X
Search Filters
Format Format
Subjects Subjects
Subjects Subjects
X
Sort by Item Count (A-Z)
Filter by Count
xanomeline (180) 180
pharmacology & pharmacy (83) 83
animals (74) 74
neurosciences (67) 67
schizophrenia (67) 67
alzheimers-disease (66) 66
chemistry, medicinal (51) 51
humans (51) 51
index medicus (49) 49
alzheimer's disease (46) 46
agonist (43) 43
male (39) 39
muscarinic agonists - pharmacology (38) 38
psychiatry (38) 38
rats (33) 33
muscarinic receptors (31) 31
thiadiazoles - pharmacology (30) 30
activation (29) 29
pyridines - pharmacology (29) 29
agonist xanomeline (28) 28
mice (28) 28
acetylcholine (27) 27
biochemistry & molecular biology (25) 25
acetylcholine-receptor (24) 24
behavioral symptoms (24) 24
muscarinic (23) 23
dose-response relationship, drug (22) 22
knockout mice (22) 22
chemistry, organic (21) 21
cho cells (21) 21
antipsychotic-like activity (20) 20
binding (20) 20
brain (20) 20
discovery (20) 20
positive allosteric modulator (20) 20
prefrontal cortex (20) 20
cricetinae (19) 19
clinical neurology (18) 18
n-desmethylclozapine (17) 17
receptor, muscarinic m1 - metabolism (17) 17
receptors, muscarinic - drug effects (17) 17
acetylcholine-receptors (16) 16
muscarinic acetylcholine-receptor (16) 16
muscarinic agonists - therapeutic use (16) 16
antipsychotic agents - pharmacology (15) 15
cognition (15) 15
in-vivo (15) 15
memory (15) 15
rats, sprague-dawley (15) 15
receptor, muscarinic m1 - agonists (15) 15
alzheimer disease - drug therapy (14) 14
female (14) 14
m-1 (14) 14
muscarinic receptor agonist (14) 14
pharmacology (14) 14
identification (13) 13
receptors, muscarinic - metabolism (13) 13
receptors, muscarinic - physiology (13) 13
schizophrenia - drug therapy (13) 13
cricetulus (12) 12
muscarinic acetylcholine receptor (12) 12
muscarinic antagonists - pharmacology (12) 12
protein-coupled receptors (12) 12
agonists (11) 11
allosteric regulation (11) 11
antipsychotic (11) 11
clozapine (11) 11
dopamine (11) 11
expression (11) 11
hippocampus (11) 11
ligands (11) 11
muscarinic receptor (11) 11
neurons (11) 11
subtypes (11) 11
thiadiazoles - therapeutic use (11) 11
allosteric modulation (10) 10
amyloid precursor protein (10) 10
article (10) 10
donepezil (10) 10
muscarinic acetylcholine-receptors (10) 10
muscarinic agonist (10) 10
pyridines - therapeutic use (10) 10
allosteric modulators (9) 9
antagonist (9) 9
antipsychotic agents - therapeutic use (9) 9
carbachol - pharmacology (9) 9
dementia (9) 9
functional selectivity (9) 9
prepulse inhibition (9) 9
pyridines - chemistry (9) 9
biomedicine (8) 8
brain - metabolism (8) 8
cognition - drug effects (8) 8
disease (8) 8
efficacy (8) 8
hippocampus - drug effects (8) 8
localization (8) 8
muscarinic acetylcholine receptors (8) 8
rat-brain (8) 8
receptor agonist xanomeline (8) 8
more...
Language Language
Publication Date Publication Date
Click on a bar to filter by decade
Slide to change publication date range


JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 11/2009, Volume 29, Issue 45, pp. 14271 - 14286
M-1 muscarinic acetylcholine receptors (mAChRs) may represent a viable target for treatment of disorders involving impaired cognitive function. However, a... 
ACTIVATION | MEMORY | CORTEX | XANOMELINE | AMYLOID PRECURSOR PROTEIN | NEUROSCIENCES | MODULATION | DISCOVERY | AGONIST | BETA
Journal Article
Neuropharmacology, ISSN 0028-3908, 05/2018, Volume 133, pp. 129 - 144
Xanomeline (3-(Hexyloxy)-4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazole) is a muscarinic agonist that is considered to be functionally selective... 
Molecular dynamics | Xanomeline | Receptor activation | Membrane cholesterol | Muscarinic acetylcholine receptors | ACTIVATION | PROTEIN | ALZHEIMERS-DISEASE | SCHIZOPHRENIA | AGONIST XANOMELINE | ALLOSTERIC MODULATION | NEUROSCIENCES | ACETYLCHOLINE-RECEPTOR | ORGANIZATION | STRUCTURAL BASIS | PHARMACOLOGY & PHARMACY | BINDING
Journal Article
NEURON, ISSN 0896-6273, 09/2016, Volume 91, Issue 6, pp. 1244 - 1252
Muscarinic receptors represent a promising therapeutic target for schizophrenia, but the mechanisms underlying the antipsychotic efficacy of muscarinic... 
