | LIGANDS | TYPE-1 | T-CELLS | Ataxia Telangiectasia Mutated Proteins - metabolism | Humans | L-Selectin - genetics | vif Gene Products, Human Immunodeficiency Virus - genetics | RNA, Messenger - metabolism | L-Selectin - metabolism | vif Gene Products, Human Immunodeficiency Virus - metabolism | nef Gene Products, Human Immunodeficiency Virus - metabolism | CD4-Positive T-Lymphocytes - virology | vpr Gene Products, Human Immunodeficiency Virus - metabolism | HIV-1 - metabolism | Signal Transduction | Jurkat Cells | RNA, Messenger - genetics | Viral Regulatory and Accessory Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Gene Expression Regulation | HIV-1 - genetics | Viral Regulatory and Accessory Proteins - metabolism | Host-Pathogen Interactions | Human Immunodeficiency Virus Proteins - metabolism | G2 Phase Cell Cycle Checkpoints - genetics | Histones - genetics | nef Gene Products, Human Immunodeficiency Virus - genetics | Human Immunodeficiency Virus Proteins - genetics | Histones - metabolism | Primary Cell Culture | Ataxia Telangiectasia Mutated Proteins - genetics | vpr Gene Products, Human Immunodeficiency Virus - genetics | RNA | T cells | HIV (Viruses) | Gene expression | Analysis
Journal Article
Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, 6/2011, Volume 108, Issue 24, pp. 9975 - 9980
During the early stages of HIV-1 replication the conical capsid composed of p24 CA protein dissociates from the rest of the cytoplasmic viral complex by a... 
Half lives | HIV | Memory interference | Virions | Reverse transcription | Viruses | Infections | Kinetics | Capsid | HIV 1 | Early events | Retrovirus | CAPSID PROTEIN | CELLS | retrovirus | PREINTEGRATION COMPLEX | MULTIDISCIPLINARY SCIENCES | HOST RESTRICTION | HUMAN-IMMUNODEFICIENCY-VIRUS | INHIBITION | early events | RESISTANCE | INFECTION | ASSOCIATION | TYPE-1 CORE | Anti-HIV Agents - pharmacology | Cyclosporine - pharmacology | Virus Replication - genetics | Humans | Virion - genetics | Green Fluorescent Proteins - genetics | Recombinant Fusion Proteins - metabolism | Reverse Transcription | HIV Core Protein p24 - genetics | Time Factors | HEK293 Cells | Macrolides - pharmacology | vpr Gene Products, Human Immunodeficiency Virus - metabolism | Cell Line | Green Fluorescent Proteins - metabolism | HIV-1 - metabolism | Virus Replication - drug effects | HIV-1 - genetics | Virion - metabolism | Human Immunodeficiency Virus Proteins - metabolism | Nevirapine - pharmacology | Animals | HIV Core Protein p24 - metabolism | Recombinant Fusion Proteins - genetics | Human Immunodeficiency Virus Proteins - genetics | Luminescent Proteins - genetics | HeLa Cells | Microscopy, Fluorescence | vpr Gene Products, Human Immunodeficiency Virus - genetics | Luminescent Proteins - metabolism | Genetic aspects | Research | Genetic transcription | HIV (Viruses) | Health aspects | Biological Sciences
Journal Article
Journal of General Virology, ISSN 0022-1317, 04/2016, Volume 97, Issue 4, pp. 813 - 824
Human immunodeficiency virus (HIV) is the causative agent of the deadly disease AIDS, which is characterized by the progressive decline of CD4 T+-cells.... 
LYMPHOCYTE APOPTOSIS | VIROLOGY | INDEPENDENT MECHANISMS | CELLULAR RESERVOIRS | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | CD4(+) T-CELLS | HIV-1-INFECTED PATIENTS | ANTIRETROVIRAL THERAPY | NF-KAPPA-B | CHRONIC HIV-INFECTION | POTENTIAL MECHANISM | CANCER-THERAPY | HIV Envelope Protein gp120 - genetics | Human Immunodeficiency Virus Proteins - immunology | Humans | HIV Protease - genetics | Apoptosis - genetics | CD4-Positive T-Lymphocytes - pathology | HIV Envelope Protein gp120 - immunology | HIV Infections - immunology | HIV Infections - pathology | Apoptosis Regulatory Proteins - genetics | HIV Protease - immunology | tat Gene Products, Human Immunodeficiency Virus - immunology | CD4-Positive T-Lymphocytes - virology | Apoptosis Regulatory Proteins - immunology | Signal Transduction | Gene Expression Regulation - immunology | Viral Regulatory and Accessory Proteins - immunology | tat Gene Products, Human Immunodeficiency Virus - genetics | HIV Infections - virology | Viral Regulatory and Accessory Proteins - genetics | vpr Gene Products, Human Immunodeficiency Virus - immunology | HIV-1 - genetics | Host-Pathogen Interactions | HIV-1 - immunology | Apoptosis - immunology | nef Gene Products, Human Immunodeficiency Virus - genetics | nef Gene Products, Human Immunodeficiency Virus - immunology | Human Immunodeficiency Virus Proteins - genetics | Virus Latency - immunology | vpr Gene Products, Human Immunodeficiency Virus - genetics
Journal Article
PLoS pathogens, ISSN 1553-7366, 07/2007, Volume 3, Issue 7, pp. e94 - 0927
Despite the formidable mutational capacity and sequence diversity of HIV-1, evidence suggests that viral evolution in response to specific selective pressures... 
