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Nature Cell Biology, ISSN 1465-7392, 2015, Volume 17, Issue 8, pp. 1074 - 1087
Defects in primary cilium biogenesis underlie the ciliopathies, a growing group of genetic disorders. We describe a whole-genome siRNA-based reverse genetics... 
JOUBERT-SYNDROME | RPGRIP1 | TRANSPORT | CENTRIOLE BIOGENESIS | PROTEIN | C-ELEGANS | MUTATIONS | PHOTORECEPTOR CELLS | MASTER REGULATOR | PRIMARY CILIA | CELL BIOLOGY | Humans | Pregnancy Proteins - genetics | Databases, Genetic | Suppressor Factors, Immunologic - genetics | Photoreceptor Cells - ultrastructure | Pregnancy Proteins - metabolism | Ellis-Van Creveld Syndrome - genetics | Cerebellum - abnormalities | Genetic Testing - methods | Suppressor Factors, Immunologic - metabolism | Membrane Proteins - deficiency | Transfection | RNA Interference | HEK293 Cells | Kidney Diseases, Cystic - genetics | Genomics - methods | Genetic Predisposition to Disease | Genome-Wide Association Study | Reproducibility of Results | Caenorhabditis elegans - metabolism | Cilia - pathology | Caenorhabditis elegans - genetics | Membrane Proteins - genetics | Mice, Inbred C57BL | Abnormalities, Multiple | Genetic Markers | Eye Abnormalities - genetics | Cilia - metabolism | Zebrafish - genetics | Cilia - genetics | Mice, Knockout | Proteins - genetics | Caenorhabditis elegans - ultrastructure | Phenotype | Animals | Cerebellar Diseases - genetics | Ciliary Motility Disorders - pathology | Proteins - metabolism | Photoreceptor Cells - metabolism | Zebrafish - metabolism | Retina - abnormalities | High-Throughput Nucleotide Sequencing | Ciliary Motility Disorders - metabolism | Mutation | Ciliary Motility Disorders - genetics | RNA | Cilia and ciliary motion | Genetic research | Biosynthesis | Genetic aspects | Research | Gene expression | Properties | reverse genetics | cilia | ciliopathies | Joubert syndrome | whole-genome siRNA screen | Jeune syndrome
Journal Article
Molecular and cellular biology, ISSN 0270-7306, 01/2019, Volume 39, Issue 1
The proteasome is the proteolytic machinery at the center of regulated intracellular protein degradation and participates in various cellular processes.... 
knock-in mice | proteasome | protein turnover | molecular aging | whole-genome siRNA screen | LOCALIZATION | PHOSPHORYLATION | BIOCHEMISTRY & MOLECULAR BIOLOGY | RECEPTOR | 26S PROTEASOME | CELL BIOLOGY | YEAST | UBIQUITINATED PROTEINS | LIPODYSTROPHY | DEGRADATION | CONTRIBUTES | SUBUNIT
Journal Article
05/2014, ISBN 9781118444160, 15
In this chapter, the authors discuss the insights they have gained into the molecular regulation of the canonical Wnt signaling pathway from global RNAi... 
short interfering RNAs (siRNAs) | RNAi‐based whole‐genome screens | Wnt/Wg signaling pathway | cancer genome | Wnt/β‐catenin pathway mechanisms | Short interfering RNAs (siRNAs) | Cancer genome | Wnt/β-catenin pathway mechanisms | RNAi-based whole-genome screens
Book Chapter
Clinical Infectious Diseases, ISSN 1058-4838, 4/2010, Volume 50, Issue 7, pp. 1022 - 1032
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 1849 - 14
Journal Article
The Journal of Infectious Diseases, ISSN 0022-1899, 11/2017, Volume 216, Issue 9, pp. 1063 - 1069
Journal Article
BMC Genomics, ISSN 1471-2164, 09/2016, Volume 17, Issue 1
Background: Genome-wide CRISPR-Cas9 dropout screens can identify genes whose knockout affects cell viability. Recent CRISPR screens detected thousands of... 
NRAS | Driver mutations | Kinase | Negative selection | EGFR | Whole genome CRISPR screen | Dropout | CELLS | DISCOVERY | BIOTECHNOLOGY & APPLIED MICROBIOLOGY | GROWTH | GENES | GENETICS & HEREDITY | Genome-wide association studies | Usage | Research | Gene mutations | Cancer cells
Journal Article
Nature Communications, ISSN 2041-1723, 12/2018, Volume 9, Issue 1, pp. 3664 - 9
Journal Article