KNOCK-OUT MICE | TRANSMISSION | ACTIVATION | MUSCARINIC ACETYLCHOLINE | CHOLINERGIC INTERNEURONS | NEURONS | SCHIZOPHRENIA | AGONIST XANOMELINE | EXPRESSION | NEUROSCIENCES | MOLECULAR-MECHANISMS
Journal Article
Neuroscience, ISSN 0306-4522, 08/2019, Volume 414, pp. 60 - 76
Activation of the M muscarinic acetylcholine receptor (M R) may be an effective therapeutic approach for Alzheimer's disease (AD), dementia with Lewy bodies,... 
donepezil | c-Fos | M1 muscarinic acetylcholine receptor | xanomeline | TAK-071
Journal Article
ORGANIC PROCESS RESEARCH & DEVELOPMENT, ISSN 1083-6160, 10/2017, Volume 21, Issue 10, pp. 1610 - 1615
A practical and chromatography-free synthetic process to selective M-1 and M-4 muscarinic acetylcholine receptors agonist was developed and demonstrated on a... 
MIGRATION | POTENT | CARBAMOYL | CHEMISTRY, ORGANIC | XANOMELINE | CHEMISTRY, APPLIED | DERIVATIVES | DISCOVERY
Journal Article
JOURNAL OF MEDICINAL CHEMISTRY, ISSN 0022-2623, 01/2016, Volume 59, Issue 1, pp. 388 - 409
Positive allosteric modulators (PAMs) of the M1 muscarinic acetylcholine receptor (M1 mAChR) are a promising strategy for the treatment of the cognitive... 
CHEMISTRY, MEDICINAL | MODELS | ALZHEIMERS-DISEASE | SCHIZOPHRENIA | XANOMELINE | MICE | INHIBITORS | PATHOLOGY | IDENTIFICATION | AGONIST
Journal Article
DRUG DISCOVERY TODAY, ISSN 1359-6446, 12/2013, Volume 18, Issue 23-24, pp. 1185 - 1199
Allosteric modulation of AMPA, NR2B, mG1u(2), mG1u(5) and M-1, targeting glutamatergic dysfunction, represents a significant area of research for the treatment... 
ANTIPSYCHOTIC-LIKE ACTIVITY | IN-VITRO | NEUROCOGNITIVE DEFICITS | HYPOFUNCTION | CNS PENETRANT | PAM ML137 | PHARMACOLOGY & PHARMACY | CONTINUED OPTIMIZATION | AGONIST XANOMELINE | SELECTIVE ACTIVATION | DISCOVERY
Journal Article
PLOS ONE, ISSN 1932-6203, 03/2019, Volume 14, Issue 3
Activation of the muscarinic M-1 receptor is a promising approach to improve cognitive deficits associated with cholinergic dysfunction in Alzheimer's disease,... 
DONEPEZIL | DIAGNOSTIC-VALUE | DEMENTIA | MEMORY | ALZHEIMERS-DISEASE | EEG | MULTIDISCIPLINARY SCIENCES | XANOMELINE | ACETYLCHOLINE-RECEPTOR | BRAIN | COGNITIVE DEFICITS
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 01/2016, Volume 41, Issue 2, pp. 598 - 610
Schizophrenia patients exhibit deficits in signaling of the M1 subtype of muscarinic acetylcholine receptor (mAChR) in the prefrontal cortex (PFC) and also... 
DEPRESSION | ACTIVATION | PSYCHIATRY | RATS | AGONIST XANOMELINE | NEUROSCIENCES | PHENCYCLIDINE | GLUTAMATE RECEPTORS | SOCIAL-INTERACTION | MEDIAL PREFRONTAL CORTEX | ANIMAL-MODELS | PHARMACOLOGY & PHARMACY | DYSFUNCTION
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 07/2018, Volume 43, Issue 8, pp. 1763 - 1771
Highly selective positive allosteric modulators (PAMs) of the M-1 subtype of muscarinic acetylcholine receptor have emerged as an exciting new approach for... 
EFFICACY | PSYCHIATRY | SCHIZOPHRENIA | XANOMELINE | SELECTIVE ACTIVATION | NEUROSCIENCES | PREFRONTAL CORTEX | DISCOVERY | MUSCARINIC ACETYLCHOLINE-RECEPTOR | MEMORY | NEURONS | PHARMACOLOGY & PHARMACY | SUBTYPE 5
Journal Article
Journal of Pharmacology and Experimental Therapeutics, ISSN 0022-3565, 02/2016, Volume 356, Issue 2, pp. 293 - 304
The muscarinic acetylcholine receptor subtype 1 (M-1) receptors play an important role in cognition and memory, and are considered to be attractive targets for... 