T-LYMPHOCYTE ESCAPE | CELL RESPONSES | VARIANTS | IMMUNE PRESSURE | PEPTIDE MOTIFS | MICROBIOLOGY | HUMAN-IMMUNODEFICIENCY-VIRUS | SELECTION | TYPE-1 INFECTION | PARASITOLOGY | DISEASE PROGRESSION | PRIMARY INFECTION | Minor Histocompatibility Antigens | Humans | Molecular Sequence Data | Epitopes, T-Lymphocyte - genetics | Phylogeny | CD4-Positive T-Lymphocytes - immunology | nef Gene Products, Human Immunodeficiency Virus - metabolism | Epitopes, T-Lymphocyte - immunology | vpr Gene Products, Human Immunodeficiency Virus - metabolism | Amino Acid Sequence | Viral Regulatory and Accessory Proteins - genetics | CD4-Positive T-Lymphocytes - metabolism | Genes, MHC Class I - physiology | Selection, Genetic | CD4 Lymphocyte Count | Histocompatibility Antigens Class I - genetics | HIV-1 - genetics | Viral Regulatory and Accessory Proteins - metabolism | Polymorphism, Genetic | Human Immunodeficiency Virus Proteins - metabolism | HIV-1 - immunology | nef Gene Products, Human Immunodeficiency Virus - genetics | Gene Expression Regulation, Viral | Human Immunodeficiency Virus Proteins - genetics | Mutation | vpr Gene Products, Human Immunodeficiency Virus - genetics | Evolution, Molecular | Evolution | Genetic aspects | Research | HIV (Viruses) | Viral genetics | Viruses | Immunology | Virology | Studies | Medical research | Genes
Journal Article
PLoS ONE, ISSN 1932-6203, 07/2013, Volume 8, Issue 7, p. e68108
The precursor group-specific antigen (wpr55(Gag)) is central to HIV-1 assembly. Its expression alone is sufficient to assemble into virus-like particles. It... 
5-UNTRANSLATED REGION | HOST PROTEIN-SYNTHESIS | EFFICIENT CLEAVAGE | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | POLY(A)-BINDING PROTEIN | MEDIATED TRANSLATION | EUKARYOTIC TRANSLATION | RIBOSOME ENTRY SITE | GENOMIC RNA | CAP-INDEPENDENT TRANSLATION | Cell Line | Genome, Viral | HIV-1 - metabolism | gag Gene Products, Human Immunodeficiency Virus - biosynthesis | tat Gene Products, Human Immunodeficiency Virus - genetics | Humans | RNA, Messenger - genetics | Regulatory Sequences, Ribonucleic Acid | Peptide Chain Initiation, Translational | HIV-1 - genetics | RNA, Messenger - metabolism | Genetic Vectors - genetics | RNA, Viral - genetics | Gene Expression Regulation, Viral | RNA, Viral - metabolism | vpr Gene Products, Human Immunodeficiency Virus - metabolism | Gene Order | vpr Gene Products, Human Immunodeficiency Virus - genetics | tat Gene Products, Human Immunodeficiency Virus - metabolism | Proteins | Messenger RNA | HIV (Viruses) | Proteases | Genetic translation | Health aspects | Transcription | Laboratories | Foot & mouth disease | Replication initiation | Viruses | Infections | Biology | mRNA | Virus-like particles | Vpr protein | Synthesis | Gag protein | Human immunodeficiency virus--HIV | Assembly | Internal ribosome entry site | Translation | Translation initiation | Gene expression | Virology | Medicine | Studies | Tat protein | Encapsidation | Ribonucleic acids | Protein synthesis | Initiation factor eIF-4G | Binding sites | Viral infections | HIV | Human immunodeficiency virus
Journal Article
Journal of Biological Chemistry, ISSN 0021-9258, 12/2014, Volume 289, Issue 51, pp. 35102 - 35110
Journal Article
PLoS ONE, ISSN 1932-6203, 08/2014, Volume 9, Issue 8, p. e106418
Macrophages act as reservoirs of human immunodeficiency virus type 1 (HIV-1) and play an important role in its transmission to other cells. HIV-1 Vpr is a... 
NUCLEAR IMPORT | UBIQUITIN LIGASE | I INTERFERONS | MULTIDISCIPLINARY SCIENCES | IMMUNODEFICIENCY-VIRUS TYPE-1 | CELL-CYCLE ARREST | TERMINALLY TRUNCATED FORM | T-CELLS | VIRAL-PROTEIN-R | PRE-MESSENGER-RNA | HIV-1-INFECTED MACROPHAGES | Dependovirus - genetics | Phosphorylation | Interferons - pharmacology | Oligonucleotide Array Sequence Analysis - methods | Humans | Cells, Cultured | Gene Expression Profiling - methods | Interferon Regulatory Factor-7 - genetics | Immunity, Innate | STAT1 Transcription Factor - genetics | Interferon Regulatory Factor-7 - metabolism | Gene Expression Regulation - drug effects | Dependovirus - physiology | Macrophages - metabolism | STAT1 Transcription Factor - metabolism | Macrophages - virology | HEK293 Cells | Macrophages - drug effects | HeLa Cells | vpr Gene Products, Human Immunodeficiency Virus - metabolism | vpr Gene Products, Human Immunodeficiency Virus - genetics | Infection | Adenoviruses | Genes | Cellular signal transduction | Interferon | HIV (Viruses) | Macrophages | Biological response modifiers | Health aspects | Flow cytometry | Transcription | Pathogenesis | Viruses | Infections | Proteins | Vpr protein | Acquired immune deficiency syndrome--AIDS | Human immunodeficiency virus--HIV | Cell cycle | Post-translation | Stat1 protein | Deoxyribonucleic acid--DNA | Recombinant | Immune system | Tyrosine | Antigens | Cytomegalovirus | Immune response | Myxovirus resistance proteins | Dendritic cells | Gene expression | Disease prevention | Interferon regulatory factor 7 | Monocytes | Infectious diseases | Disease transmission | DNA microarrays | Transduction | TRAIL protein | Apoptosis | Acquired immune deficiency syndrome | Deoxyribonucleic acid | AIDS | HIV | DNA | Human immunodeficiency virus
Journal Article
Journal of Virology, ISSN 0022-538X, 2015, Volume 89, Issue 20, pp. 10656 - 10667
Expression of the cytoprotective enzyme heme oxygenase-1 (HO-1) is significantly reduced in the brain prefrontal cortex of HIV-positive individuals with... 
C VIRUS-REPLICATION | OXIDATIVE STRESS | IN-VITRO | VIROLOGY | GENE | LUNG INJURY | NEUROCOGNITIVE DISORDERS | CORE PROTEIN | EXPRESSION | MICROSATELLITE POLYMORPHISM | TRANSGENIC MICE | Anti-HIV Agents - pharmacology | Glutamic Acid - biosynthesis | HIV-1 - pathogenicity | Human Immunodeficiency Virus Proteins - immunology | Humans | Anemia, Hemolytic - genetics | Heme Oxygenase-1 - deficiency | Neuroglia - drug effects | Iron Metabolism Disorders - virology | Heme Oxygenase-1 - genetics | Macrophages - virology | HIV-2 - pathogenicity | Neuroglia - immunology | Anemia, Hemolytic - virology | Iron Metabolism Disorders - immunology | Macrophages - immunology | Virus Replication - drug effects | Gene Expression | Anemia, Hemolytic - immunology | Viral Regulatory and Accessory Proteins - immunology | Growth Disorders - immunology | Viral Regulatory and Accessory Proteins - genetics | vpr Gene Products, Human Immunodeficiency Virus - immunology | Growth Disorders - virology | Rats | Rats, Sprague-Dawley | Drug Resistance, Viral - genetics | HIV-1 - immunology | Phenotype | Animals | Iron Metabolism Disorders - genetics | nef Gene Products, Human Immunodeficiency Virus - genetics | Drug Resistance, Viral - immunology | nef Gene Products, Human Immunodeficiency Virus - immunology | HIV-2 - immunology | Heme Oxygenase-1 - immunology | Human Immunodeficiency Virus Proteins - genetics | Macrophages - drug effects | Neuroglia - virology | Primary Cell Culture | Glutamic Acid - toxicity | Growth Disorders - genetics | Macrophage Activation - drug effects | vpr Gene Products, Human Immunodeficiency Virus - genetics | Index Medicus
Journal Article
Cell Host & Microbe, ISSN 1931-3128, 12/2014, Volume 16, Issue 6, pp. 722 - 735
The HIV-1 accessory protein Vpr enhances infection of primary macrophages through unknown mechanisms. Recent studies demonstrated that Vpr interactions with... 
UBIQUITIN LIGASE | MICROBIOLOGY | TYPE-1 VPR | HUMAN-IMMUNODEFICIENCY-VIRUS | MOLECULAR CLONE | T-CELL CLONE | REPLICATION | INHIBITION | VIROLOGY | ACCESSORY PROTEINS | INFECTION | PARASITOLOGY | CYCLE | Ubiquitin | Biological response modifiers | HIV (Viruses) | Macrophages | Ligases
Journal Article
Journal Article
JAIDS Journal of Acquired Immune Deficiency Syndromes, ISSN 1525-4135, 05/2016, Volume 72, Issue 1, pp. 31 - 38
BACKGROUND:The genomic heterogeneity of HIV-1 impedes the ability of consensus sequences in vaccines to elicit effective antiviral immune responses. AGS-004... 
Autologous antigen | Dendritic cell therapy | Functional cure | HIV | Therapeutic immunization |