ACETYLCHOLINE-RECEPTORS | ALZHEIMERS-DISEASE | POSITIVE ALLOSTERIC MODULATORS | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY | CENTRAL-NERVOUS-SYSTEM | XANOMELINE | COGNITION | AGONISTS | SUBTYPE 5 | DISCOVERY
Journal Article
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, ISSN 0027-8424, 08/2008, Volume 105, Issue 31, pp. 10978 - 10983
Current antipsychotics provide symptomatic relief for patients suffering from schizophrenia and related psychoses; however, their effectiveness is variable and... 
cooperativity | MULTIDISCIPLINARY SCIENCES | PROTEIN-COUPLED RECEPTORS | XANOMELINE | POSITIVE COOPERATIVITY | COGNITIVE FUNCTION | ACETYLCHOLINE-RECEPTORS | SUBTYPE SELECTIVITY | MEMORY | PHARMACOLOGY | cholinergic | GPCR | CENTRAL-NERVOUS-SYSTEM | AGONIST
Journal Article
Neuropsychopharmacology, ISSN 0893-133X, 2018, Volume 44, Issue 5, pp. 950 - 960
The muscarinic M-1 receptor (M1R) is a promising target for treating cognitive impairment associated with cholinergic deficits in disorders such as Alzheimer's... 
DEMENTIA | PSYCHIATRY | ALZHEIMERS-DISEASE | XANOMELINE | NEUROSCIENCES | MUSCARINIC ACETYLCHOLINE-RECEPTORS | PREFRONTAL CORTEX | DONEPEZIL | HIPPOCAMPUS | PHARMACOLOGY & PHARMACY | OSCILLATIONS | NEUROPSYCHOLOGICAL TEST-PERFORMANCE | AGONIST
Journal Article
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, ISSN 0022-3565, 12/2008, Volume 327, Issue 3, pp. 941 - 953
Previous clinical and animal studies suggest that selective activators of M-1 and/or M-4 muscarinic acetylcholine receptors (mAChRs) have potential as novel... 
SUBTYPE-5 | MODULATORS | IN-VIVO | HYPOTHESIS | STRIATAL CHOLINERGIC INTERNEURONS | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY | METABOTROPIC GLUTAMATE RECEPTORS | AGONIST XANOMELINE | KNOCKOUT MICE | ANTIPSYCHOTIC-LIKE
Journal Article
JOURNAL OF NEUROSCIENCE, ISSN 0270-6474, 10/2008, Volume 28, Issue 41, pp. 10422 - 10433
Recent studies suggest that subtype-selective activators of M-1/M-4 muscarinic acetylcholine receptors (mAChRs) may offer a novel approach for the treatment of... 
CLOZAPINE | HALOPERIDOL | muscarinic acetylcholine receptors | ALZHEIMERS-DISEASE | TBPB | mAChR | BEHAVIORAL SYMPTOMS | AGONIST XANOMELINE | schizophrenia | IDENTIFICATION | NEUROSCIENCES | M-1 allosteric agonist | EARLY GENE-EXPRESSION | N-DESMETHYLCLOZAPINE | IN-VIVO | MICE | Alzheimer's disease
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 10/2016, Volume 90, Issue 4, pp. 427 - 436
Recently, the first subtype-selective allosteric modulators of the M-5 muscarinic acetylcholine receptor (mAChR) have been described, but their molecular... 
ACTIVATION | PROTEIN-COUPLED RECEPTOR | DRUG DEVELOPMENT | PHARMACOLOGY & PHARMACY | MICE | XANOMELINE | RAT-BRAIN | LIGAND | POTENTIATOR | INSIGHTS | AGONIST
Journal Article
NEUROPSYCHOPHARMACOLOGY, ISSN 0893-133X, 06/2014, Volume 39, Issue 7, pp. 1578 - 1593
Accumulating evidence suggests that selective M-4 muscarinic acetylcholine receptor (mAChR) activators may offer a novel strategy for the treatment of... 
allosteric | PREPULSE INHIBITION | PSYCHIATRY | FUNCTIONAL CONNECTIVITY | AGONIST XANOMELINE | OREXIN NEURONS | KNOCKOUT MICE | NEUROSCIENCES | PREFRONTAL CORTEX | muscarinic | PHARMACOLOGICAL MRI | IN-VIVO VALIDATION | M-4 | phMRI | CHOLINERGIC INTERNEURONS | VU0152100 | DOPAMINE | PHARMACOLOGY & PHARMACY | antipsychotic
Journal Article
MOLECULAR PHARMACOLOGY, ISSN 0026-895X, 09/2013, Volume 84, Issue 3, pp. 425 - 437
Recent interest in the M-1 muscarinic acetylcholine (ACh) receptor (mAChR) has led to the discovery of various selective agonists for the receptor. The novel... 
DRUG | SITE | ACTIVATION | SUBTYPE SELECTIVITY | PHARMACOLOGY | EXPLORATION | FUNCTIONAL SELECTIVITY | SCHIZOPHRENIA | PHARMACOLOGY & PHARMACY | XANOMELINE | BINDING
Journal Article
No results were found for your search.

Cannot display more than 1000 results, please narrow the terms of your search.